P2X7 Variants in Oncogenesis
Tóm tắt
Từ khóa
Tài liệu tham khảo
North, 2002, Molecular physiology of P2X receptors, Physiol. Rev., 82, 1013, 10.1152/physrev.00015.2002
Surprenant, 1996, The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7), Science, 272, 735, 10.1126/science.272.5262.735
Jiang, 2019, Structure, function and techniques of investigation of the P2X7 receptor (P2X7R) in mammalian cells, Methods in Enzymology, Volume 629, 115, 10.1016/bs.mie.2019.07.043
Kim, 2001, Proteomic and functional evidence for a P2X7 receptor signalling complex, EMBO J., 20, 6347, 10.1093/emboj/20.22.6347
Adinolfi, 2003, Tyrosine phosphorylation of HSP90 within the P2X7 receptor complex negatively regulates P2X7 receptors, J. Biol. Chem., 278, 37344, 10.1074/jbc.M301508200
Kopp, 2019, P2X7 Interactions and Signaling-Making Head or Tail of It, Front. Mol. Neurosci., 12, 183, 10.3389/fnmol.2019.00183
Adinolfi, 2010, Trophic activity of a naturally occurring truncated isoform of the P2X7 receptor, FASEB J., 24, 3393, 10.1096/fj.09-153601
Steinberg, 1988, Fura-2 secretion and sequestration in macrophages. A blocker of organic anion transport reveals that these processes occur via a membrane transport system for organic anions, J. Immunol., 140, 915, 10.4049/jimmunol.140.3.915
Pelegrin, 2011, Many ways to dilate the P2X7 receptor pore, Br. J. Pharmacol., 163, 908, 10.1111/j.1476-5381.2011.01325.x
Ugur, 2019, A Mechanism-Based Approach to P2X7 Receptor Action, Mol. Pharmacol., 95, 442, 10.1124/mol.118.115022
Adinolfi, 2005, Basal activation of the P2X7 ATP receptor elevates mitochondrial calcium and potential, increases cellular ATP levels, and promotes serum-independent growth, Mol. Biol. Cell, 16, 3260, 10.1091/mbc.e04-11-1025
Karasawa, A., Michalski, K., Mikhelzon, P., and Kawate, T. (2017). The P2X7 receptor forms a dye-permeable pore independent of its intracellular domain but dependent on membrane lipid composition. Elife, 6.
Lara, 2020, P2X7 in Cancer: From Molecular Mechanisms to Therapeutics, Front. Pharmacol., 11, 793, 10.3389/fphar.2020.00793
Orioli, 2016, P2X7 Receptor as a Therapeutic Target, Adv. Protein Chem. Struct. Biol., 104, 39, 10.1016/bs.apcsb.2015.11.004
McCarthy, 2019, Full-Length P2X7 Structures Reveal How Palmitoylation Prevents Channel Desensitization, Cell, 179, 659, 10.1016/j.cell.2019.09.017
Rump, 2020, Evolutionary Origin of the P2X7 C-ter Region: Capture of an Ancient Ballast Domain by a P2X4-Like Gene in Ancient Jawed Vertebrates, Front. Immunol., 11, 113, 10.3389/fimmu.2020.00113
Cheewatrakoolpong, 2005, Identification and characterization of splice variants of the human P2X7 ATP channel, Biochem. Biophys. Res. Commun., 332, 17, 10.1016/j.bbrc.2005.04.087
Sarti, 2017, The P2X7 Receptor in Infection and Inflammation, Immunity, 47, 15, 10.1016/j.immuni.2017.06.020
Adinolfi, 2018, The P2X7 receptor: A main player in inflammation, Biochem. Pharmacol., 151, 234, 10.1016/j.bcp.2017.12.021
Orioli, 2017, P2X7 Receptor Orchestrates Multiple Signalling Pathways Triggering Inflammation, Autophagy and Metabolic/Trophic Responses, Curr. Med. Chem., 24, 2261, 10.2174/0929867324666170303161659
Pizzirani, 2007, Stimulation of P2 receptors causes release of IL-1beta-loaded microvesicles from human dendritic cells, Blood, 109, 3856, 10.1182/blood-2005-06-031377
Gulinelli, 2012, IL-18 associates to microvesicles shed from human macrophages by a LPS/TLR-4 independent mechanism in response to P2X receptor stimulation, Eur. J. Immunol., 42, 3334, 10.1002/eji.201142268
Bianco, 2005, Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia, J. Immunol., 174, 7268, 10.4049/jimmunol.174.11.7268
