Tái phát bệnh bạch cầu cấp tính ở trẻ em sau khi cấy ghép tế bào gốc đồng loại cho thấy sự đa dạng cao, động lực clone, áp lực chọn lọc và những mục tiêu có thể điều trị

Blood Advances - Tập 3 - Trang 3143-3156 - 2019
Jessica I. Hoell1,2,3, Sebastian Ginzel1,2,4,5, Michaela Kuhlen6,2, Andreas Kloetgen1,2,7, Michael Gombert6,2, Ute Fischer1,2, Daniel Hein6,2, Salih Demir8,9, Martin Stanulla10, Martin Schrappe11, Udo zur Stadt12, Peter Bader13, Florian Babor1,2, Friedhelm Schuster6,2, Brigitte Strahm14, Julia Alten11, Anja Moericke11, Gabriele Escherich15, Arend von Stackelberg16, Ralf Thiele4
1Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany;
2German Consortium for Translational Cancer Research (DKTK), Partner site Essen/Düsseldorf, Heidelberg, Germany;
3Department of Pediatric Hematology and Oncology, Martin Luther University Halle-Wittenberg, Halle, Germany;
4Department of Computer Science, Bonn-Rhine-Sieg University of Applied Sciences, Sankt-Augustin, Germany;
5Fraunhofer Institut für Intelligente Analyse und Informationssysteme, Schloss Birlinghoven, St. Augustin, Germany;
6Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany
7Computational Biology of Infection Research, Helmholtz Center for Infection Research, Braunschweig, Germany;
8Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany
9International Graduate School of Molecular Medicine, Ulm University, Ulm, Germany.
10Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
11Department of Pediatrics, University Medical Center Schleswig-Holstein, Kiel Campus, Kiel, Germany;
12Center for Diagnostics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
13University Hospital for Children and Adolescents, Frankfurt am Main, Germany;
14Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany;
15Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
16Pediatric Hematology and Oncology, Charité University Hospital, Berlin, Germany;

Tóm tắt

Điểm chính Tái phát bệnh bạch cầu cấp tính ở trẻ em sau khi cấy ghép tế bào gốc đồng loại thể hiện những tổn thương di truyền đa dạng, động lực và cá nhân hóa rất cao. Chín trong số mười bệnh nhân cấy ghép tái phát ở trẻ em cho thấy các thay đổi di truyền mà liệu pháp nhắm mục tiêu mới có sẵn.

Từ khóa


Tài liệu tham khảo

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