P2X7 receptor in cardiovascular disease: The heart side

Clinical and Experimental Pharmacology and Physiology - Tập 46 Số 6 - Trang 513-526 - 2019
Camila Guerra Martinez1
1Department of Microbial Pathogenesis and Immunology Texas A&M University College Station Texas

Tóm tắt

SummaryThe P2X7 receptor is a ligand‐gated purinergic receptor activated by extracellular ATP. The receptor is highly expressed in immune cells and in the brain, and, upon activation, the P2X7 receptor allows a cation flux, leading to the distinct activation of intracellular signalling pathways as the secretion of pro‐inflammatory cytokines, and modulation of cell survival. Through these molecular mechanisms, P2X7 is known to play important roles in physiology and pathophysiology of a wide spectrum of diseases, including cancer, inflammatory diseases, neurological, respiratory and more recently cardiovascular diseases. Recent studies demonstrated that the P2X7 could modulate the assembly of the NLRP3 inflammasome, leading to the secretion of pro‐inflammatory factors and worsen the cardiac disease phenotypes. This review discusses the critical molecular function of P2X7 in the modulation of the onset, progression and resolution of cardiovascular diseases and analyses the putative future use of P2X7‐based therapies that modulate the IL‐1β secretion arm and direct P2X7 antagonists.

Từ khóa


Tài liệu tham khảo

Association AH.Heart Disease and Stroke Statistics 2017 At‐a‐Glance.2017.http://www.heartorg/idc/groups/ahamahpublic/@wcm/@sop/@smd/documents/downloadable/ucm_491265pdf. Accessed July 18 2018.

10.1371/journal.ppat.1002212

10.1126/science.272.5262.735

10.1016/j.neuropharm.2015.07.032

10.1164/rccm.201003-0359OC

10.1159/000086036

10.3892/mmr.2013.1807

10.1016/j.kint.2016.08.029

10.1056/NEJMra1205750

10.1152/ajpgi.00352.2011

10.1517/13543784.2011.578068

10.1016/0306-3623(85)90001-1

10.1124/pr.110.003129

10.1042/bj2330309

10.1111/j.1399-0039.2011.01780.x

10.1016/j.bbamem.2012.01.002

10.1007/5584_2017_59

10.7554/eLife.22153

10.1242/jcs.099374

10.1016/j.immuni.2017.06.020

10.1523/JNEUROSCI.2390-10.2010

Steinberg TH, 1987, Extracellular ATP4‐promotes cation fluxes in the J774 mouse macrophage cell line, J Biol Chem, 262, 3118, 10.1016/S0021-9258(18)61477-2

10.1182/blood.V97.3.587

10.1007/s11302-009-9141-7

10.1590/S0100-879X1998000100004

10.4049/jimmunol.1100478

10.1007/s00210-013-0868-x

10.1089/ars.2013.5549

10.1074/jbc.M211094200

10.1074/jbc.M114.627810

10.1042/bj20030585

10.1074/jbc.M803855200

10.1007/s11302-011-9215-1

10.1016/j.bbrc.2005.04.087

10.4049/jimmunol.169.8.4108

10.1016/j.bbrc.2008.10.042

10.1074/jbc.M901255200

10.1074/jbc.274.10.6653

10.1016/j.bbrc.2015.10.025

10.1111/j.1476-5381.2011.01303.x

10.3389/fphys.2013.00216

10.1124/mol.107.035980

10.3389/fphar.2017.00860

10.1038/nature08198

10.1038/279541a0

10.1111/j.1469-7793.1999.0723n.x

10.1158/1055-9965.EPI-06-0407

10.1210/en.2007-1223

10.1007/s11302-009-9139-1

10.1007/s11302-009-9137-3

10.1152/ajpcell.2000.279.4.C1189

10.1152/ajpcell.2001.280.4.C943

10.1007/s11302-012-9291-x

10.1096/fj.14-267393

10.1111/fcp.12433

10.1016/j.neuropharm.2017.09.030

10.1002/jlb.64.2.265

10.1016/j.bbamem.2009.03.006

10.1016/j.bbamem.2010.07.022

10.1111/j.1365-2249.2011.04440.x

Ozaki E, 2015, Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives, J Inflamm Res, 8, 15

10.4049/jimmunol.176.7.3877

10.4049/jimmunol.159.3.1451

10.4049/jimmunol.179.3.1913

10.1146/annurev.immunol.021908.132612

10.1038/nature18629

10.4049/jimmunol.0901363

10.4049/jimmunol.0900173

Perregaux D, 1994, Interleukin‐1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity, J Biol Chem, 269, 15195, 10.1016/S0021-9258(17)36591-2

10.1038/nature04515

10.1038/sj.emboj.7601378

10.1016/j.immuni.2013.05.016

10.1038/nature16959

10.4049/jimmunol.1402658

10.1073/pnas.1613305114

10.1089/ars.2014.5994

10.3389/fphys.2014.00352

10.1074/jbc.M608083200

10.1038/ni.1631

10.1182/blood-2009-10-250803

10.1038/nature09663

10.1007/978-981-10-4567-7_14

10.1016/j.cell.2013.02.054

10.1038/cddis.2012.144

10.3389/fphar.2017.00123

Couillin I, 2013, ATP release and purinergic signaling in NLRP3 inflammasome activation, Front Immunol, 3, 414

