Orthopaedic regenerative tissue engineering en route to the holy grail: disequilibrium between the demand and the supply in the operating room

Abraham GA, Murray J, Billiar K, Sullivan SJ (2000) Evaluation of the porcine intestinal collagen layer as a biomaterial. J Biomed Mater Res 51(3):442–452 Amini AR, Laurencin CT, Nukavarapu SP (2012) Bone tissue engineering: recent advances and challenges. Crit Rev Biomed Eng 40(5):363–408 Anderson DE, Williams RJ III, DeBerardino TM, Taylor DC, Ma CB, Kane MS, Crawford DC (2017) Magnetic resonance imaging characterization and clinical outcomes after NeoCart surgical therapy as a primary reparative treatment for knee cartilage injuries. Am J Sports Med 45(4):875–883 Andia I, Maffulli N (2013) Platelet-rich plasma for managing pain and inflammation in osteoarthritis. Nat Rev Rheumatol 9(12):721–730 Annabi N, Tamayol A, Uquillas JA, Akbari M, Bertassoni LE, Cha C, Camci-Unal G, Dokmeci MR, Peppas NA, Khademhosseini A (2014) 25th anniversary article: rational design and applications of hydrogels in regenerative medicine. Adv Mater 26(1):85–124 Athanasiou KA, Eswaramoorthy R, Hadidi P, Hu JC (2013) Self-organization and the self-assembling process in tissue engineering. Annu Rev Biomed Eng 15:115–136 Bacelar AH, Cengiz IF, Silva-Correia J, Sousa RA, Oliveira JM, Reisa RL (2017) “Smart” hydrogels in tissue engineering and regenerative medicine applications. Handbook of intelligent scaffolds for tissue engineering and regenerative medicine 2:327–361 Badhe SP, Lawrence TM, Smith F, Lunn P (2008) An assessment of porcine dermal xenograft as an augmentation graft in the treatment of extensive rotator cuff tears. J Shoulder Elb Surg 17(1):S35–S39 Barber FA, Aziz-Jacobo J (2009) Biomechanical testing of commercially available soft-tissue augmentation materials. Arthroscopy 25(11):1233–1239 Barber FA, Burns JP, Deutsch A, Labbé MR, Litchfield RB (2012) A prospective, randomized evaluation of acellular human dermal matrix augmentation for arthroscopic rotator cuff repair. Arthroscopy 28(1):8–15 Barber FA, Herbert MA, Coons DA (2006) Tendon augmentation grafts: biomechanical failure loads and failure patterns. Arthroscopy 22(5):534–538 Basad E, Ishaque B, Bachmann G, Stürz H, Steinmeyer J (2010) Matrix-induced autologous chondrocyte implantation versus microfracture in the treatment of cartilage defects of the knee: a 2-year randomised study. Knee Surg Sports Traumatol Arthrosc 18(4):519–527 Bayon Y, Vertès AA, Ronfard V, Egloff M, Snykers S, Salinas GF, Thomas R, Girling A, Lilford R, Clermont G (2014) Translating cell-based regenerative medicines from research to successful products: challenges and solutions. Tissue Eng B Rev 20(4):246–256 Becher C, Laute V, Fickert S, Zinser W, Niemeyer P, John T, Diehl P, Kolombe T, Siebold R, Fay J (2017) Safety of three different product doses in autologous chondrocyte implantation: results of a prospective, randomised, controlled trial. J Orthop Surg Res 12(1):71 Beitzel K, Chowaniec DM, McCarthy MB, Cote MP, Russell RP, Obopilwe E, Imhoff AB, Arciero RA, Mazzocca AD (2012) Stability of double-row rotator cuff repair is not adversely affected by scaffold interposition between tendon and bone. Am J Sports Med 40(5):1148–1154 Bond JL, Dopirak RM, Higgins J, Burns J, Snyder SJ (2008) Arthroscopic replacement of massive, irreparable rotator cuff tears using a GraftJacket allograft: technique and preliminary results. Arthroscopy 24(4):403 e401–403. e408 Bouyarmane H, Beaufils P, Pujol N, Bellemans J, Roberts S, Spalding T, Zaffagnini S, Marcacci M, Verdonk P, Womack M, Verdonk R (2014) Polyurethane scaffold in lateral meniscus segmental defects: clinical outcomes at 24 months follow-up. Orthop Traumat Surg Res 100(1):153–157 Brittberg M (2010) Cell carriers as the next generation of cell therapy for cartilage repair: a review of the matrix-induced autologous chondrocyte implantation procedure. The American journal of sports medicine 38(6):1259–1271 Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L (1994) Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 331(14):889–895 Büchler MW, Diener MK, Weitz J (2011) Scientific evaluation of modern clinical research: we need a new currency! Langenbeck's Arch Surg 396(7):937 Bulgheroni P, Bulgheroni E, Regazzola G, Mazzola C (2013) Polyurethane scaffold for the treatment