Patch testing with fragrances: results of a multicenter study of the European Environmental and Contact Dermatitis Research Group with 48 frequently used constituents of perfumes

Contact Dermatitis - Tập 33 Số 5 - Trang 333-342 - 1995
Wolfgang Uter1, Beate Pilz1,2, K. E. Andersen3, D. Burrows4, José G. Camarasa5, A. Dooms‐Goossens6, G. Ducombs7, Thomas Fuchs2,8, M. Hannusksela9, Jean‐Marie Lachapelle10, A. Lahti9, Howard I. Maibach11, Torkil Menné12, R. J. G. Rycroft13, S. Shaw14,2, Jan E. Wahlberg15, Ian R. White13, J. D. Wilkinson14
1Department of Dermatology, Städtische Kliniken Dortmund
2Not a member of the EECDRG.
3University of Witten/Herdecke, University of Odense, Odense
4Royal Victoria Hospital, Belfast
5Hospital de N.S. del Mar, Barcelona
6Department of Dermatology, University Hospital St. Rafaël, Leuven
7Hôpital Saint André, Université de Bordeaux
8Universität Hautklinik, Göttingen
9University of Oulu, Oulu
10University of Louvain, Brussels
11University of California San Francisco
12Gentofte Hospital, University of Copenhagen,
13St. John's Dermatology Centre, St. Thomas's Hospital, London
14Amersham General Hospital, Amersham
15Karolinska Sjukhuset, University of Stockholm

Tóm tắt

The objective of this study was to determine the frequency of reactivity to a series of commonly fragrances in dermatological patients. A total of 48 fragrances (FF) were chosen, based on the publication of Fenn in 1989 in which the lop 25 constituents of 3 types (1. perfumes, 2. household products, 3. soaps) of 400 commercial products on the US market had been determined. In a pilot study on a total of 1069 patients in 11 centres, the appropriate test concentration and vehicle were examined. For most fragrances, 1% and 5% were chosen, and petrolatum proved to be the best vehicle in comparison to isopropyl myristate and diethyl phthalate. In the main study, a set of 5 to 10 fragrances at 2 concentrations was patch tested in each centre on a minimum of 100 consecutive patients seen in the patch test clinic. These patients were also patch tested to a standard series with the 8% fragrance mix (FM) and its 8 constituents. In patients with a positive reaction to any of the 48 FF, a careful history with regard to past or present reactions to perfumed products was taken. A total of 1323 patients were tested in 11 centres. The 8% FM was positive in 89 patients (8.3% of 1072 patients). Allergic reactions to the constituents were most frequent to oak moss (24), isoeugenol (20), eugenol (13), cinnamic aldehyde (10) and geraniol (8). Reactions read as allergic on day 3/4 were observed only 10 × to 7 materials of the new series (Iso L: Super® (2), Lyral® (3), Cyclacet® (1), DMBCA (1), Vertofix® (1), citronellol (1) and amyl salicylate (1)). The remaining 41 fragrances were negative. 28 irritant or doubtful reactions on day 3/4 were observed to a total of 19 FF materials (more than 1 reaction: 5% citronellol (2), 1%amyl salicylate (2), 1%isononyl acetate (3), 0.1% musk xylol (2). 1%citral (2), and 1% ionone beta (2)). Clinical relevance of positive reactions to any of the FF series was not proved in a single case. This included the 4 reactions in patients who were negative to the 8% FM. In conclusion, the top 25 fragrances commonly found in various products caused few reactions in dermatological patients and these few appeared to be clinically irrelevant, with the possible exeption of Lyral®. However, this data should be interpreted in the light of the relatively small number of patients tested (only 100 in most centres).

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Tài liệu tham khảo

10.1016/S0190-9622(80)80193-9

DeGrootA C.Adverse reactions to cosmetics.Thesis University of Groningen 1988.

Nielsen N H, 1992, Allergic contact sensitization in an unselected Danish population. The Glostrup Allergy Study. Denmark, Acta Dermato-venereologica, 72, 456, 10.2340/0001555572456460

Nakayama H, 1974, Allergic Controlled Systems (ACS)

10.1111/j.1365-4362.1984.tb04055.x

Larsen W G, 1977, Perfume dematitis. A study of 20 patients, Arch Dermatol, 113, 623, 10.1001/archderm.1977.01640050083012

Schnuch A, 1993, Epikutantestung mit der Standarddreihe Erste Ergebnise des Projektes “Informationsverbund Dermatologischer Kliniken” (IVDK), Dermatosen, 41, 60

Froch P J, 1995, Fortschritte der Dermatologie und venerologie

10.1111/j.1600-0536.1995.tb00834.x

Dooms‐GoossensA. Personal communication.