10.15252/embr.201438463

10.4049/jimmunol.1302839

10.1074/jbc.M112.407130

10.1016/j.molcel.2012.11.009

10.1073/pnas.1320294111

10.1038/nature10558

10.1126/science.1240248

10.1126/science.1240988

10.1038/cr.2015.124

10.1016/j.immuni.2016.01.012

10.1002/glia.22628

10.1007/s00018-016-2274-2

10.1016/S1074-7613(03)00235-8

10.4049/jimmunol.175.11.7611

10.1096/fj.12-205765

10.1038/sj.bjp.0707311

10.1073/pnas.1404372111

10.1007/s11302-006-9035-x

10.1016/j.freeradbiomed.2007.02.010

10.1038/srep18417

10.4049/jimmunol.0900394

10.1007/s11302-005-6322-x

10.1016/j.cellsig.2011.11.012

10.1016/j.cca.2018.01.032

10.3389/fphar.2018.00039

10.1016/S1074-7613(03)00266-8

10.4049/jimmunol.172.8.4987

10.4049/jimmunol.0803612

10.1074/jbc.M006781200

10.1016/j.pain.2005.01.002

10.4049/jimmunol.168.12.6436

10.1210/me.2003-0021

10.1074/jbc.M109.033134

10.1189/jlb.0408251

10.1186/1742-2094-5-33

10.1111/j.1476-5381.2011.01624.x

10.4049/jimmunol.176.5.3115

10.1152/physrev.2001.81.2.767

10.1152/ajpcell.1998.275.3.C766

10.1161/01.RES.5.4.349

10.1111/j.1476-5381.1983.tb10514.x

10.1016/S0005-2736(98)00140-0

10.1007/BF00170884

10.1152/ajpheart.2001.281.1.H334

10.1016/j.yjmcc.2009.08.001

10.1007/s11302-015-9468-1

10.1007/s11302-014-9441-4

10.1096/fj.201601307R

10.1007/s00210-009-0403-2

10.1007/s00418-010-0716-8

10.1073/pnas.1108586108

10.1007/s11302-015-9466-3

10.1093/cvr/cvt091

10.1007/s11302-013-9388-x

10.1007/s11302-014-9436-1

10.1007/s11302-007-9078-7

Gu M, 2016, Cardioprotective effects of genistin in rat myocardial ischemia‐reperfusion injury studies by regulation of P2X7/NF‐κB pathway, Evid Based Complement Alternat Med, 2016, 5381290

10.1111/1755-5922.12245

10.1007/s11302-016-9518-3

10.1016/j.neuint.2013.06.003

10.1111/jcmm.13185

10.1016/j.brainresbull.2013.05.004

10.1007/s11302-013-9367-2

10.1007/s00380-014-0527-2

10.1038/srep16940

10.1016/j.ijcard.2013.12.137

10.1113/expphysiol.2012.068338

10.1371/journal.pone.0037491

10.1161/HYPERTENSIONAHA.108.113282

10.1152/ajprenal.00051.2012

10.3389/fphys.2013.00305

10.1111/apha.12412

10.1161/CIRCULATIONAHA.110.982777

10.1038/ncomms13344

10.1084/jem.183.3.949

10.1161/JAHA.118.010595

10.1073/pnas.86.17.6753

10.1097/FJC.0000000000000106

10.1371/journal.pone.0107639

10.1007/s40119-018-0104-3

10.3389/fphys.2018.01115

10.1161/CIRCRESAHA.116.309726

10.1080/13543776.2017.1246538

10.3389/fchem.2018.00248

10.1136/annrheumdis-2011-143578

AstraZeneca.AZD9056: Bethesda MD: National Center for Advancing Translational Sciences (NCATS).2011.http://ncats.nih.gov/files/AZD9056.pdf. Accessed January 23 2019.

Eser A, 2015, Safety and efficacy of an oral inhibitor of the purinergic receptor P2X7 in adult patients with moderately to severely active Crohn's disease: a randomized placebo‐controlled, double‐blind, phase IIa study, Inflamm Bowel Dis, 21, 2247

10.1016/j.coph.2017.10.011

10.3899/jrheum.110874

Pfizer.CE‐224535/P2X7 Receptor Antagonist: Bethesda MD: National Center for Advancing Translational Sciences (NCATS).2011.https://ncats.nih.gov/files/CE-224535.pdf. Accessed January 23 2019.

10.1111/j.1365-2125.2012.04320.x

GlaxoSmithKline.First time in human study evaluating the safety tolerability pharmacokinetics pharmacodynamics and the effect of food of single assending doses of GSK1482160 2009[updated July 7 2017].https://clinicaltrials.gov/ct2/show/NCT00849134.

KincaidJ CaoY KaubC LonerganD KellyMG.Novel compounds as p2x7 modulators and uses thereof. Google Patents.2010.

LanthalerW.Evotec announces the successful completion of the first Phase I study with EVT 401 an Oral P2X7 receptor antagonist ‐ very good safety profile and confirmed “on target activity”. Germany: Evotec.2009[updated June 29 2009].https://www.evotec.com/en/invest/newsannouncements/p/evotec-announces-the-successful-completion-of-the-first-phase-i-study-with-evt-401-an-oral-p2x7-receptor-antagonistvery-good-safety-profile-and-confirmed-on-target-activity-4447.

10.1111/bjd.15364

10.1016/j.ijcard.2013.03.084

10.1161/CIRCULATIONAHA.117.027400

10.1038/s41598-017-05137-y

10.1038/ki.2015.182

10.1074/jbc.M006814200

10.1136/heart.88.3.296

10.1093/cvr/cvv121

10.1152/ajpheart.00305.2011

10.1016/j.bbrc.2013.07.010

10.1016/j.peptides.2016.09.002

10.1177/1074248409360356

10.1016/j.yjmcc.2004.11.005

10.1002/bies.200800236

10.1016/j.ygeno.2003.09.025

10.1242/jcs.01345

10.1136/emj.19.2.129

10.1007/s11897-014-0231-7

Mertens M, 2009, Anakinra for rheumatoid arthritis, Cochrane Database Syst Rev, CD005121

10.1016/j.amjcard.2013.01.287

10.1371/journal.pone.0033438