of partial meniscal tears. Clinical results with a minimum two-year follow-up. Joints 1(4):161–166 Burks SR, Ziadloo A, Kim SJ, Nguyen BA, Frank JA (2013) Noninvasive pulsed focused ultrasound allows spatiotemporal control of targeted homing for multiple stem cell types in murine skeletal muscle and the magnitude of cell homing can be increased through repeated applications. Stem Cells 31(11):2551–2560 Caddeo S, Boffito M, Sartori S (2017) Tissue engineering approaches in the Design of Healthy and Pathological in Vitro Tissue Models. Front Bioeng Biotechnol 5:40 Canata GL, Casale V, De Carli A, Zanon G, Benazzo F, Rivellino MC, Vascellari A, Oliva F (2017) Emerging Orthobiologic approaches to tendon injuries. In: Gobbi A, Espregueira-Mendes J, Lane JG, Karahan M (eds) Bio-orthopaedics: a new approach. Springer Berlin Heidelberg, Berlin, Heidelberg, pp 275–288 Caplan AI (2007) Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. J Cell Physiol 213(2):341–347 Cengiz IF, Oliveira JM, Ochi M, Nakamae A, Adachi N, Reis RL (2017a) “Biologic” treatment for meniscal repair. In: Injuries and health problems in football. Springer, Berlin, pp 679–686 Cengiz IF, Oliveira JM, Reis RL (2014) Tissue engineering and regenerative medicine strategies for the treatment of osteochondral lesions. In: 3D multiscale physiological human. Springer, London, pp 25–47 Cengiz IF, Pereira H, Espregueira-Mendes J, Oliveira JM, Reis RL (2017b) Treatments of meniscus lesions of the knee: current concepts and future perspectives. Regenerative Eng Translational Med 3(1)1–19:32–50 Cengiz IF, Pereira H, Pitikakis M, Espregueira-Mendes J, Oliveira JM, Reis RL (2017c) Building the basis for patient-specific meniscal scaffolds. In: Gobbi A, Espregueira-Mendes J, Lane JG, Karahan M (eds) Bio-orthopaedics: a new approach. Springer Berlin Heidelberg, Berlin, Heidelberg, pp 411–418 Cengiz IF, Pereira H, Silva-Correia J, Ripoll PL, Espregueira-Mendes J, Kaz R, Oliveira JM, Reis RL (2017d) Meniscal lesions: from basic science to clinical Management in Footballers. In: Injuries and health problems in football. Springer, Berlin, pp 145–163 Cengiz IF, Pitikakis M, Cesario L, Parascandolo P, Vosilla L, Viano G, Oliveira J, Reis R (2016) Building the basis for patient-specific meniscal scaffolds: from human knee MRI to fabrication of 3D printed scaffolds. Bioprinting 1, 1-10 Cengiz IF, Silva-Correia J, Pereira H, Espregueira-Mendes J, Oliveira JM, Reis RL (2017e) Advanced regenerative strategies for human knee meniscus. In: Regenerative strategies for the treatment of knee joint disabilities. Springer, Cham, pp 271–285 Chahla J, Cinque ME, Piuzzi NS, Mannava S, Geeslin AG, Murray IR, Dornan GJ, Muschler GF, LaPrade RF (2017) A call for standardization in platelet-rich plasma preparation protocols and composition reporting: a systematic review of the clinical Orthopaedic literature. JBJS 99(20):1769–1779 Chen F-M, Wu L-A, Zhang M, Zhang R, Sun H-H (2011) Homing of endogenous stem/progenitor cells for in situ tissue regeneration: promises, strategies, and translational perspectives. Biomaterials 32(12):3189–3209 Chen J, Xu J, Wang A, Zheng M (2009) Scaffolds for tendon and ligament repair: review of the efficacy of commercial products. Exp Rev Med Devices 6(1):61–73 Chen T, Jiang J, Chen S (2015) Status and headway of the clinical application of artificial ligaments. Asia Pac J Sports Med Arthroscopy Rehabil Technol 2(1):15–26 Cole BJ, Farr J, Winalski C, Hosea T, Richmond J, Mandelbaum B, De Deyne PG (2011) Outcomes after a single-stage procedure for cell-based cartilage repair: a prospective clinical safety trial with 2-year follow-up. Am J Sports Med 39(6):1170–1179 Corona BT, Greising SM (2016) Challenges to acellular biological scaffold mediated skeletal muscle tissue regeneration. Biomaterials 104:238–246 Crawford DC, DeBerardino TM, Williams RJ III (2012) NeoCart, an autologous cartilage tissue implant, compared with microfracture for treatment of distal femoral cartilage lesions: an FDA phase-II prospective, randomized clinical trial after two years. JBJS 94(11):979–989 Crawford DC, Heveran CM, Dilworth Cannon W, Foo LF, Potter HG (2009) An autologous cartilage tissue implant NeoCart for treatment of grade III chondral injury to the distal femur. Am J Sports Med 37(7):1334–1343 Cross LM, Thakur A, Jalili NA, Detamore