Pathologic and Immunohistochemical Findings in Naturally Occurring West Nile Virus Infection in Horses

Veterinary Pathology - Tập 38 Số 4 - Trang 414-431 - 2001
Carlo Cantile1, Fábio Del Piero2, Giovanni Di Guardo3, M. Arispici1
1Dipartimento di Patologia Animale, Facoltà di Medicina Veterinaria, Università degli Studi di Pisa, Pisa, Italy
2Department of Pathobiology, School of Veterinary Medicine, New Bolton Center, University of Pennsylvania, Kennett Square, PA
3Istituto Zooprofilattico Sperimentale delle Regioni Lazio e Toscana, Rome, Italy

Tóm tắt

The pathologic and peroxidase immunohistochemical features of West Nile flavivirus (WNV) infection were compared in four horses from the northeastern United States and six horses from central Italy. In all 10 animals, there were mild to severe polioencephalomyelitis with small T lymphocyte and lesser macrophage perivascular infiltrate, multifocal glial nodules, neutrophils, and occasional neuronophagia. Perivascular hemorrhages, also noted macroscopically in two animals, were observed in 50% of the horses. In the four American horses, lesions extended from the basal nuclei through the brain stem and to the sacral spinal cord and were more severe than the lesions observed in the six Italian horses, which had moderate to severe lesions mainly in the thoracolumbar spinal cord and mild rhombencephalic lesions. WNV antigen was scant and was identified within the cytoplasm of a few neurons, fibers, glial cells, and macrophages. WNV infection in horses is characterized by lesions with little associated antigen when compared with WNV infection in birds and some fatal human infections and with other important viral encephalitides of horses, such as alphavirus infections and rabies.

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Thông tin xuất bản

Veterinary Pathology

Tập 38 Số 4

414-431

Thông tin tác giả