PI3K/PTEN/Akt and TSC/mTOR signaling pathways, ovarian dysfunction, and infertility: an update

Journal of Molecular Endocrinology - Tập 53 Số 3 - Trang R103-R118 - 2014
Annu Makker1, Madhu Mati Goel1, Abbas Ali Mahdi2
1Post-Graduate Department of PathologyDepartment of BiochemistryKing George's Medical University, Lucknow 226003, Uttar Pradesh, India.
21Post‐Graduate Department of Pathology2Department of BiochemistryKing George's Medical University, Lucknow 226003, Uttar Pradesh, India

Tóm tắt

Abnormalities in ovarian function, including defective oogenesis and folliculogenesis, represent a key female reproductive deficiency. Accumulating evidence in the literature has shown that the PI3K/PTEN/Akt and TSC/mTOR signaling pathways are critical regulators of ovarian function including quiescence, activation, and survival of primordial follicles, granulosa cell proliferation and differentiation, and meiotic maturation of oocytes. Dysregulation of these signaling pathways may contribute to infertility caused by impaired follicular development, intrafollicular oocyte development, and ovulation. This article reviews the current state of knowledge of the functional role of the PI3K/PTEN/Akt and TSC/mTOR pathways during mammalian oogenesis and folliculogenesis and their association with female infertility.

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Tài liệu tham khảo

2009, Molecular Human Reproduction, 15, 765, 10.1093/molehr/gap092

2010, Human Molecular Genetics, 19, 397, 10.1093/hmg/ddp483

Adhikari, 2012, 7, e39034, 10.1371/journal.pone.0039034

2013, 8, e53810, 10.1371/journal.pone.0053810

2004, Journal of Biological Chemistry, 279, 19431, 10.1074/jbc.M401235200

Albertini, 1994, Microscopy research and technique, 27, 125, 10.1002/jemt.1070270206

Allan, 2006, Journal of Endocrinology, 188, 549, 10.1677/joe.1.06614

2014, Human Reproduction, 29, 97, 10.1093/humrep/det388

2014, 9, e96210, 10.1371/journal.pone.0096210

Bao, 1998, Journal of Animal Science, 76, 1903, 10.2527/1998.7671903x

2012, JOURNAL OF OVARIAN RESEARCH, 5, 32, 10.1186/1757-2215-5-32

2013, BMC genomics [electronic resource], 14, 904, 10.1186/1471-2164-14-904

2010, Biology of Reproduction, 82, 246, 10.1095/biolreprod.109.077925

Cahill, 2002, BMJ, 325, 28, 10.1136/bmj.325.7354.28

Cecconi, 2010, Reproductive biomedicine online, 20, 35, 10.1016/j.rbmo.2009.10.011

2007, Endocrinology, 148, 3580, 10.1210/en.2007-0088

2009, Journal of Endocrinology, 202, 407, 10.1677/JOE-09-0109

Choi, 2010, Fertility and sterility, 93, 2532, 10.1016/j.fertnstert.2009.11.021

Choi, 2011, Fertility and sterility, 95, 1482, 10.1016/j.fertnstert.2010.06.006

2013, Reproduction, 147, 73, 10.1530/REP-13-0386

2008, Journal of Cell Science, 121, 3890, 10.1242/jcs.036400

Fair, 1997, Molecular reproduction and development, 46, 208, 10.1002/(SICI)1098-2795(199702)46:2<208::AID-MRD11>3.0.CO;2-X

Fair, 1997, Anatomy and embryology, 195, 327, 10.1007/s004290050052

2009, JOURNAL OF OVARIAN RESEARCH, 2, 17, 10.1186/1757-2215-2-17

2008, Molecular Endocrinology, 22, 2128, 10.1210/me.2008-0095

Farini, 2007, Developmental biology, 306, 572, 10.1016/j.ydbio.2007.03.031

Fassnacht, 2006, Current medicinal chemistry, 13, 1397, 10.2174/092986706776872943

