Oxidative Stress and Diabetic Retinopathy

Journal of Diabetes Research - Tập 2007 Số 1 - 2007
Renu A. Kowluru1, Pooi-See Chan1
1Kresge Eye Institute, Wayne State University

Tóm tắt

Oxygen metabolism is essential for sustaining aerobic life, and normal cellular homeostasis works on a fine balance between the formation and elimination of reactive oxygen species (ROS). Oxidative stress, a cytopathic consequence of excessive production of ROS and the suppression of ROS removal by antioxidant defense system, is implicated in the development of many diseases, including Alzheimer′s disease, and diabetes and its complications. Retinopathy, a debilitating microvascular complication of diabetes, is the leading cause of acquired blindness in developed countries. Many diabetes‐induced metabolic abnormalities are implicated in its development, and appear to be influenced by elevated oxidative stress; however the exact mechanism of its development remains elusive. Increased superoxide concentration is considered as a causal link between elevated glucose and the other metabolic abnormalities important in the pathogenesis of diabetic complications. Animal studies have shown that antioxidants have beneficial effects on the development of retinopathy, but the results from very limited clinical trials are somewhat ambiguous. Although antioxidants are being used for other chronic diseases, controlled clinical trials are warranted to investigate potential beneficial effects of antioxidants in the development of retinopathy in diabetic patients.

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Tài liệu tham khảo

10.1097/01.icu.0000161227.21797.3d

10.1056/NEJMra021678

10.1038/sj.eye.6701969

Robison W. G., 1985, Early retinal microangiopathy: prevention with aldose reductase inhibitors, Diabetic Medicine, 2, 196, 10.1111/j.1464-5491.1985.tb00635.x

10.1016/j.biocel.2003.08.007

Aiello L. P., 1998, Diabetic retinopathy, Diabetes Care, 21, 143, 10.2337/diacare.21.1.143

Frank R. N., 1991, On the pathogenesis of diabetic retinopathy: a 1990 update, Ophthalmology, 98, 586, 10.1016/S0161-6420(91)32253-X

Engerman R. L., 1971, Diabetes, Proceedings of the 7th Congress of the International Diabetes Federation, 261

Kern T. S., 1994, Questions Raised by Studies of Experimental Diabetic Retinopathy

Mizutani M., 1996, Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy, Journal of Clinical Investigation, 97, 2883, 10.1172/JCI118746

Kern T. S., 2000, Response of capillary cell death to aminoguanidine predicts the development of retinopathy: comparison of diabetes and galactosemia, Investigative Ophthalmology & Visual Science, 41, 3972

Kowluru R. A., 2004, Effect of long-term administration of α-lipoic acid on retinal capillary cell death and the development of retinopathy in diabetic rats, Diabetes, 53, 3233, 10.2337/diabetes.53.12.3233

10.1096/fj.03-1476fje

Xia P., 1994, Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia, Diabetes, 43, 1122, 10.2337/diab.43.9.1122

Kowluru R. A., 1998, Abnormalities of retinal metabolism in diabetes or experimental galactosemia. V. Relationship between protein kinase C and APTases, Diabetes, 47, 464, 10.2337/diabetes.47.3.464

Kowluru R. A., 2001, Abnormalities of retinal metabolism in diabetes and experimental galactosemia. VII. Effect of long-term administration of antioxidants on the development of retinopathy, Diabetes, 50, 1938, 10.2337/diabetes.50.8.1938

10.1007/s592-001-8076-6

Kowluru R. A., 2004, Potential contributory role of H-Ras, a small G-protein, in the development of retinopathy in diabetic rats, Diabetes, 53, 775, 10.2337/diabetes.53.3.775

10.1080/10715760310001604189

10.1080/1071576021000006572

10.1097/00006982-200607001-00016

Diabetes Control, 1997, Hypoglycemia in the diabetes control and complications trial, Diabetes, 46, 271, 10.2337/diab.46.2.271

Dröge W., 2002, Free radicals in the physiological control of cell function, Physiological Reviews, 82, 47, 10.1152/physrev.00018.2001

10.1196/annals.1323.027

Baynes J. W., 1991, Role of oxidative stress in development of complications in diabetes, Diabetes, 40, 405, 10.2337/diab.40.4.405

10.1172/JCI200317863

10.1016/S0168-8227(99)00044-3

10.1007/s00125-002-0831-8

10.1385/CT:1:3:181

Kowluru R. A., 2003, Effect of reinstitution of good glycemic control on retinal oxidative stress and nitrative stress in diabetic rats, Diabetes, 52, 818, 10.2337/diabetes.52.3.818

Wohaieb S. A., 1987, Alterations in free radical tissue-defense mechanisms in streptozocin-induced diabetes in rat. Effects of insulin treatment, Diabetes, 36, 1014, 10.2337/diab.36.9.1014

Baynes J. W., 1999, Role of oxidative stress in diabetic complications: a new perspective on an old paradigm, Diabetes, 48, 1, 10.2337/diabetes.48.1.1

