Nghịch lý của trimethylamine-N-oxide, tác động của tình trạng suy dinh dưỡng đối với các chất chuyển hóa có nguồn gốc từ vi sinh vật và bệnh nhân nhiễm khuẩn
Tóm tắt
Trimethylamine
Tổng cộng 95 bệnh nhân nhiễm khuẩn, được thở máy đã được đưa vào nghiên cứu. Mẫu máu được lấy trong vòng 24 giờ sau khi nhập ICU, và nồng độ TMAO trong huyết tương được xác định. Bệnh nhân nhiễm khuẩn được nhóm thành các tertile dựa trên nồng độ TMAO. Kết quả chính là tử vong trong bệnh viện, và được phân loại thành tử vong do CV và không do CV. Ngoài ra, chúng tôi cũng so sánh nồng độ TMAO của bệnh nhân nhiễm khuẩn với 129 bệnh nhân không nhiễm khuẩn nhập viện để thực hiện chụp động mạch vành có kế hoạch (CAG).
Các bệnh nhân nhiễm khuẩn có nồng độ TMAO trong huyết tương thấp hơn đáng kể so với những người nhập viện để chụp CAG (1.0 so với 3.0 μmol/L,
Nồng độ TMAO trong huyết tương có mối liên hệ nghịch với tử vong không do CV ở những bệnh nhân nhiễm khuẩn cực kỳ nặng, điều này có thể được mô tả là nghịch lý TMAO. Đối với bệnh nhân nhiễm khuẩn, tác động của tình trạng suy dinh dưỡng phản ánh qua nồng độ TMAO trong tuần hoàn lớn hơn tính chất pro-inflammatory của nó.
Từ khóa
Tài liệu tham khảo
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