Outbreak of Poliomyelitis in Hispaniola Associated with Circulating Type 1 Vaccine-Derived Poliovirus

American Association for the Advancement of Science (AAAS) - Tập 296 Số 5566 - Trang 356-359 - 2002
Olen M. Kew1, Victoria Morris‐Glasgow2, Mauricio Landaverde3, Cara C. Burns1, Jing Shaw1, Zacarı́as Garib4, Jean André5, Elizabeth Blackman2, C. Jason Freeman1, Jaume Jorba1, Roland W. Sutter6, Gina Tambini3, Linda Venczel3, Cristina Pedreira7, Fernando Laender8, Hiroyuki Shimizu9, Tetsuo Yoneyama9, Tatsuo Miyamura9, Harrie van der Avoort10, M. Steven Oberste1, David R. Kilpatrick1, Stephen L. Cochi6, Mark A. Pallansch1, Ciro de Quadros3
1Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), 1600 Clifton Road, Atlanta, GA 30333, USA.
2Caribbean Epidemiology Centre (CAREC) Laboratory, Pan American Health Organization (PAHO), 16-18 Jamaica Boulevard, Federation Park, Port-of-Spain, Trinidad and Tobago.
3Division of Vaccines and Immunization, PAHO, 525 Twenty-Third Street, N.W., Washington, DC 20037, USA.
4Ministry of Health, Avenida San Cristóbal esquina Tiradentes, Santo Domingo, Dominican Republic.
5Ministry of Public Health, Port-au-Prince, Haiti.
6Vaccine Preventable Disease Eradication Division, National Immunization Program, CDC, 1600 Clifton Road, Atlanta, GA 30333, USA.
7PAHO, Calle Pepillo Salcedo, Plaza de la Salud, Santo Domingo, Dominican Republic.
8PAHO, Number 295 Avenue John Brown, Port-au-Prince, Haiti.
9Department of Virology II, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162, Japan.
10Polio Laboratory, National Institute of Public Health and the Environment (RIVM), Antonie van Leeuwenhoeklaan 9, 3720 BA, Bilthoven, Netherlands.

Tóm tắt

An outbreak of paralytic poliomyelitis occurred in the Dominican Republic (13 confirmed cases) and Haiti (8 confirmed cases, including 2 fatal cases) during 2000–2001. All but one of the patients were either unvaccinated or incompletely vaccinated children, and cases occurred in communities with very low (7 to 40%) rates of coverage with oral poliovirus vaccine (OPV). The outbreak was associated with the circulation of a derivative of the type 1 OPV strain, probably originating from a single OPV dose given in 1998–1999. The vaccine-derived poliovirus associated with the outbreak had biological properties indistinguishable from those of wild poliovirus.

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We thank N. Dybdahl-Sissoko N. Mishrik D. Moore M. Staples and A. J. Williams for characterization of poliovirus isolates before sequencing; J. Kim and J. Golub for sequencing some of the wild poliovirus type 1 isolates; R. Campagnoli for performing growth-rate studies of poliovirus isolates; P. Chenoweth for assistance with the mapping of the confirmed polio cases; L. Anderson V. Cáceres W. Dowdle H. Gary C. Maher and R. Sanders for helpful discussions; two anonymous reviewers for their constructive comments; and the virologists from the WHO Global Polio Laboratory Network for contributing the wild poliovirus isolates used in our comparisons.

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American Association for the Advancement of Science (AAAS)

Tập 296 Số 5566

356-359

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