Patterns of Benzodiazepine Abuse and Dependence

Wiley - Tập 81 Số 1 - Trang 87-94 - 1986
Usoa Busto1, Edward M. Sellers1, Claudio A. Naranjo1, Howard Cappell2, Martha Sanchez‐Craig2, Jan Simpkins1
1Clinical Pharmacology Program and Pharmacy Department, Clinical Institute, Addiction Research Foundation; Faculty of Pharmacy and Departments of Pharmacology and Medicine
2Behavioural Research Program, Clinical Institute, Addiction Research Foundation; Departments of Pharmacology, Psychology and Behavioural Sciences, University of Toronto, Toronto, Canada

Tóm tắt

SummaryPatterns of benzodiazepine abuse and dependence are not well known. Data on drug use and other demographic and clinical characteristics were collected in 176 patients consecutively referred to the Addiction Research Foundation Clinical Institute for assessment and treatment of benzodiazepine abuse and/or dependence. Objective confirmation of benzodiazepine use was obtained in 95% of subjects screened. Two groups of subjects emerged: patients who used only benzodiazepines (median daily dose: 15 mg of diazepam or equivalent) for long periods of time (56%) and those who used benzodiazepines (median daily dose: 40 mg of diazepam or equivalent) in the context of multiple drug abuse (44%). Benzodiazepines were the primary drug of abuse in 23 (32%) of the multiple drug abusers. Patients using only benzodiazepines were significantly older, took lower daily doses and their life‐time benzodiazepine exposure was lower. Diazepam was most frequently alleged in both groups, but relative preference for other benzodiazepines differed. The results have implications for recognition, assessment, management and treatment of benzodiazepine abuse and dependence.

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Wiley

Tập 81 Số 1

87-94

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