Nội dung được dịch bởi AI, chỉ mang tính chất tham khảo
Tiêu thụ Oxy và Sự Chất Lỏng Chloride trong Mô Niệu Đoạn Kết Ruột Nghe Đất ở Chuột
Tóm tắt
Chi phí chuyển hóa hiếu khí của sự tiết chloride đã được nghiên cứu trong mô niệu đoạn kết ruột ngắn của chuột bằng cách đo đồng thời dòng điện ngắn mạch và tiêu thụ oxy trong các điều kiện bảo tồn vận chuyển ion theo phương hướng. Một dung dịch chloride thấp và sự hiện diện của bumetanide cùng diphenylamine-2-carboxylate đã giảm dòng điện ngắn mạch xuống 75% và tiêu thụ oxy xuống 25%. Ouabain giảm dòng điện ngắn mạch xuống 93% và tiêu thụ oxy xuống 32%. Serotonin đã tăng cả hai biến này lên 59% và 33%, tương ứng. Bumetanide và diphenylamine-2-carboxylate đã giảm nhưng không loại bỏ hoàn toàn tác động của serotonin lên dòng điện ngắn mạch và tiêu thụ oxy. Sự thay đổi trong dòng điện ngắn mạch và tiêu thụ oxy có tương quan tuyến tính trong tất cả các điều kiện đã được kiểm tra. Kết luận rằng, trong biểu mô ruột kết ngắn của chuột không được kích thích, sự tiết chloride chiếm khoảng 75% dòng điện ngắn mạch nhạy cảm với ouabain và tiêu thụ oxy. Sự tiết chloride bị kích thích có thể chiếm hơn 40% tổng tiêu thụ oxy.
Từ khóa
Tài liệu tham khảo
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