PKCβII inhibition attenuates myocardial infarction induced heart failure and is associated with a reduction of fibrosis and pro-inflammatory responses
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Churchill, 2008, PKC isozymes in chronic cardiac disease: possible therapeutic targets, Annu Rev Pharmacol Toxicol, 48, 569, 10.1146/annurev.pharmtox.48.121806.154902
Palaniyandi, 2009, Protein kinase C in heart failure: a therapeutic target, Cardiovasc Res, 82, 229, 10.1093/cvr/cvp001
Hambleton, 2006, Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure, Circulation, 114, 574, 10.1161/CIRCULATIONAHA.105.592550
Inagaki, 2003, Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo, Circulation, 108, 2304, 10.1161/01.CIR.0000101682.24138.36
Inagaki, 2002, Tissue angiotensin II during progression or ventricular hypertrophy to heart failure in hypertensive rats; differential effects on PKC epsilon and PKC beta, J Mol Cell Cardiol, 34, 1377, 10.1006/jmcc.2002.2089
Inagaki, 2008, Pharmacological inhibition of epsilon-protein kinase C attenuates cardiac fibrosis and dysfunction in hypertension-induced heart failure, Hypertension, 51, 1565, 10.1161/HYPERTENSIONAHA.107.109637
Braun, 2003, Opposing effects of delta- and zeta-protein kinase C isozymes on cardiac fibroblast proliferation: use of isozyme-selective inhibitors, J Mol Cell Cardiol, 35, 895, 10.1016/S0022-2828(03)00142-1
Bowling, 1999, Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart, Circulation, 99, 384, 10.1161/01.CIR.99.3.384
Sabri, 2003, Protein kinase C isoform-selective signals that lead to cardiac hypertrophy and the progression of heart failure, Mol Cell Biochem, 251, 97, 10.1023/A:1025490017780
Simonis, 2007, Protein kinase C in the human heart: differential regulation of the isoforms in aortic stenosis or dilated cardiomyopathy, Mol Cell Biochem, 305, 103, 10.1007/s11010-007-9533-3
Wakasaki, 1997, Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy, Proc Natl Acad Sci U S A, 94, 9320, 10.1073/pnas.94.17.9320
Piacentini, 2000, Endothelin-1 stimulates cardiac fibroblast proliferation through activation of protein kinase C, J Mol Cell Cardiol, 32, 565, 10.1006/jmcc.2000.1109
Baines, 2002, Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection, Circ Res, 90, 390, 10.1161/01.RES.0000012702.90501.8D
Sentex, 2006, Expression of protein kinase C isoforms in cardiac hypertrophy and heart failure due to volume overload, Can J Physiol Pharmacol, 84, 227, 10.1139/y05-120
Bates, 2008, Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction, Circulation, 117, 886, 10.1161/CIRCULATIONAHA.107.759167
Takano, 2003, Implication of cardiac remodeling in heart failure: mechanisms and therapeutic strategies, Intern Med, 42, 465, 10.2169/internalmedicine.42.465
Cohn, 1995, Structural basis for heart failure. Ventricular remodeling and its pharmacological inhibition, Circulation, 91, 2504, 10.1161/01.CIR.91.10.2504
Pfeffer, 1979, Myocardial infarct size and ventricular function in rats, Circ Res, 44, 503, 10.1161/01.RES.44.4.503
Oliveira, 2009, Cardiac anti-remodelling effect of aerobic training is associated with a reduction in the calcineurin/NFAT signalling pathway in heart failure mice, J Physiol, 587, 3899, 10.1113/jphysiol.2009.173948
Pereira, 2009, Exercise training reduces cardiac angiotensin II levels and prevents cardiac dysfunction in a genetic model of sympathetic hyperactivity-induced heart failure in mice, Eur J Appl Physiol, 105, 843, 10.1007/s00421-008-0967-4
Palaniyandi, 2004, Inhibition of mast cells by interleukin-10 gene transfer contributes to protection against acute myocarditis in rats, Eur J Immunol, 34, 3508, 10.1002/eji.200425147
Stebbins, 2001, Binding specificity for RACK1 resides in the V5 region of beta II protein kinase C, J Biol Chem, 276, 29644, 10.1074/jbc.M101044200
Moustakas, 2001, Smad regulation in TGF-beta signal transduction, J Cell Sci, 114, 4359, 10.1242/jcs.114.24.4359
Chen, 2008, Cytokines and acute heart failure, Crit Care Med, 36, S9, 10.1097/01.CCM.0000297160.48694.90
Niebauer, 2000, Inflammatory mediators in heart failure, Int J Cardiol, 72, 209, 10.1016/S0167-5273(99)00190-4
Palaniyandi Selvaraj, 2005, Involvement of mast cells in the development of fibrosis in rats with postmyocarditis dilated cardiomyopathy, Biol Pharm Bull, 28, 2128, 10.1248/bpb.28.2128
Bowman, 1997, Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates, J Clin Invest, 100, 2189, 10.1172/JCI119755
Roman, 2001, PKC-beta is not necessary for cardiac hypertrophy, Am J Physiol Heart Circ Physiol, 280, H2264, 10.1152/ajpheart.2001.280.5.H2264
Boyle, 2005, Inhibition of protein kinase C reduces left ventricular fibrosis and dysfunction following myocardial infarction, J Mol Cell Cardiol, 39, 213, 10.1016/j.yjmcc.2005.03.008
Nikodemova, 2007, Minocycline down-regulates MHC II expression in microglia and macrophages through inhibition of IRF-1 and protein kinase C (PKC)alpha/betaII, J Biol Chem, 282, 15208, 10.1074/jbc.M611907200
Devaraj, 2005, Hyperglycemia induces monocytic release of interleukin-6 via induction of protein kinase c-{alpha} and -{beta}, Diabetes, 54, 85, 10.2337/diabetes.54.1.85
Lewin, 1996, Aggregation of the Fc epsilon RI in mast cells induces the synthesis of Fos-interacting protein and increases its DNA binding-activity: the dependence on protein kinase C-beta, J Biol Chem, 271, 1514, 10.1074/jbc.271.3.1514
Kawakami, 2004, Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion, J Biol Chem, 279, 47720, 10.1074/jbc.M408797200
Nechushtan, 2000, Inhibition of degranulation and interleukin-6 production in mast cells derived from mice deficient in protein kinase Cbeta, Blood, 95, 1752, 10.1182/blood.V95.5.1752.005k18_1752_1757
Ludowyke, 2006, Phosphorylation of nonmuscle myosin heavy chain IIA on Ser1917 is mediated by protein kinase C beta II and coincides with the onset of stimulated degranulation of RBL-2H3 mast cells, J Immunol, 177, 1492, 10.4049/jimmunol.177.3.1492