M, Gaharwar AK (2016) Nanoengineered biomaterials for repair and regeneration of orthopedic tissue interfaces. Acta Biomater 42:2–17 Derwin KA, Baker AR, Spragg RK, Leigh DR, Iannotti JP (2006) Commercial extracellular matrix scaffolds for rotator cuff tendon repair: biomechanical, biochemical, and cellular properties. JBJS 88(12):2665–2672 Devitt BM, Bell SW, Webster KE, Feller JA, Whitehead TS (2017) Surgical treatments of cartilage defects of the knee: systematic review of randomised controlled trials. Knee 24(3):508–517 Díaz-Zuccarini V, Lawford PV (2010) An in silico future for the engineering of functional tissues and organs. Organogenesis 6(4):245–251 Dominkus M, Sabeti M, Toma C, Abdolvahab F, Trieb K, Kotz RI (2006) Reconstructing the extensor apparatus with a new polyester ligament. Clin Orthop Relat Res® 453:328–334 Encalada-Diaz I, Cole BJ, MacGillivray JD, Ruiz-Suarez M, Kercher JS, Friel NA, Valero-Gonzalez F (2011) Rotator cuff repair augmentation using a novel polycarbonate polyurethane patch: preliminary results at 12 months’ follow-up. J Shoulder Elb Surg 20(5):788–794 Ergina PL, Cook JA, Blazeby JM, Boutron I, Clavien P-A, Reeves BC, Seiler CM, Collaboration B (2009) Challenges in evaluating surgical innovation. Lancet 374(9695):1097–1104 Eshed I, Trattnig S, Sharon M, Arbel R, Nierenberg G, Konen E, Yayon A (2012) Assessment of cartilage repair after chondrocyte transplantation with a fibrin-hyaluronan matrix–correlation of morphological MRI, biochemical T2 mapping and clinical outcome. Eur J Radiol 81(6):1216–1223 Farr J, Cole BJ, Sherman S, Karas V (2012) Particulated articular cartilage: CAIS and DeNovo NT. J Knee Surg 25(01):023–030 Fernandez-Yague MA, Abbah SA, McNamara L, Zeugolis DI, Pandit A, Biggs MJ (2015) Biomimetic approaches in bone tissue engineering: integrating biological and physicomechanical strategies. Adv Drug Deliv Rev 84:1–29 Fickert S, Gerwien P, Helmert B, Schattenberg T, Weckbach S, Kaszkin-Bettag M, Lehmann L (2012) One-year clinical and radiological results of a prospective, investigator-initiated trial examining a novel, purely autologous 3-dimensional autologous chondrocyte transplantation product in the knee. Cartilage 3(1):27–42 Fong EL, Chan CK, Goodman SB (2011) Stem cell homing in musculoskeletal injury. Biomaterials 32(2):395–409 Gao K, Chen S, Wang L, Zhang W, Kang Y, Dong Q, Zhou H, Li L (2010) Anterior cruciate ligament reconstruction with LARS artificial ligament: a multicenter study with 3-to 5-year follow-up. Arthroscopy 26(4):515–523 Gelber PE, Petrica AM, Isart A, Mari-Molina R, Monllau JC (2015) The magnetic resonance aspect of a polyurethane meniscal scaffold is worse in advanced cartilage defects without deterioration of clinical outcomes after a minimum two-year follow-up. Knee 22(5):389–394 Geris L (2014) Regenerative orthopaedics: in vitro, in vivo… in silico. Int Orthop 38(9):1771–1778 Geris L, Guyot Y, Schrooten J, Papantoniou I (2016) In silico regenerative medicine: how computational tools allow regulatory and financial challenges to be addressed in a volatile market. Interface Focus 6(2):20150105 Giannini S, Buda R, Vannini F, Cavallo M, Grigolo B (2009) One-step bone marrow-derived cell transplantation in talar osteochondral lesions. Clin Orthop Relat Res 467(12):3307–3320 Giannotti S, Ghilardi M, Dell'Osso G, Magistrelli L, Bugelli G, Di FR, Ricci G, Calabrese R, Siciliano G, Guido G (2014) Study of the porcine dermal collagen repair patch in morpho-functional recovery of the rotator cuff after minimum follow-up of 2 5 years. Surg Technol Int 24:348–352 Gobbi A, Espregueira-Mendes J, Lane JG, Karahan M (2017) Bio-orthopaedics: a new approach. Springer, Berlin Gobbi A, Whyte GP (2016) One-stage cartilage repair using a hyaluronic acid–based scaffold with activated bone marrow–derived mesenchymal stem cells compared with microfracture: five-year follow-up. Am J Sports Med 44(11):2846–2854 Gobbi A, Whyte GP (2017) Emerging Orthobiologic approaches to ligament injury. In: Gobbi A, Espregueira-Mendes J, Lane JG, Karahan M (eds) Bio-orthopaedics: a new approach. Springer Berlin Heidelberg, Berlin, pp 313–324 Gothard D, Smith E, Kanczler J, Rashidi H, Qutachi O, Henstock J, Rotherham M, El Haj A, Shakesheff K, Oreffo R (2014) Tissue engineered bone using select growth factors: a comprehensive review of