10.1111/j.1600-0536.1992.tb00894.x

10.1097/01634989-199203000-00006

Wilkinson J D, 1989, Current topics in contact dermatitis, 385

Frosch P J, 1995, Testing with the fragrance mix is the addition of sorbitan sesquioleate to the constituents useful, Contact Dermatitis, 14, 1

Fenn R S, 1989, Aroma chemical usage trends in modern perfurmery, Perfumers & Flavorist, 14, 1

Wahlberg J, 1992, Textbook of contact dermatitis: Heidelberg, 241

Weyland J W, 1994, Unwanted effects of cosmetic and drug used in dermatology, 579

10.1007/BF00125560

Bauer K, 1988, Ullmann's Encyclopedia of Industrial Chemistry, 141

OpdykeD L J.Amyl salicylate.Monographs on fragrance raw materials. Food and Cosmetic Toxicology.1973:235.

OpdykeD L J.Citronellol.Monographs on fragrance raw materials. Food and Cosmetic Toxicology 1973:235.

10.1038/jid.1947.46

OpdykeD L J.Cyclacet.RIFM Monographs. Food and Cosmetic Toxicology 1973:714.

OpdykeD L J.DMBCA.RIFM MonographsFood and Cosmetic Toxicology.1973:325.

OpdykeD L J.VertofixRIFM MonographsFood and Cosmetic Toxicology.1973:639.

Kligman A M, 1966, The identification of contact allergens by human assay (III). The maximization test, A procedure for screening and rating contact sensitizers, J Invest Derm, 47, 393, 10.1038/jid.1966.160

10.1111/j.1600-0536.1975.tb05389.x

OpdykeD L J.α‐Irone.Monographs on fragrance raw materials. Food and Cosmetic Toxicology.1973:446.

OpdykeD L J.Lavandin Oil.Monographs on fragrance raw materials. Food and Cosmetic Toxicology 1973:484.

OpdykeD L J.Orange oil.Monographs on fragrance raw materials. Food and Cosmetic Toxicology.1973:607.

OpdykeD L J.Methyl ionone.Monographs on fragrance raw materials. Food and Cosmetic Toxicology.1979:359.

OpdykeD L J.Methyl octane carbonate.Monographs on fragrance raw materials. Food and Cosmetic Toxicology.1973:444.

OpdykeD L J.Methyl octane carbonate.Monographs on fragrance raw materials. Food and Cosmetic Toxicology 1973:565.

Greif N, 1967, Cutaneous, safety of fragrance materials as measured by the maximization test, Am perfumer Cosmet, 82, 54

Woeber K, 1969, Zur Frage der Sensibilisierung durch ätherische, Öle, Berufsdermatosen, 17, 320

Groot A C, 1988, The allergens in cosmetics, Arch Dermatol, 124, 1525, 10.1001/archderm.1988.01670100027007

10.1111/j.1600-0536.1979.tb05528.x

Hausen B, 1994, Lexikon der Kontaktallergene ecomed, Landsbeg am Lech, 1

Marzulli F N, 1980, Contact allergy: Predictive testing of fragrance ingredients in humans by Draize and maximization methods, J Environ Path Toxicol, 3, 235

OpdykeD L J.Eugenol.Monographs on fragrance raw materials. Food and Cosmetic Toxicology 1973:376.

10.1016/0278-6915(88)90090-7

OpdykeD L J.Hexyl cinnamic aldehyde.Monographs on fragrance raw materials. Food and Cosmetic Toxicology 1973:429.

10.1111/j.1600-0536.1988.tb04510.x

IFRA (International Fragrance Association), 1983, Code de bons usages

10.1016/0278-6915(93)90181-W

Sugai T, 1994, Group Study IV‐farnesol and lily aldehyde, Environ Dermatol, 1, 213

Sugai T, 1994, Historical data of the JSCD. Group study III: fragrance materials, Environ Dermatol, 1, 209

Tokura H, 1994, A case of contact dermatitis due to smoke of increase stick, Environ Dermatol, 1, 168

Rastogi S C, 1994, 16th International Symposium on Capillary chromatography, 955

Ford R A, 1991, Perfumes. Art Science & Technology, 441

FordR A.Lyral.Monographs on fragrance raw materials. Food and Chemical Toxicology 1992:49–51.

Benke G M, 1984, Safety evaluation of perfumed shampoos: dose/response relationships for product use testing by presensitized subjects, Journal of Toxicology, 3, 65

Dinardo J C, 1985, A quantitative in vitro assay for the evalution of phototoxic potential of topically applied materials. (II) Modification and assessment of low level activity, Journal of the Society of Cosmetic Chemists, 36, 425

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Contact Dermatitis

Tập 33 Số 5

333-342

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