Oxygenation‐sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields

Magnetic Resonance in Medicine - Tập 14 Số 1 - Trang 68-78 - 1990
Seiji Ogawa1, Tso‐Ming Lee1, Asha S. Nayak1,2, Paul Glynn1
1AT&T Bell Laboratories, Murray Hill, New Jersey, 07974
2Department of Biochemistry, Florida State University, Tallahassee, FL 32306 and on AT&T Bell Laboratories Summer Research program (1988)

Tóm tắt

AbstractAt high magnetic fields (7 and 8.4 T), water proton magnetic resonance images of brains of live mice and rats under pentobarbital anesthetization have been measured by a gradient echo pulse sequence with a spatial resolution of 65 × 65‐μm pixel size and 700‐μm slice thickness. The contrast in these images depicts anatomical details of the brain by numerous dark lines of various sizes. These lines are absent in the image taken by the usual spin echo sequence. They represent the blood vessels in the image slice and appear when the deoxyhemoglobin content in the red cells increases. This contrast is most pronounced in an anoxy brain but not present in a brain with diamagnetic oxy or carbon monoxide hemoglobin. The local field induced by the magnetic susceptibility change in the blood due to the paramagnetic deoxyhemoglobin causes the intra voxel dephasing of the water signals of the blood and the surrounding tissue. This oxygena‐tion‐dependent contrast is appreciable in high field images with high spatial resolution. © 1990 Academic Press, Inc.

Từ khóa


Tài liệu tham khảo

10.1002/mrm.1910050304

Raichle M. E., 1985, Brain Imaging and Brain Function, 51

10.1002/mrm.1910060312

10.1016/B978-0-12-547621-8.50008-X

10.1042/bj1800037

10.1016/0304-4165(82)90333-6

10.1118/1.595994

10.1016/0022-2364(86)90373-2

10.1002/mrm.1910060412

Reilly C. A., 1955, Phys. Rev., 98, 264A

10.1021/j150545a036

10.1063/1.1734173

Jackson J. D., 1963, Classical Electrodynamics, 110

S.OgawaandT. M.Lee Magn. Reson. Med. in press.

10.1016/0022-2364(81)90115-3

Siesjö B. K., 1978, Brain Energy Metabolism, 106

Thông tin
Thông tin xuất bản

Magnetic Resonance in Medicine

Tập 14 Số 1

68-78

Thông tin tác giả