Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt–β-catenin–mediated intestinal tumor growth and regeneration

Science Signaling - Tập 7 Số 345 - 2014
Toby J. Phesse1,2,3, Michael Büchert1,2,3, Emma Stuart1,2,3, Dustin J. Flanagan4,5,6, Maree C. Faux1,2,3, Shoukat Afshar‐Sterle1,2,3, Francesca Walker1,2,3, Huihua Zhang1,2,3, Cameron J. Nowell1,2,3, Robert N. Jorissen1,2,3, Chin Wee Tan1,2,3, Yumiko Hirokawa1,2,3, Moritz F. Eissmann1,2,3, Christopher G. Love1,2,3, Jordane Malaterre7,8, Helen Pearson7,8, David G. Kirsch9, Paolo Provero10, Valeria Poli10, Robert G. Ramsay7,8, Oliver M. Sieber1,2,3, Antony W. Burgess1,2,3, Dennis Huszar11, Elizabeth Vincan4,5,6, Matthias Ernst1,2,3
1Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3052, Australia.
2Ludwig Institute for Cancer Research, Melbourne, Victoria 3052, Australia.
3Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia
4Department of Anatomy and Cell Biology, University of Melbourne, Melbourne, Victoria, 3052, Australia
5School of Biomedical Sciences, Curtin University, Perth, Western Australia 6845, Australia.
6Victorian Infectious Diseases Reference Laboratories, North Melbourne, Victoria 3051, Australia.
7Peter MacCallum Cancer Centre, Melbourne, Victoria 3002, Australia
8Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Melbourne, Victoria 3052, Australia.
9Departments of Radiation Oncology, Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.
10Department of Genetics, Biology and Biochemistry, University of Turin, 10126 Torino, Italy.
11Oncology iMED, AstraZeneca, Waltham, MA 02451, USA.

Tóm tắt

Partial suppression of the inflammatory gp130-Jak-Stat pathway inhibits intestinal tumor growth.

Từ khóa


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Tập 7 Số 345

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