animal studies and clinical translation studies in man. Eur Cells Mater 28:166–208 Grasman JM, Zayas MJ, Page RL, Pins GD (2015) Biomimetic scaffolds for regeneration of volumetric muscle loss in skeletal muscle injuries. Acta Biomater 25:2–15 Grieshober JA, Fakunle E, Gambardella RA (2017) Orthobiologics: regulation in different parts of the world. In: Bio-orthopaedics. Springer, Berlin, Heidelberg, pp 47–63 Gupta AK, Hug K, Boggess B, Gavigan M, Toth AP (2013) Massive or 2-tendon rotator cuff tears in active patients with minimal glenohumeral arthritis: clinical and radiographic outcomes of reconstruction using dermal tissue matrix xenograft. Am J Sports Med 41(4):872–879 Henkel J, Woodruff MA, Epari DR, Steck R, Glatt V, Dickinson IC, Choong PF, Schuetz MA, Hutmacher DW (2013) Bone regeneration based on tissue engineering conceptions—a 21st century perspective. Bone Res 1(3):216 Hernigou P, Lachaniette CHF, Delambre J, Zilber S, Duffiet P, Chevallier N, Rouard H (2014) Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study. Int Orthop 38(9):1811–1818 Hogan MV, Kawakami Y, Murawski CD, Fu FH (2015) Tissue engineering of ligaments for reconstructive surgery. Arthroscopy 31(5):971–979 Hollister SJ (2009a) Scaffold design and manufacturing: from concept to clinic. Adv Mater 21(32–33):3330–3342 Hollister SJ (2009b) Scaffold engineering: a bridge to where? Biofabrication 1(1):012001 Hu JC, Athanasiou KA (2006) A self-assembling process in articular cartilage tissue engineering. Tissue Eng 12(4):969–979 Huang BJ, Hu JC, Athanasiou KA (2016) Cell-based tissue engineering strategies used in the clinical repair of articular cartilage. Biomaterials 98:1–22 Huang H, Zhang X, Hu X, Shao Z, Zhu J, Dai L, Man Z, Yuan L, Chen H, Zhou C (2014) A functional biphasic biomaterial homing mesenchymal stem cells for in vivo cartilage regeneration. Biomaterials 35(36):9608–9619 Huey DJ, Hu JC, Athanasiou KA (2012) Unlike bone, cartilage regeneration remains elusive. Science 338(6109):917–921 Hunziker EB, Lippuner K, Keel M, Shintani N (2015) An educational review of cartilage repair: precepts & practice–myths & misconceptions–progress & prospects. Osteoarthr Cartil 23(3):334–350 Iannotti JP, Codsi MJ, Kwon YW, Derwin K, Ciccone J, Brems JJ (2006) Porcine small intestine submucosa augmentation of surgical repair of chronic two-tendon rotator cuff tears: a randomized, controlled trial. JBJS 88(6):1238–1244 Iwasa J, Engebretsen L, Shima Y, Ochi M (2009) Clinical application of scaffolds for cartilage tissue engineering. Knee Surg Sports Traumatol Arthrosc 17(6):561–577 James KS, Cornwell KC, Greenburg AG (2010) TissueMend™. Exp Rev Med Devices 7(1):9–9 Jin G, Yang GH, Kim G (2015) Tissue engineering bioreactor systems for applying physical and electrical stimulations to cells. J Biomed Mater Res B Appl Biomater 103(4):935–948 Karp JM, Teo GSL (2009) Mesenchymal stem cell homing: the devil is in the details. Cell Stem Cell 4(3):206–216 Kawate K, Yajima H, Ohgushi H, Kotobuki N, Sugimoto K, Ohmura T, Kobata Y, Shigematsu K, Kawamura K, Tamai K (2006) Tissue-engineered approach for the treatment of steroid-induced osteonecrosis of the femoral head: transplantation of autologous mesenchymal stem cells cultured with Beta-Tricalcium phosphate ceramics and free vascularized fibula. Artif Organs 30(12):960–962 Knutsen G, Drogset JO, Engebretsen L, Grøntvedt T, Ludvigsen TC, Løken S, Solheim E, Strand T, Johansen O (2016) A randomized multicenter trial comparing autologous chondrocyte implantation with microfracture: long-term follow-up at 14 to 15 years. JBJS 98(16):1332–1339 Ko IK, Lee SJ, Atala A, Yoo JJ (2013) In situ tissue regeneration through host stem cell recruitment. Exp Mol Med 45(11):e57 Kon E, Delcogliano M, Filardo G, Pressato D, Busacca M, Grigolo B, Desando G, Marcacci M (2010) A novel nano-composite multi-layered biomaterial for treatment of osteochondral lesions: technique note and an early stability pilot clinical trial. Injury 41(7):693–701 Kon E, Filardo G, Perdisa F, Venieri G, Marcacci M (2014) Clinical results of multilayered biomaterials for osteochondral regeneration. J Exp Orthop 1(1):10 Kreuz PC, Müller S, Freymann U, Erggelet C, Niemeyer P, Kaps C, Hirschmüller A (2011) Repair of focal cartilage defects with scaffold-assisted autologous chondrocyte grafts: clinical and biomechanical