Flanagan, 1991, Cell, 64, 1025, 10.1016/0092-8674(91)90326-T

2014, Biology of Reproduction, 90, 86, 10.1095/biolreprod.113.115089

2011, Reproduction, 141, 759, 10.1530/REP-10-0489

Goto, 2007, Journal of assisted reproduction and genetics, 24, 541, 10.1007/s10815-007-9156-3

2009, Reproduction, 137, 835, 10.1530/REP-08-0315

Greenfeld, 2007, Reproduction, 133, 865, 10.1530/REP-06-0270

Greenseid, 2011, Reproductive Sciences, 18, 892, 10.1177/1933719111398502

Gu, 2011, 6, e25984, 10.1371/journal.pone.0025984

Han, 2006, The EMBO Journal, 25, 5716, 10.1038/sj.emboj.7601431

2014, BMC genomics [electronic resource], 15, 24, 10.1186/1471-2164-15-24

2010, Molecular Human Reproduction, 16, 617, 10.1093/molehr/gaq068

Hoshino, 2008, Developmental biology, 314, 215, 10.1016/j.ydbio.2007.12.005

Hoshino, 2004, Molecular reproduction and development, 69, 77, 10.1002/mrd.20150

2013, 8, e540552

Huansheng, 2011, Biochemical and biophysical research communications, 410, 659, 10.1016/j.bbrc.2011.06.050

2012, PNAS, 109, E2979, 10.1073/pnas.1205661109

Iguchi, 1986, Teratology, 34, 29, 10.1002/tera.1420340105

Irusta, 2010, Molecular and cellular endocrinology, 325, 93, 10.1016/j.mce.2010.04.018

Jagarlamudi, 2009, 4, e6186, 10.1371/journal.pone.0006186

Jagarlamudi, 2010, Molecular and cellular endocrinology, 315, 1, 10.1016/j.mce.2009.07.016

2006, Biology of Reproduction, 74, 161, 10.1095/biolreprod.105.045724

2014, CELL DEATH DISEASE, 5, 1154e, 10.1038/cddis.2014.126

John, 2007, Reproduction, 133, 855, 10.1530/REP-06-0051

John, 2008, Developmental biology, 321, 197, 10.1016/j.ydbio.2008.06.017

John, 2009, Developmental biology, 331, 292, 10.1016/j.ydbio.2009.05.546

Jumayev, 2012, Nagoya journal of medical science, 74, 273

Kalous, 2006, Biology of the cell / under the auspices of the European Cell Biology Organization, 98, 111, 10.1042/BC20050020

2009, Reproduction, 138, 645, 10.1530/REP-08-0461

2013, PNAS, 110, 17474, 10.1073/pnas.1312830110

2008, Development, 135, 869, 10.1242/dev.013474

Klinge, 2001, Nucleic Acids Research, 29, 2905, 10.1093/nar/29.14.2905

2013, Molecular reproduction and development, 80, 334, 10.1002/mrd.22166

Laplante, 2012, Cell, 149, 274, 10.1016/j.cell.2012.03.017

La Sala, 2010, Experimental cell research, 316, 1716, 10.1016/j.yexcr.2010.03.024

Lee, 2012, Molecular reproduction and development, 79, 356, 10.1002/mrd.22035

2013, Development, 140, 2075, 10.1242/dev.093864

2010, PNAS, 107, 10280, 10.1073/pnas.1001198107

Liu, 2007, Development, 134, 199, 10.1242/dev.02667

2013, Molecular Endocrinology, 27, 238, 10.1210/me.2012-1296

2012, Reproduction, 144, 595, 10.1530/REP-12-0225

2010, Reproduction, 139, 139, 10.1530/REP-09-0050

Manning, 2007, Cell, 129, 1261, 10.1016/j.cell.2007.06.009

2012, Developmental biology, 375, 140

2012, Molecular Human Reproduction, 18, 96, 10.1093/molehr/gar083

2012, PLOS MEDICINE, 9, 1001356e, 10.1371/journal.pmed.1001356

2014, Molecular reproduction and development, 81, 363, 10.1002/mrd.22305

McCoshen, 1975, Experientia, 31, 589, 10.1007/BF01932475

McLaughlin, 2011, Fertility and sterility, 96, 1154, 10.1016/j.fertnstert.2011.08.040

