Paediatric supratentorial tumours do not cause microstructural alterations in contralateral white matter: a preliminary study

Barış Genç1, Semra Delibalta2, Kerim Aslan3, Meltem Necibe Ceyhan Bilgici4
1Department of Radiology, Samsun Education and Research Hospital, Samsun, Turkey
2Department of Radiology, Amasya Sabuncuoğlu Şerefeddin Education and Research Hospital, Amasya, Turkey
3Department of Radiology, Ondokuz Mayis University School of Medicine, Samsun, Turkey
4Department of Pediatric Radiology, Ondokuz Mayıs University School of Medicine, Samsun, Turkey

Tóm tắt

Intracranial tumours in children can exhibit different characteristics compared to those in adults. Understanding the microstructural changes in the contralateral normal-appearing white matter (NAWM) in children with primary intracranial masses is essential for optimizing treatment strategies. This study aimed to investigate the apparent diffusion coefficient (ADC) changes in contralateral NAWM using fully automated methods and deep learning algorithms. We included 22 paediatric patients with primary supratentorial intracranial masses (23% high-grade) in the study. ADC values of the contralateral NAWM in the patient group were compared to those of a control group. Deep learning algorithms were utilized to analyse diffusion changes in NAWM. The mean ADC values of contralateral NAWM in the patient group were 0.80 ± 0.03 × 10−3 mm2/s, while the control group had a mean ADC value of 0.81 ± 0.03 × 10−3 mm2/s. There was no statistically significant difference between the groups (p = 0.39). Our findings indicate that there are no significant diffusion changes in the contralateral white matter of children with supratentorial intracranial masses. Primary supratentorial intracranial masses in children do not cause microstructural changes in contralateral normal-appearing white matter. This could be attributed to the less infiltrative nature and different biochemical profile of these tumour groups in the paediatric population. Further studies using advanced imaging techniques could provide additional insights into the distinct characteristics of paediatric intracranial tumours and improve patient management.

Tài liệu tham khảo

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