Pandemic Clones of CTX-M-15 Producing Klebsiella pneumoniae ST15, ST147, and ST307 in Companion Parrots

Microorganisms - Tập 10 Số 7 - Trang 1412
Yamê Miniero Davies1, Marcos Paulo Vieira Cunha1, Milena Dropa2, Nilton Lincopán3, Vasco T. M. Gomes1, Luisa Zanoli Moreno1, Maria Inês Zanoli Sato4, Andréa Micke Moreno1, Terezinha Knöbl1
1School of Veterinary Medicine and Animal Science, University of São Paulo, Av. Prof. Dr. Orlando Marques de Paiva, 87, Cidade Universitária, São Paulo 05508-270, SP, Brazil
2Environmental Health Department, School of Public Health, University of São Paulo, Avenida Dr. Arnaldo, 715, Cerqueira César, São Paulo 05508-270, SP, Brazil
3Department of Microbiology, Institute of Biomedical Sciences, Universidade de São Paulo, Av. Prof. Lineu Prestes, 2415-Butantã, São Paulo 05508-000, SP, Brazil
4São Paulo State Environment Agency (CETESB), Av. Prof. Frederico Hermann Jr. 345. Pinheiros, São Paulo 05459-010, SP, Brazil

Tóm tắt

Psittacine birds are commonly kept as companion birds and the maintenance of these birds in captivity may represent a zoonotic risk and contribute to the propagation of multidrug-resistant and β-lactamase extended-spectrum (ESBLs)-producing pathogens. This study aimed to identify and characterize strains of the Klebsiella pneumoniae complex isolated from diseased psittacine birds, determining virulence and resistance profiles. K. pneumoniae strains were isolated from 16 birds (16/46). All strains carried more than three virulence genes, with a high frequency of fimH and kpn (93.75%), uge (87.52%), and irp-2 (81.25%) genes. The antimicrobial susceptibility revealed that 3/16 strains were ESBL producers. Genomic analysis revealed that CTX-M-15-positive strains belonged to sequence types (STs) ST15, ST147, and ST307, characterized as international clones associated with outbreaks of healthcare-associated infections (HAIs) worldwide.

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