Patient-specific finite element analysis of ascending aorta aneurysms

American Journal of Physiology - Heart and Circulatory Physiology - Tập 308 Số 10 - Trang H1306-H1316 - 2015
Caitlin Martin1, Wei Sun1, John A. Elefteriades2
1Tissue Mechanics Laboratory, The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia; and
2Aortic Institute of Yale-New Haven Hospital, Yale University, New Haven, Connecticut.

Tóm tắt

Catastrophic ascending aorta aneurysm (AsAA) dissection and rupture can be prevented by elective surgical repair, but identifying individuals at risk remains a challenge. Typically the decision to operate is based primarily on the overall aneurysm size, which may not be a reliable indicator of risk. In this study, AsAA inflation and rupture was simulated in 27 patient-specific finite element models constructed from clinical CT imaging data and tissue mechanical testing data from matching patients. These patients included n = 8 with concomitant bicuspid aortic valve (BAV), n = 10 with bovine aortic arch (BAA), and n = 10 with neither BAV nor BAA. AsAA rupture risk was found to increase with elevated systolic wall stress and tissue stiffness. The aortic size index was sufficient for identifying the patients with the lowest risk of rupture, but unsuitable for delineating between patients at moderate and high risk. There was no correlation between BAV or BAA and AsAA rupture risk; however, the AsAA morphology was different among these patients. These results support the use of mechanical parameters such as vessel wall stress and tissue stiffness for AsAA presurgical evaluation.

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American Journal of Physiology - Heart and Circulatory Physiology

Tập 308 Số 10

H1306-H1316

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