Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

Nature Cell Biology - Tập 17 Số 6 - Trang 816-826 - 2015
Bruno Costa‐Silva1, Nicole M. Aiello2, Allyson J. Ocean3, Swarnima Singh1, Haiying Zhang1, Basant Kumar Thakur1, Annette Becker1, Ayuko Hoshino1, Milica Tešić Mark4, Henrik Molina4, Jenny Xiang5, Tuo Zhang5, Till M. Theilen1, Guillermo García‐Santos1, Caitlin Williams1, Yonathan Ararso1, Yujie Huang1, Gonçalo Rodrigues1, Tang‐Long Shen6, Knut Jørgen Labori7, Inger Marie Bowitz Lothe8, Elin H. Kure9, Jonathan M. Hernandez10, Alexandre Doussot10, Saya H. Ebbesen1, Paul M. Grandgenett11, Michael A. Hollingsworth11, Maneesh Jain12, Kavita Mallya12, Surinder K. Batra12, William R. Jarnagin10, Robert E. Schwartz13, Irina Matei1, Héctor Peinado14, Ben Z. Stanger2, Jacqueline Bromberg15, David Lyden16
1Departments of Pediatrics, Children’s Cancer and Blood Foundation Laboratories, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medical College, New York, New York 10021, USA
2Gastroenterology Division, Department of Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
3Department of Medicine, Division of Hematology and Medical Oncology, New York Presbyterian Hospital, Weill Cornell Medical College, New York, New York 10021, USA
4Proteomics Resource Center, The Rockefeller University, New York, New York 10065, USA
5Genomics Resources Core Facility, Weill Cornell Medical College, New York, New York 10021, USA
6Department of Plant Pathology and Microbiology, National Taiwan University, Taipei 10617, Taiwan
7Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Nydalen, Oslo 0424, Norway
8Department of Pathology, Oslo University Hospital, Nydalen, Oslo 0424, Norway
9Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Nydalen, Oslo 0424, Norway
10Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
11Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
12Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
13Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medical College, New York, New York 10021, USA
14Department of Molecular Oncology, Microenvironment and Metastasis Laboratory, Spanish National Cancer Research Center (CNIO), Madrid 28029, Spain
15Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, New York 10065, USA
16Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA

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