10.1196/annals.1288.006

10.1038/414813a

Anderson R. E., 1984, Lipid peroxidation and retinal degeneration, Current Eye Research, 3, 223, 10.3109/02713688408997203

10.1167/iovs.03-0353

10.1016/j.freeradbiomed.2003.08.018

10.1016/j.exer.2006.03.024

10.1016/S0891-5849(99)00216-6

Kowluru R. A., 2002, Termination of experimental galactosemia in rats, and progression of retinal metabolic abnormalities, Investigative Ophthalmology & Visual Science, 43, 3287

Meister A., 1988, Glutathione metabolism and its selective modification, Journal of Biological Chemistry, 263, 17205, 10.1016/S0021-9258(19)77815-6

Kern T. S., 1994, Abnormalities of retinal metabolism in diabetes or galactosemia: ATPases and glutathione, Investigative Ophthalmology & Visual Science, 35, 2962

Kowluru R. A., 1994, Abnormalities of retinal metabolism in diabetes or galactosemia II. Comparison of γ-glutamyl transpeptidase in retina and cerebral cortex, and effects of antioxidant therapy, Current Eye Research, 13, 891, 10.3109/02713689409015092

10.1016/S0891-5849(96)00347-4

Ford E. S., 2003, The metabolic syndrome and antioxidant concentrations: findings from the Third National Health and Nutrition Examination Survey, Diabetes, 52, 2346, 10.2337/diabetes.52.9.2346

10.1007/s001250050084

10.1016/S09254439(02)00219-3

10.1111/j.1432-1033.1994.tb20064.x

Koya D., 1998, Protein kinase C activation and the development of diabetic complications, Diabetes, 47, 859, 10.2337/diabetes.47.6.859

10.1073/pnas.97.22.12222

10.2174/1389450054021981

10.1046/j.1471-4159.2001.00325.x

10.1089/ars.2005.7.1581

10.1016/S0168-8227(02)00248-6

10.1074/jbc.270.17.10017

10.1016/S0014-4800(03)00035-2

Mohamed A. K., 1999, The role of oxidative stress and NF-κB activation in late diabetic complications, BioFactors, 10, 157, 10.1002/biof.5520100211

10.1016/j.lfs.2004.10.017

Cowell R. M., 2004, Nitrosative injury and antioxidant therapy in the management of diabetic neuropathy, Journal of Investigative Medicine, 52, 33, 10.1177/108155890405200124

10.1126/science.272.5262.728

Kowluru R. A., 1996, Abnormalities of retinal metabolism in diabetes or experimental galactosemia. III. Effects of antioxidants, Diabetes, 45, 1233, 10.2337/diab.45.9.1233

10.1016/0006-291X(92)90463-U

Oikawa T., 1992, Inhibition of angiogenesis by staurosporine, a potent protein kinase inhibitor, Journal of Antibiotics, 45, 1155, 10.7164/antibiotics.45.1155

Xia P., 1996, Characterization of vascular endothelial growth factor′s effect on the activation of protein kinase C, its isoforms, and endothelial cell growth, Journal of Clinical Investigation, 98, 2018, 10.1172/JCI119006

Koya D., 1997, Characterization of protein kinase C β isoform activation on the gene expression of transforming growth factor-β, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats, Journal of Clinical Investigation, 100, 115, 10.1172/JCI119503

10.1254/jphs.FP0050896

10.2337/db06-0895

10.1172/JCI200318127

Brownlee M., 2005, The pathobiology of diabetic complications: a unifying mechanism, Diabetes, 54, 1615, 10.2337/diabetes.54.6.1615

Beisswenger P. J., 2005, Susceptibility to diabetic nephropathy is related to dicarbonyl and oxidative stress, Diabetes, 54, 3274, 10.2337/diabetes.54.11.3274

10.1016/S0006-2952(99)00060-X

Lutty G. A., 1996, Localization of vascular endothelial growth factor in human retina and choroid, Archives of Ophthalmology, 114, 971, 10.1001/archopht.1996.01100140179011

10.1046/j.1523-1755.2000.07718.x

Lu M., 1998, Advanced glycation end products increase retinal vascular endothelial growth factor expression, Journal of Clinical Investigation, 101, 1219, 10.1172/JCI1277

Aiello L. P., 1997, Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective β-isoform-selective inhibitor, Diabetes, 46, 1473, 10.2337/diab.46.9.1473

Frank R. N., 1997, An aldose reductase inhibitor and aminoguanidine prevent vascular endothelial growth factor expression in rats with long-term galactosemia, Archives of Ophthalmology, 115, 1036, 10.1001/archopht.1997.01100160206011

10.1210/en.140.10.4622

10.1089/ars.2006.8.1857

10.1016/S0003-9861(02)00338-7

10.2174/1381612043384664

KanwarM. ChanP.-S. KernT. S. andKowluruR. A. Oxidative damage in the retinal mitochondria of diabetic mice: possible protection by superoxide dismutase submitted toInvestigative Ophthalmology & Visual Science.