results 48 months after transplantation. Am J Sports Med 39(8):1697–1706 Kreuz PC, Müller S, Ossendorf C, Kaps C, Erggelet C (2009) Treatment of focal degenerative cartilage defects with polymer-based autologous chondrocyte grafts: four-year clinical results. Arthritis Res Ther 11(2):R33 Kwee BJ, Mooney DJ (2017) Biomaterials for skeletal muscle tissue engineering. Curr Opin Biotechnol 47:16–22 Kwon H, Paschos NK, Hu JC, Athanasiou K (2016) Articular cartilage tissue engineering: the role of signaling molecules. Cell Mol Life Sci 73(6):1173–1194 Lee DY, Cho T-J, Kim JA, Lee HR, Yoo WJ, Chung CY, Choi IH (2008) Mobilization of endothelial progenitor cells in fracture healing and distraction osteogenesis. Bone 42(5):932–941 Li Y, Xiao Y, Liu C (2017) The horizon of materiobiology: a perspective on material-guided cell behaviors and tissue engineering. Chem Rev 117(5):4376–4421 Lyman S, Nakamura N, Cole BJ, Erggelet C, Gomoll AH, Jack Farr I (2016) Cartilage-repair innovation at a standstill: methodologic and regulatory pathways to breaking free. JBJS 98(15):e63 Lysaght T, Kerridge IH, Sipp D, Porter G, Capps BJ (2017) Ethical and regulatory challenges with autologous adult stem cells: a comparative review of international regulations. J Bioeth Inq 14(2):261–273 Madry H, Alini M, Stoddart M, Evans C, Miclau T, Steiner S (2014) Barriers and strategies for the clinical translation of advanced orthopaedic tissue engineering protocols. Eur Cell Mater 27:17–21 Madry H, Ochi M, Cucchiarini M, Pape D, Seil R (2015) Large animal models in experimental knee sports surgery: focus on clinical translation. J Exp Orthop 2(1):9 Malhotra A, Pelletier MH, Yu Y, Walsh WR (2013) Can platelet-rich plasma (PRP) improve bone healing? A comparison between the theory and experimental outcomes. Arch Orthop Trauma Surg 133(2):153–165 Marcacci M, Kon E, Moukhachev V, Lavroukov A, Kutepov S, Quarto R, Mastrogiacomo M, Cancedda R (2007) Stem cells associated with macroporous bioceramics for long bone repair: 6-to 7-year outcome of a pilot clinical study. Tissue Eng 13(5):947–955 Martin I, Miot S, Barbero A, Jakob M, Wendt D (2007) Osteochondral tissue engineering. J Biomech 40(4):750–765 Martin I, Smith T, Wendt D (2009) Bioreactor-based roadmap for the translation of tissue engineering strategies into clinical products. Trends Biotechnol 27(9):495–502 Mase VJ, Hsu JR, Wolf SE, Wenke JC, Baer DG, Owens J, Badylak SF, Walters TJ (2010) Clinical application of an acellular biologic scaffold for surgical repair of a large, traumatic quadriceps femoris muscle defect. Orthopedics 33(7):511 McCarron JA, Milks RA, Chen X, Iannotti JP, Derwin KA (2010) Improved time-zero biomechanical properties using poly-L-lactic acid graft augmentation in a cadaveric rotator cuff repair model. J Shoulder Elb Surg 19(5):688–696 McCormick F, Cole BJ, Nwachukwu B, Harris JD, Adkisson HD IV, Farr J (2013) Treatment of focal cartilage defects with a juvenile allogeneic 3-dimensional articular cartilage graft. Operative Techniques in Sports Med 21(2):95–99 McCullen SD, Chow AG, Stevens MM (2011) In vivo tissue engineering of musculoskeletal tissues. Curr Opin Biotechnol 22(5):715–720 Melton JT, Wilson AJ, Chapman-Sheath P, Cossey AJ (2010) TruFit CB® bone plug: chondral repair, scaffold design, surgical technique and early experiences. Exp Rev Med Devices 7(3):333–341 Mengsteab PY, Nair LS, Laurencin CT (2016) The past, present and future of ligament regenerative engineering. Regen Med 11(8):871–881 Metcalf KB, Mandelbaum BR, McIlwraith CW (2013) Application of platelet-rich plasma to disorders of the knee joint. Cartilage 4(4):295–312 Meyer U, Wiesmann HP (2006) Cells/surface interactions. In: Bone and cartilage engineering. Springer Berlin Heidelberg, Berlin, Heidelberg, pp 131–148 Mollon B, Kandel R, Chahal J, Theodoropoulos J (2013) The clinical status of cartilage tissue regeneration in humans. Osteoarthr Cartil 21(12):1824–1833 Monllau JC, Gelber PE, Abat F, Pelfort X, Abad R, Hinarejos P, Tey M (2011) Outcome after partial medial meniscus substitution with the collagen meniscal implant at a minimum of 10 years' follow-up. Arthroscopy 27(7):933–943 Moran CJ, Ramesh A, Brama PA, O’Byrne JM, O’Brien FJ, Levingstone TJ (2016) The benefits and limitations of animal models for translational research in cartilage repair. J Exp