Patient Online Self-Reporting of Toxicity Symptoms During Chemotherapy

American Society of Clinical Oncology (ASCO) - Tập 23 Số 15 - Trang 3552-3561 - 2005
Ethan Basch1, David Artz1, Dorothy Dulko1, Kevin S. Scher1, Paul Sabbatini1, Martee L. Hensley1, Nandita Mitra1, John Speakman1, Mary S. McCabe1, Deborah Schrag1
1From the Departments of Epidemiology and Biostatistics, Medicine, Nursing, Information Services, and the Office of the Physician-in-Chief, Memorial Sloan-Kettering Cancer Center, New York, NY

Tóm tắt

Purpose Tracking symptoms related to treatment toxicity is standard practice in routine care and during clinical trials. Currently, clinicians collect symptom information via complex and often inefficient mechanisms, but there is growing interest in collecting outcome information directly from patients. Patients and Methods The National Cancer Institute Common Terminology Criteria for Adverse Events schema for seven common symptoms was adapted into a Web-based patient-reporting system, accessible from desktop computers in outpatient clinics and from home computers. Eighty patients with gynecologic malignancies beginning standard chemotherapy regimens were enrolled between April and September 2004. During an 8-week observation period, participants were encouraged to log in and report symptoms at each follow-up visit, or alternatively, to access the system from home. Results All patients completed an initial log in. At each subsequent appointment, most enrollees (80% to 85%) reported symptoms using the online system, with a mean of three follow-up visits per patient during the observation period (range, one to six). Sixty of 80 patients (75%) logged in at least once from home. Use was significantly associated with prior Internet experience. Forty-two severe toxicities (grade 3 to 4) entered from home prompted seven clinician interventions. Most patients (96%) found the system useful and would recommend it to others. Conclusion Patients are capable of reporting symptoms experienced during chemotherapy using a Web-based interface. Assessment in the clinical trial setting and comparison of direct patient- versus clinician-based approaches for reporting symptoms and their severity are warranted.

Từ khóa


Tài liệu tham khảo

Fairclough DL: Design and Analysis of Quality of Life Studies in Clinical Trials . Boca Raton, FL, CRC Press, 2002

National Cancer Institute: Common Terminology Criteria for Adverse Events (CTCAE) version 3.0 , June 10, 2003 update. http://ctep.cancer.gov/forms/CTAEv3.pdf

10.1200/jco.2004.22.14_suppl.714

10.1001/jama.280.14.1264

10.1016/0090-4295(93)90524-E

10.1200/JCO.2001.19.7.2064

10.1200/JCO.2004.03.025

10.1016/S0022-5347(01)63222-1

Vogelzang NJ, Breitbart W, Cella D, et al: Patient, caregiver, and oncologist perceptions of cancer-related fatigue: Results of a tripart assessment survey—The Fatigue Coalition. Semin Hematol 34:4,1997-12, (suppl 2)

Gwede CK, Johnson DJ, Daniels SS, et al: Assessment of toxicity in cooperative oncology clinical trials: The long and short of it. J Oncol Manag 11:15,2002-21,

10.1046/j.1524-4733.2003.65309.x

10.1111/j.1472-8206.2004.00234.x

10.1191/0962280204sm357ra

10.1186/1477-7525-1-79

10.1200/JCO.1993.11.3.570

West Clinic: The patient care monitor system. http://www.westclinic.com/monitors_content.html#

10.1056/NEJMoa040720

10.1200/JCO.2003.07.128

10.1053/S0093-7754(04)00394-X

10.1002/cncr.11578

10.3816/CGC.2004.n.011

10.1200/JCO.2003.11.044

10.1046/j.1523-5394.2002.103006.x

Le PP, Kohane IS, Weeks JC. Using a pen-based computer to collect health-related quality of life and utilities information. Proc 19th Annu Symp Comput Appl Med Care :839,1995-843

10.1200/JCO.1999.17.3.998

10.1097/00000421-198212000-00014

10.3109/07853890109002087

10.2165/00019053-199813040-00005

10.1136/bmj.320.7248.1517

10.1200/JCO.1999.17.9.2882

10.1200/JCO.2002.03.039

10.1093/jnci/92.12.1011

Bjorner JB, Kosinski M, Ware JE Jr: The feasibility of applying item response theory to measures of migraine impact: A re-analysis of three clinical studies. Qual Life Res 12:887,2003-902,

10.1023/A:1026115230284

Thông tin
Thông tin xuất bản

American Society of Clinical Oncology (ASCO)

Tập 23 Số 15

3552-3561

Thông tin tác giả