Savio, 2018, The P2X7 Receptor in Inflammatory Diseases: Angel or Demon?, Front. Pharmacol., 9, 52, 10.3389/fphar.2018.00052
Smith, 2019, Regulation of P2X7 receptor expression and function in the brain, Brain Res. Bull., 151, 153, 10.1016/j.brainresbull.2018.12.008
Deussing, 2018, P2X7 Receptor: A Potential Therapeutic Target for Depression?, Trends Mol. Med., 24, 736, 10.1016/j.molmed.2018.07.005
2019, P2X7 receptor in cardiovascular disease: The heart side, Clin. Exp. Pharmacol. Physiol., 46, 513, 10.1111/1440-1681.13079
Solini, 2019, Role of the P2X7 receptor in the pathogenesis of type 2 diabetes and its microvascular complications, Curr. Opin. Pharmacol., 47, 75, 10.1016/j.coph.2019.02.009
Sarti, 2018, Extracellular ATP and P2 purinergic signalling in the tumour microenvironment, Nat. Rev. Cancer, 18, 601, 10.1038/s41568-018-0037-0
Adinolfi, 2015, Emerging roles of P2X receptors in cancer, Curr. Med. Chem., 22, 878, 10.2174/0929867321666141012172913
Adinolfi, 2012, P2X7 Receptor Function in Bone-Related Cancer, J. Osteoporos, 2012, 637863, 10.1155/2012/637863
Rassendren, 1997, The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA, J. Biol. Chem., 272, 5482, 10.1074/jbc.272.9.5482
Feng, 2006, Endogenously expressed truncated P2X7 receptor lacking the C-terminus is preferentially upregulated in epithelial cancer cells and fails to mediate ligand-induced pore formation and apoptosis, Nucleosides Nucleotides Nucleic Acids, 25, 1271, 10.1080/15257770600890921
Benzaquen, 2019, Alternative splicing of P2RX7 pre-messenger RNA in health and diseases: Myth or reality?, Biomed. J., 42, 141, 10.1016/j.bj.2019.05.007
Giuliani, A.L., Colognesi, D., Ricco, T., Roncato, C., Capece, M., Amoroso, F., Wang, Q.G., De Marchi, E., Gartland, A., and Di Virgilio, F. (2014). Trophic activity of human P2X7 receptor isoforms A and B in osteosarcoma. PLoS ONE, 9.
Ulrich, 2018, Kinin and Purine Signaling Contributes to Neuroblastoma Metastasis, Front. Pharmacol., 9, 500, 10.3389/fphar.2018.00500
Carluccio, M., Zuccarini, M., Ziberi, S., Giuliani, P., Morabito, C., Mariggio, M.A., Lonardo, M.T., Adinolfi, E., Orioli, E., and Di Iorio, P. (2019). Involvement of P2X7 Receptors in the Osteogenic Differentiation of Mesenchymal Stromal/Stem Cells Derived from Human Subcutaneous Adipose Tissue. Stem Cell Rev.
Ziberi, S., Zuccarini, M., Carluccio, M., Giuliani, P., Ricci-Vitiani, L., Pallini, R., Caciagli, F., Di Iorio, P., and Ciccarelli, R. (2019). Upregulation of Epithelial-To-Mesenchymal Transition Markers and P2X7 Receptors Is Associated to Increased Invasiveness Caused by P2X7 Receptor Stimulation in Human Glioblastoma Stem Cells. Cells, 9.
Benzaquen, 2020, P2RX7B is a new theranostic marker for lung adenocarcinoma patients, Theranostics, 10, 10849, 10.7150/thno.48229
Pegoraro, 2020, Differential sensitivity of acute myeloid leukemia cells to daunorubicin depends on P2X7A versus P2X7B receptor expression, Cell Death Dis., 11, 876, 10.1038/s41419-020-03058-9
Pan, 2016, P2RX7-V3 is a novel oncogene that promotes tumorigenesis in uveal melanoma, Tumour Biol., 37, 13533, 10.1007/s13277-016-5141-8
Barden, 2003, Specific detection of non-functional human P2X(7) receptors in HEK293 cells and B-lymphocytes, FEBS Lett., 538, 159, 10.1016/S0014-5793(03)00172-8
Gilbert, S.M., Oliphant, C.J., Hassan, S., Peille, A.L., Bronsert, P., Falzoni, S., Di Virgilio, F., McNulty, S., and Lara, R. (2018). ATP in the tumour microenvironment drives expression of nfP2X7, a key mediator of cancer cell survival. Oncogene.