Orthop 3(1):1 Mundi R, Bedi A, Chow L, Crouch S, Simunovic N, Sibilsky Enselman E, Ayeni OR (2016) Cartilage restoration of the knee: a systematic review and meta-analysis of level 1 studies. Am J Sports Med 44(7):1888–1895 Musahl V, Murphy CI, Pfeiffer TP, Burnham JM, Gasbarro GV (2017) Current state for clinical use of stem cells and platelet-rich plasma. In: Gobbi A, Espregueira-Mendes J, Lane JG, Karahan M (eds) Bio-orthopaedics: a new approach. Springer Berlin Heidelberg, Berlin, Heidelberg, pp 105–124 Nada A, Debnath U, Robinson D, Jordan C (2010) Treatment of massive rotator-cuff tears with a polyester ligament (Dacron) augmentation. Bone Joint J 92(10):1397–1402 Naim S, Gougoulias N, Griffiths D (2011) Patellar tendon reconstruction using LARS ligament: surgical technique and case report. Strategies Trauma Limb Reconstruction 6(1):39–41 Nakasa T, Adachi N, Ochi M (2017) Clinical Orthobiological approach to acute cartilage injury: pros and cons. In: Gobbi A, Espregueira-Mendes J, Lane JG, Karahan M (eds) Bio-orthopaedics: a new approach. Springer Berlin Heidelberg, Berlin, Heidelberg, pp 503–515 Narayanan G, Bhattacharjee M, Nair LS, Laurencin CT (2017) Musculoskeletal tissue regeneration: the role of the stem cells. Regenerative Eng Translat Med 3(3):133–165 Nehrer S, Chiari C, Domayer S, Barkay H, Yayon A (2008) Results of chondrocyte implantation with a fibrin-hyaluronan matrix: a preliminary study. Clin Orthop Relat Res 466(8):1849–1855 Niethammer TR, Holzgruber M, Gülecyüz MF, Weber P, Pietschmann MF, Müller PE (2017) Matrix based autologous chondrocyte implantation in children and adolescents: a match paired analysis in a follow-up over three years post-operation. Int Orthop 41(2):343–350 Niethammer TR, Pietschmann MF, Horng A, Roßbach BP, Ficklscherer A, Jansson V, Müller PE (2014) Graft hypertrophy of matrix-based autologous chondrocyte implantation: a two-year follow-up study of NOVOCART 3D implantation in the knee. Knee Surg Sports Traumatol Arthrosc 22(6):1329–1336 Nourissat G, Mainard D, Kelberine F, SFA FAS (2013) Current concept for the use of PRP in arthroscopic surgery. Orthop Traumatol Surg Res 99(8):S407–S410 Oner T, Cengiz I, Pitikakis M, Cesario L, Parascandolo P, Vosilla L, Viano G, Oliveira J, Reis R, Silva-Correia J (2017) 3D segmentation of intervertebral discs: from concept to the fabrication of patient-specific scaffolds. J 3D Printing Med 1(2):91–101 Oryan A, Alidadi S, Moshiri A, Maffulli N (2014) Bone regenerative medicine: classic options, novel strategies, and future directions. J Orthop Surg Res 9(1):18 Ossendorf C, Kaps C, Kreuz PC, Burmester GR, Sittinger M, Erggelet C (2007) Treatment of posttraumatic and focal osteoarthritic cartilage defects of the knee with autologous polymer-based three-dimensional chondrocyte grafts: 2-year clinical results. Arthritis Res Ther 9(2):R41 Pennesi G, Scaglione S, Giannoni P, Quarto R (2011) Regulatory influence of scaffolds on cell behavior: how cells decode biomaterials. Curr Pharm Biotechnol 12(2):151–159 Pereira H, Cengiz IF, Silva-Correia J, Oliveira JM, Reis RL, Espregueira-Mendes J (2016a) The role of arthroscopy in the treatment of degenerative meniscus tear. In: Arthroscopy. Springer, Berlin, Heidelberg, pp 107–117 Pereira H, Cengiz IF, Silva-Correia J, Ripoll PL, Varatojo R, Oliveira JM, Reis RL, Espregueira-Mendes J (2016b) Meniscal repair: indications, techniques, and outcome. In: Arthroscopy. Springer, Berlin, Heidelberg, pp 125–142 Petri M, Broese M, Simon A, Liodakis E, Ettinger M, Guenther D, Zeichen J, Krettek C, Jagodzinski M, Haasper C (2013) CaReS®(MACT) versus microfracture in treating symptomatic patellofemoral cartilage defects: a retrospective matched-pair analysis. J Orthop Sci 18(1):38–44 Petri M, Greenspoon JA, Bhatia S, Millett PJ (2015) Patch-augmented latissimus dorsi transfer and open reduction–internal fixation of unstable Os acromiale for irreparable massive posterosuperior rotator cuff tear. Arthroscopy Techniques 4(5):e487–e492 Petriccioli D, Bertone C, Marchi G, Mujahed I (2013) Open repair of isolated traumatic subscapularis tendon tears with a synthetic soft tissue reinforcement. Musculoskelet Surg 97(1):63–68 Piuzzi NS, Chughtai M, Khlopas A, Harwin SF, Miniaci A, Mont MA, Muschler GF (2017) Platelet-rich plasma for the treatment of knee osteoarthritis: a review. J