2014, Molecular Human Reproduction, 20, 736, 10.1093/molehr/gau037

2007, SOCIETY OF REPRODUCTION AND FERTILITY SUPPLEMENT, 64, 55

Mork, 2012, Mechanisms of development, 128, 591, 10.1016/j.mod.2011.12.005

2012, Molecular Endocrinology, 26, 1732, 10.1210/me.2012-1106

2013, Molecular and cellular endocrinology, 366, 81, 10.1016/j.mce.2012.12.004

2013, NATURE COMMUNICATIONS, 4, 1843, 10.1038/ncomms2861

2007, PNAS, 104, 187, 10.1073/pnas.0609923104

PETERS, 1975, Reproduction, 45, 559, 10.1530/jrf.0.0450559

2013, Veterin&#x00A0;&#x00A0;rn&#x00A0;&#x00A0; medic&#x00A0;&#x00A0;na, 10, 505

Pisarska, 2009, Fertility and sterility, 91, 1392, 10.1016/j.fertnstert.2008.04.054

Rao, 2011, 6, e20754, 10.1371/journal.pone.0020754

Reddy, 2005, Developmental biology, 281, 160, 10.1016/j.ydbio.2005.02.013

Reddy, 2008, Science, 319, 611, 10.1126/science.1152257

2009, Human Molecular Genetics, 18, 2813, 10.1093/hmg/ddp217

2013, Genetics, 195, 349, 10.1534/genetics.113.154005

2008, JOURNAL OF OVARIAN RESEARCH, 1, 2, 10.1186/1757-2215-1-2

Smith, 1994, Journal of Animal Science, 72, 1857, 10.2527/1994.7271857x

Su, 2004, Developmental biology, 276, 64, 10.1016/j.ydbio.2004.08.020

Sugiura, 2005, Developmental biology, 279, 20, 10.1016/j.ydbio.2004.11.027

2012, Endocrinology, 153, 404, 10.1210/en.2011-1191

2013, Biology of Reproduction, 88, 103, 10.1095/biolreprod.112.105791

2006, REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 4, 19, 10.1186/1477-7827-4-19

Stanfield, 2009, Biology of Reproduction, 81, 16, 10.1095/biolreprod.108.074898

Tomek, 2005, Reproduction, 130, 423, 10.1530/rep.1.00754

Vaccari, 2008, Developmental biology, 316, 124, 10.1016/j.ydbio.2008.01.018

2013, FRONTIERS IN ONCOLOGY, 3, 165article

2012, Journal of Biological Chemistry, 287, 10166, 10.1074/jbc.M111.293274

2014, Journal of Biological Chemistry, 289, 8299, 10.1074/jbc.M113.532952

Watkins, 2006, Fertility and sterility, 86, 1518, 10.1016/j.fertnstert.2006.03.054

Wullschleger, 2006, Cell, 124, 471, 10.1016/j.cell.2006.01.016

Xu, 1995, Biology of Reproduction, 53, 951, 10.1095/biolreprod53.4.951

Yaba, 2008, Reproductive Sciences, 15, 128, 10.1177/1933719107312037

Yan, 2001, Molecular Endocrinology, 15, 854, 10.1210/me.15.6.854

Yu, 2011, 6, e21415, 10.1371/journal.pone.0021415

Schubert, 2013, Biology of Reproduction, 88, 1, 10.1095/biolreprod.112.105957

2013, The Chinese journal of physiology, 56, 298

2013, Gene, 523, 82, 10.1016/j.gene.2013.03.039

2014, Human Molecular Genetics, 23, 920, 10.1093/hmg/ddt486

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Journal of Molecular Endocrinology

Tập 53 Số 3

R103-R118

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