Bradley, 2011, Residues 155 and 348 contribute to the determination of P2X7 receptor function via distinct mechanisms revealed by single-nucleotide polymorphisms, J. Biol. Chem., 286, 8176, 10.1074/jbc.M110.211284
Gu, 2001, A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptor, J. Biol. Chem., 276, 11135, 10.1074/jbc.M010353200
Sluyter, 2011, Significance of P2X7 receptor variants to human health and disease, Recent Pat. DNA Gene Seq., 5, 41, 10.2174/187221511794839219
Liu, 2013, Association of P2X7 receptor gene polymorphisms with sporadic Parkinson’s disease in a Han Chinese population, Neurosci. Lett., 546, 42, 10.1016/j.neulet.2013.04.049
Ohlendorff, 2007, Single nucleotide polymorphisms in the P2X7 gene are associated to fracture risk and to effect of estrogen treatment, Pharm. Genom., 17, 555, 10.1097/FPC.0b013e3280951625
Gu, 2004, An Arg307 to Gln polymorphism within the ATP-binding site causes loss of function of the human P2X7 receptor, J. Biol. Chem., 279, 31287, 10.1074/jbc.M313902200
Shemon, 2006, A Thr357 to Ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X7 function and impairs ATP-induced mycobacterial killing by macrophages, J. Biol. Chem., 281, 2079, 10.1074/jbc.M507816200
Cabrini, 2005, A His-155 to Tyr polymorphism confers gain-of-function to the human P2X7 receptor of human leukemic lymphocytes, J. Immunol., 175, 82, 10.4049/jimmunol.175.1.82
Chessell, 1998, Cloning and functional characterisation of the mouse P2X7 receptor, FEBS Lett., 439, 26, 10.1016/S0014-5793(98)01332-5
Hu, 2020, The presence of P2RX7 single nuclear polymorphism is associated with a gain of function in P2X7 receptor and inflammasome activation in SLE complicated with pericarditis, Clin. Exp. Rheumatol., 38, 442
Sanz, 2014, Possible protective role of the 489C > T P2X7R polymorphism in Alzheimer’s disease, Exp. Gerontol., 60, 117, 10.1016/j.exger.2014.10.009
Pegoraro, 2020, The P2X7 Receptor 489C > T Gain of Function Polymorphism Favors HHV-6A Infection and Associates with Female Idiopathic Infertility, Front. Pharmacol., 11, 96, 10.3389/fphar.2020.00096
Sorge, 2012, Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity, Nat. Med., 18, 595, 10.1038/nm.2710
Ursu, 2014, Gain and loss of function of P2X7 receptors: Mechanisms, pharmacology and relevance to diabetic neuropathic pain, Mol. Pain, 10, 37, 10.1186/1744-8069-10-37
Stokes, 2010, Two haplotypes of the P2X(7) receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1beta secretion, FASEB J., 24, 2916, 10.1096/fj.09-150862
Sun, 2010, Identification and characterization of a novel variant of the human P2X(7) receptor resulting in gain of function, Purinergic Signal, 6, 31, 10.1007/s11302-009-9168-9
Pellegatti, P., Raffaghello, L., Bianchi, G., Piccardi, F., Pistoia, V., and Di Virgilio, F. (2008). Increased level of extracellular ATP at tumor sites: In vivo imaging with plasma membrane luciferase. PLoS ONE, 3.