Knee Surg 30(07):627–633 Proctor CS (2014) Long-term successful arthroscopic repair of large and massive rotator cuff tears with a functional and degradable reinforcement device. J Shoulder Elb Surg 23(10):1508–1513 Qazi TH, Mooney DJ, Pumberger M, Geissler S, Duda GN (2015) Biomaterials based strategies for skeletal muscle tissue engineering: existing technologies and future trends. Biomaterials 53:502–521 Rao RT, Browe DP, Lowe CJ, Freeman JW (2016) An overview of recent patents on musculoskeletal interface tissue engineering. Connect Tissue Res 57(1):53–67 Ravichandran A, Liu Y, Teoh SH (2017) Bioreactor design towards generation of relevant engineered tissues: focus on clinical translation. J Tissue Eng Regen Med. 12(1):e7-e22 Ricchetti ET, Aurora A, Iannotti JP, Derwin KA (2012) Scaffold devices for rotator cuff repair. J Shoulder Elb Surg 21(2):251–265 Roffi A, Krishnakumar GS, Gostynska N, Kon E, Candrian C, Filardo G (2017) The role of three-dimensional scaffolds in treating long bone defects: evidence from preclinical and clinical literature—a systematic review. Biomed Res Int 2017:8074178 Rotini R, Marinelli A, Guerra E, Bettelli G, Castagna A, Fini M, Bondioli E, Busacca M (2011) Human dermal matrix scaffold augmentation for large and massive rotator cuff repairs: preliminary clinical and MRI results at 1-year follow-up. Musculoskelet Surg 95(1):13 Salter E, Goh B, Hung B, Hutton D, Ghone N, Grayson WL (2011) Bone tissue engineering bioreactors: a role in the clinic? Tissue Eng B Rev 18(1):62–75 Saris D, Price A, Widuchowski W, Bertrand-Marchand M, Caron J, Drogset JO, Emans P, Podskubka A, Tsuchida A, Kili S (2014) Matrix-applied characterized autologous cultured chondrocytes versus microfracture: two-year follow-up of a prospective randomized trial. Am J Sports Med 42(6):1384–1394 Schneider U, Rackwitz L, Andereya S, Siebenlist S, Fensky F, Reichert J, Löer I, Barthel T, Rudert M, Nöth U (2011) A prospective multicenter study on the outcome of type I collagen hydrogel–based autologous chondrocyte implantation (CaReS) for the repair of articular cartilage defects in the knee. Am J Sports Med 39(12):2558–2565 Selmi TAS, Verdonk P, Chambat P, Dubrana F, Potel J-F, Barnouin L, Neyret P (2008) Autologous chondrocyte implantation in a novel alginate-agarose hydrogel: outcome at two years. Bone Joint J 90(5):597–604 Shea KP, McCarthy MB, Ledgard F, Arciero C, Chowaniec D, Mazzocca AD (2010) Human tendon cell response to 7 commercially available extracellular matrix materials: an in vitro study. Arthroscopy 26(9):1181–1188 Shen W, Chen X, Chen J, Yin Z, Heng BC, Chen W, Ouyang H-W (2010) The effect of incorporation of exogenous stromal cell-derived factor-1 alpha within a knitted silk-collagen sponge scaffold on tendon regeneration. Biomaterials 31(28):7239–7249 Sheth U, Simunovic N, Klein G, Fu F, Einhorn TA, Schemitsch E, Ayeni OR, Bhandari M (2012) Efficacy of autologous platelet-rich plasma use for orthopaedic indications: a meta-analysis. J Bone Joint Surg 94(4):298–307 Shive MS, Hoemann CD, Restrepo A, Hurtig MB, Duval N, Ranger P, Stanish W, Buschmann MD (2006) BST-CarGel: in situ chondroinduction for cartilage repair. Oper Tech Orthop 16(4):271–278 Sicari BM, Londono R, Badylak SF (2015) Strategies for skeletal muscle tissue engineering: seed vs. soil. J Mater Chem B 3(40):7881–7895 Sicari BM, Rubin JP, Dearth CL, Wolf MT, Ambrosio F, Boninger M, Turner NJ, Weber DJ, Simpson TW, Wyse A (2014) An acellular biologic scaffold promotes skeletal muscle formation in mice and humans with volumetric muscle loss. Sci Transl Med 6(234):234ra258–234ra258 Siebold R, Suezer F, Schmitt B, Trattnig S, Essig M (2018) Good clinical and MRI outcome after arthroscopic autologous chondrocyte implantation for cartilage repair in the knee. Knee Surg Sports Traumatol Arthrosc 26(3):831–839 Smith R, Carr A, Dakin S, Snelling S, Yapp C, Hakimi O (2016) The response of tenocytes to commercial scaffolds used for rotator cuff repair. eCells Mater J 30:107–118 Smith RD, Zargar N, Brown CP, Nagra NS, Dakin SG, Snelling SJ, Hakimi O, Carr A (2017) Characterizing the macro and micro mechanical properties of scaffolds for rotator cuff repair. J Shoulder Elb Surg 26(11):2038–2046 Soler JA, Gidwani S, Curtis MJ (2007) Early complications from the use of porcine dermal collagen implants (Permacol™) as