PGC-1α Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis

PLoS Biology - Tập 3 Số 4 - Trang e101
Teresa C. Leone1,2, John J. Lehman1,2, Brian N. Finck1,2, Paul Schaeffer1,2, Adam R. Wende1,2, Sihem Boudina3, Michael Courtois1,2, David F. Wozniak4, Nandakumar Sambandam1,2, Carlos Bernal‐Mizrachi1,2, Zhouji Chen2, John O. Holloszy2, Denis M. Medeiros5, Robert E. Schmidt6, Jeffrey E. Saffitz1,6, E. Dale Abel3, Clay F. Semenkovich1,2, Daniel P. Kelly1,2,7,8
1Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, United States of America
2Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
3Program in Human Molecular Biology and Genetics, Division of Endocrinology, Metabolism and Diabetes, University of Utah, Salt Lake City, Utah, United States of America
4Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, United States of America
5Department of Human Nutrition, Kansas State University, Manhattan, Kansas, United States of America
6Department of Pathology, Washington University School of Medicine, St Louis, Missouri, United States of America
7Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri, United States of America
8Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, United States of America

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PLoS Biology

Tập 3 Số 4

e101

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