Orioli, 2020, Detection of Extracellular ATP in the Tumor Microenvironment, Using the pmeLUC Biosensor, Methods Mol. Biol., 2041, 183, 10.1007/978-1-4939-9717-6_13
Lecciso, 2017, ATP Release from Chemotherapy-Treated Dying Leukemia Cells Elicits an Immune Suppressive Effect by Increasing Regulatory T Cells and Tolerogenic Dendritic Cells, Front. Immunol., 8, 1918, 10.3389/fimmu.2017.01918
Gehring, 2015, P2X7 receptor as predictor gene for glioma radiosensitivity and median survival, Int. J. Biochem. Cell Biol., 68, 92, 10.1016/j.biocel.2015.09.001
Kamata-Sakurai, M., Narita, Y., Hori, Y., Nemoto, T., Uchikawa, R., Honda, M., Hironiwa, N., Taniguchi, K., Shida-Kawazoe, M., and Metsugi, S. (2020). Antibody to CD137 activated by extracellular adenosine triphosphate is tumor selective and broadly effective in vivo without systemic immune activation. Cancer Discov.
Adinolfi, 2019, Role of the P2X7 receptor in tumor-associated inflammation, Curr. Opin. Pharmacol., 47, 59, 10.1016/j.coph.2019.02.012
Vijayan, 2017, Targeting immunosuppressive adenosine in cancer, Nat. Rev. Cancer, 17, 765, 10.1038/nrc.2017.110
Orioli, 2019, The P2X7 receptor modulates immune cells infiltration, ectonucleotidases expression and extracellular ATP levels in the tumor microenvironment, Oncogene, 38, 3636, 10.1038/s41388-019-0684-y
Adinolfi, 2012, Expression of P2X7 receptor increases in vivo tumor growth, Cancer Res., 72, 2957, 10.1158/0008-5472.CAN-11-1947
Baricordi, 1999, Increased proliferation rate of lymphoid cells transfected with the P2X(7) ATP receptor, J. Biol. Chem., 274, 33206, 10.1074/jbc.274.47.33206
Amoroso, 2015, The P2X7 receptor is a key modulator of the PI3K/GSK3beta/VEGF signaling network: Evidence in experimental neuroblastoma, Oncogene, 34, 5240, 10.1038/onc.2014.444
Yang, C., Shi, S., Su, Y., Tong, J.S., and Li, L. (2020). P2X7R promotes angiogenesis and tumour-associated macrophage recruitment by regulating the NF-kappaB signalling pathway in colorectal cancer cells. J. Cell Mol. Med.
Jelassi, 2011, P2X(7) receptor activation enhances SK3 channels- and cystein cathepsin-dependent cancer cells invasiveness, Oncogene, 30, 2108, 10.1038/onc.2010.593
Falzoni, 2016, P2 receptors in cancer progression and metastatic spreading, Curr. Opin. Pharmacol., 29, 17, 10.1016/j.coph.2016.05.001
Xia, 2015, P2X7 receptor stimulates breast cancer cell invasion and migration via the AKT pathway, Oncol. Rep., 34, 103, 10.3892/or.2015.3979
Qiu, Y., Li, W.H., Zhang, H.Q., Liu, Y., Tian, X.X., and Fang, W.G. (2014). P2X7 mediates ATP-driven invasiveness in prostate cancer cells. PLoS ONE, 9.
Adinolfi, 2015, Accelerated tumor progression in mice lacking the ATP receptor P2X7, Cancer Res., 75, 635, 10.1158/0008-5472.CAN-14-1259
Hattori, 2012, Feasibility study of B16 melanoma therapy using oxidized ATP to target purinergic receptor P2X7, Eur. J. Pharmacol., 695, 20, 10.1016/j.ejphar.2012.09.001
Brisson, L., Chadet, S., Lopez-Charcas, O., Jelassi, B., Ternant, D., Chamouton, J., Lerondel, S., Le Pape, A., Couillin, I., and Gombault, A. (2020). P2X7 Receptor Promotes Mouse Mammary Cancer Cell Invasiveness and Tumour Progression, and Is a Target for Anticancer Treatment. Cancers, 12.