bridging constructs in the repair of massive rotator cuff tears. A report of 4 cases. Acta Orthop Belg 73(4):432 Song L, Olsen RE, Spalazzi JP, Davisson T (2010) Biomechanical evaluation of acellular collagen matrix augmented Achilles tendon repair in sheep. J Foot Ankle Surg 49(5):438–441 Sotome S, Ae K, Okawa A, Ishizuki M, Morioka H, Matsumoto S, Nakamura T, Abe S, Beppu Y, Shinomiya K (2016) Efficacy and safety of porous hydroxyapatite/type 1 collagen composite implantation for bone regeneration: a randomized controlled study. J Orthop Sci 21(3):373–380 Stevens MM, George JH (2005) Exploring and engineering the cell surface interface. Science 310(5751):1135–1138 Tellado SF, Balmayor ER, Van Griensven M (2015) Strategies to engineer tendon/ligament-to-bone interface: biomaterials, cells and growth factors. Adv Drug Deliv Rev 94:126–140 Utku B, Dönmez G, Büyükdoğan K, Karanfil Y, Tolevska RD, Korkusuz F, Doral MN (2015) Platelet-rich plasma: from laboratory to the clinic. In: Sports injuries: prevention, diagnosis, treatment and rehabilitation, pp 3223–3250 Verdonk P, Beaufils P, Bellemans J, Djian P, Heinrichs EL, Huysse W, Laprell H, Siebold R, Verdonk R (2012) Successful treatment of painful irreparable partial meniscal defects with a polyurethane scaffold: two-year safety and clinical outcomes. Am J Sports Med 40(4):844–853 Vilela C, Correia C, Oliveira JM, Sousa RA, Mendes JE, Reis RL (2015) Cartilage repair using hydrogels: a critical review of in vivo experimental designs. ACS Biomater Sci Eng 1(9):726–739 Wakitani S, Nawata M, Tensho K, Okabe T, Machida H, Ohgushi H (2007) Repair of articular cartilage defects in the patello-femoral joint with autologous bone marrow mesenchymal cell transplantation: three case reports involving nine defects in five knees. J Tissue Eng Regen Med 1(1):74–79 Walden G, Liao X, Donell S, Raxworthy MJ, Riley GP, Saeed A (2017) A clinical, biological, and biomaterials perspective into tendon injuries and regeneration. Tissue Eng B Rev 23(1):44–58 Walton JR, Bowman NK, Khatib Y, Linklater J, Murrell GA (2007) Restore orthobiologic implant: not recommended for augmentation of rotator cuff repairs. JBJS 89(4):786–791 Wong I, Burns J, Snyder S (2010) Arthroscopic GraftJacket repair of rotator cuff tears. J Shoulder Elb Surg 19(2):104–109 Xu H, Sandor M, Qi S, Lombardi J, Connor J, McQuillan DJ, Iannotti JP (2012) Implantation of a porcine acellular dermal graft in a primate model of rotator cuff repair. J Shoulder Elb Surg 21(5):580–588 Yan L, Oliveira JM, Oliveira AL, Reis RL (2015) Current concepts and challenges in osteochondral tissue engineering and regenerative medicine. ACS Biomater Sci Eng 1(4):183–200 Youngstrom DW, Barrett JG (2015) Engineering Tendon: Scaffolds, Bioreactors, and Models of Regeneration,” Stem Cells International, vol. 2016, Article ID 3919030, 11 pages, 2016. https://doi.org/10.1155/2016/3919030. Zaffagnini S, Grassi A, Marcheggiani Muccioli GM, Bonanzinga T, Nitri M, Raggi F, Ravazzolo G, Marcacci M (2015) MRI evaluation of a collagen meniscus implant: a systematic review. Knee Surg Sports Traumatol Arthrosc 23(11):3228–3237 Zaffagnini S, Marcheggiani Muccioli GM, Grassi A, Bonanzinga T, Filardo G, Canales Passalacqua A, Marcacci M (2011) Arthroscopic lateral collagen meniscus implant in a professional soccer player. Knee Surg Sports Traumatol Arthrosc 19(10):1740–1743 Zajac AL, Discher DE (2008) Cell differentiation through tissue elasticity-coupled, myosin-driven remodeling. Curr Opin Cell Biol 20(6):609–615 Zak L, Albrecht C, Wondrasch B, Widhalm H, Vekszler G, Trattnig S, Marlovits S, Aldrian S (2014) Results 2 years after matrix-associated autologous chondrocyte transplantation using the Novocart 3D scaffold: an analysis of clinical and radiological data. Am J Sports Med 42(7):1618–1627 Zeifang F, Oberle D, Nierhoff C, Richter W, Moradi B, Schmitt H (2010) Autologous chondrocyte implantation using the original periosteum-cover technique versus matrix-associated autologous chondrocyte implantation: a randomized clinical trial. Am J Sports Med 38(5):924–933 Zheng MH, Chen J, Kirilak Y, Willers C, Xu J, Wood D (2005) Porcine small intestine submucosa (SIS) is not an acellular collagenous matrix and contains porcine DNA: possible implications in human implantation. J Biomed Mater Res B Appl Biomater 73(1):61–67