10.1167/iovs.05-1276

10.1016/j.freeradbiomed.2006.01.012

Maassen J. A., 2004, Mitochondrial diabetes: molecular mechanisms and clinical presentation, Diabetes, 53, S103, 10.2337/diabetes.53.2007.S103

10.1016/j.jdiacomp.2004.03.002

10.1167/iovs.04-1361

Podesta F., 2000, Bax is increased in the retina of diabetic subjects and is associated with pericyte apoptosis in vivo and in vitro, American Journal of Pathology, 156, 1025, 10.1016/S0002-9440(10)64970-X

Barber A. J., 1998, Neural apoptosis in the retina during experimental and human diabetes: early onset and effect of insulin, Journal of Clinical Investigation, 102, 783, 10.1172/JCI2425

Mizutani M., 1998, Muller cell changes in human diabetic retinopathy, Diabetes, 47, 445, 10.2337/diabetes.47.3.445

10.1167/iovs.04-0842

10.1080/10715769900300081

Kaneto H., 1999, Beneficial effects of antioxidants in diabetes: possible protection of pancreatic β-cells against glucose toxicity, Diabetes, 48, 2398, 10.2337/diabetes.48.12.2398

10.1016/S0891-5849(01)00646-3

Li W., 1999, Altered mRNA levels of antioxidant enzymes in pre-apoptotic pericytes from human diabetic retinas, Cellular and Molecular Biology, 45, 59

10.1016/S0891-5849(01)00591-3

Phaneuf S., 2002, Cytochrome c release from mitochondria in the aging heart: a possible mechanism for apoptosis with age, American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 282, R423, 10.1152/ajpregu.00296.2001

10.1002/(SICI)1097-4644(199701)64:1<33::AID-JCB6>3.0.CO;2-0

10.1006/bbrc.1997.7304

10.1016/S0891-5849(96)00429-7

10.1016/S0891-5849(99)00079-9

Romeo G., 2002, Activation of nuclear factor-κB induced by diabetes and high glucose regulates a proapoptotic program in retinal pericytes, Diabetes, 51, 2241, 10.2337/diabetes.51.7.2241

10.1073/pnas.93.8.3308

Beckman J. S., 1996, Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and the ugly, American Journal of Physiology - Cell Physiology, 271, C1424, 10.1152/ajpcell.1996.271.5.C1424

10.1006/bbrc.1996.1438

10.1016/S0891-5849(02)01111-5

10.1007/s00592-004-0165-8

10.1046/j.0022-3042.2001.00737.x

Joussen A. M., 2001, Leukocyte-mediated endothelial cell injury and death in the diabetic retina, American Journal of Pathology, 158, 147, 10.1016/S0002-9440(10)63952-1

10.1016/j.athoracsur.2003.09.128

10.1016/S0361-9230(02)00951-6

Schreck R., 1992, Nuclear factor κ β: an oxidative stress-responsive transcription factor of eukaryotic cells (a review), Free Radical Research Communications, 17, 221, 10.3109/10715769209079515

10.1016/S1056-8727(01)00155-6

10.1016/S0042-6989(99)00117-0

10.1136/bjo.2003.038133

Vassilakopoulos T., 2003, Antioxidants attenuate the plasma cytokine response to exercise in humans, Journal of Applied Physiology, 94, 1025, 10.1152/japplphysiol.00735.2002

10.1167/iovs.04-0633

10.2174/1381612043383142

10.1016/0891-5849(95)00017-R

10.1007/s00125-006-0174-y

10.1016/S0891-5849(02)01195-4

10.1038/nm834

10.1016/S0378-8741(02)00217-9

Mustata G. T., 2005, Paradoxical effects of green tea (Camellia sinensis) and antioxidant vitamins in diabetic rats: improved retinopathy and renal mitochondrial defects but deterioration of collagen matrix glycoxidation and cross-linking, Diabetes, 54, 517, 10.2337/diabetes.54.2.517

Ansari N. H., 1998, Prevention of pericyte loss by Trolox in diabetic rat retina, Journal of Toxicology and Environmental Health—Part A, 54, 467, 10.1080/009841098158755

10.1007/s001250050726

10.1016/j.taap.2004.05.014

10.1016/j.mehy.2002.11.003

10.1016/S0891-5849(98)00210-X

10.2165/00024677-200504040-00003

10.1002/ptr.853

Bursell S.-E., 1999, High-dose vitamin E supplementation normalizes retinal blood flow and creatinine clearance in patients with type 1 diabetes, Diabetes Care, 22, 1245, 10.2337/diacare.22.8.1245

10.1093/aje/kwg116

Millen A. E., 2004, Relation between intake of vitamins C and E and risk of diabetic retinopathy in the Atherosclerosis Risk in Communities Study, American Journal of Clinical Nutrition, 79, 865, 10.1093/ajcn/79.5.865

10.1016/S0161-6420(98)91227-1