Giannuzzo, 2015, The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cells, Mol. Cancer, 14, 203, 10.1186/s12943-015-0472-4
Amoroso, 2016, P2X7 targeting inhibits growth of human mesothelioma, Oncotarget, 7, 49664, 10.18632/oncotarget.10430
Gilbert, 2017, A phase I clinical trial demonstrates that nfP2X7 -targeted antibodies provide a novel, safe and tolerable topical therapy for basal cell carcinoma, Br. J. Dermatol., 177, 117, 10.1111/bjd.15364
Calik, 2020, P2X7 receptor as an independent prognostic indicator in gastric cancer, Bosn. J. Basic Med. Sci., 20, 188
Calik, 2020, A promising independent prognostic biomarker in colorectal cancer: P2X7 receptor, Int. J. Clin. Exp. Pathol., 13, 107
Asif, 2019, Role of purinergic receptors in hepatobiliary carcinoma in Pakistani population: An approach towards proinflammatory role of P2X4 and P2X7 receptors, Purinergic Signal, 15, 367, 10.1007/s11302-019-09675-0
Bae, 2017, P2X7 receptor and NLRP3 inflammasome activation in head and neck cancer, Oncotarget, 8, 48972, 10.18632/oncotarget.16903
Cassinelli, 1981, The discovery of daunorubicin, Cancer Treat Rep., 65, 3
Munerati, 1994, Macrophages loaded with doxorubicin by ATP-mediated permeabilization: Potential carriers for antitumor therapy, Biochim. Biophys. Acta, 1224, 269, 10.1016/0167-4889(94)90200-3
Slater, 2003, Increased expression of apoptotic markers in melanoma, Melanoma Res., 13, 137, 10.1097/00008390-200304000-00005
Slater, 2004, Early prostate cancer detected using expression of non-functional cytolytic P2X7 receptors, Histopathology, 44, 206, 10.1111/j.0309-0167.2004.01798.x
Slater, 2004, Differentiation between cancerous and normal hyperplastic lobules in breast lesions, Breast Cancer Res. Treat, 83, 1, 10.1023/B:BREA.0000010670.85915.0f
Barden, 2016, Therapeutic Targeting of the Cancer-Specific Cell Surface Biomarker nfP2X7, J. Clin. Cell. Immunol., 7, 432, 10.4172/2155-9899.1000432
Amoroso, 2012, The P2X7 receptor is a key modulator of aerobic glycolysis, Cell Death Dis., 3, e370, 10.1038/cddis.2012.105
Zhang, 2019, Highly-expressed P2X7 receptor promotes growth and metastasis of human HOS/MNNG osteosarcoma cells via PI3K/Akt/GSK3beta/beta-catenin and mTOR/HIF1alpha/VEGF signaling, Int. J. Cancer, 145, 1068, 10.1002/ijc.32207
Wiley, 2002, A loss-of-function polymorphic mutation in the cytolytic P2X7 receptor gene and chronic lymphocytic leukaemia: A molecular study, Lancet, 359, 1114, 10.1016/S0140-6736(02)08156-4
Adinolfi, 2005, P2X(7) receptor: Death or life?, Purinergic Signal, 1, 219, 10.1007/s11302-005-6322-x
Thunberg, 2002, Polymorphism in the P2X7 receptor gene and survival in chronic lymphocytic leukaemia, Lancet, 360, 1935, 10.1016/S0140-6736(02)11917-9
Adinolfi, 2002, P2X7 receptor expression in evolutive and indolent forms of chronic B lymphocytic leukemia, Blood, 99, 706, 10.1182/blood.V99.2.706
Starczynski, 2003, The P2X7 receptor gene polymorphism 1513 A-->C has no effect on clinical prognostic markers, in vitro sensitivity to fludarabine, Bcl-2 family protein expression or survival in B-cell chronic lymphocytic leukaemia, Br. J. Haematol., 123, 66, 10.1046/j.1365-2141.2003.04563.x
Zhang, 2003, P2X7 polymorphism and chronic lymphocytic leukaemia: Lack of correlation with incidence, survival and abnormalities of chromosome 12, Leukemia, 17, 2097, 10.1038/sj.leu.2403125
Dardano, 2009, 1513A>C polymorphism in the P2X7 receptor gene in patients with papillary thyroid cancer: Correlation with histological variants and clinical parameters, J. Clin. Endocrinol. Metab., 94, 695, 10.1210/jc.2008-1322
Ghiringhelli, 2009, Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors, Nat. Med., 15, 1170, 10.1038/nm.2028
Paneesha, 2006, The P2X7 receptor gene polymorphism 1513 A-->C has no effect on clinical prognostic markers and survival in multiple myeloma, Leuk. Lymphoma, 47, 281, 10.1080/10428190500305901
Solini, 2015, Genetic interaction of P2X7 receptor and VEGFR-2 polymorphisms identifies a favorable prognostic profile in prostate cancer patients, Oncotarget, 6, 28743, 10.18632/oncotarget.4926