Organogenesis in a dish: Modeling development and disease using organoid technologies

American Association for the Advancement of Science (AAAS) - Tập 345 Số 6194 - 2014
Madeline A. Lancaster1, Juergen A. Knoblich1
1IMBA-Institute of Molecular Biotechnology of the Austrian Academy of Science Vienna 1030, Austria.

Tóm tắt

The making of bodies part by part Mention of organoids—organlike structure growing in a Petri dish—might conjure up images of science fiction. However, the generation of organoids is very real, as is the increased understanding of organ form and function that comes from studying them. Lancaster and Knoblich review organoids as structures that include more than one cell type of an organ that exhibit structural and functional features of the natural counterpart. Knowledge of normal organ developmental pathways guides the formation of these structures. Organoids show great promise for modeling human development and disease and for biomedical research and regenerative medicine. Science , this issue 10.1126/science.1247125

Từ khóa


Tài liệu tham khảo

R. Lanza J. Gearhart B. Hogan D. Melton R. Pedersen Eds. Essentials of Stem Cell Biology (Elsevier San Diego CA ed. 2 2009).

10.1016/0046-8177(94)90173-2

10.1111/j.1432-0436.1987.tb00183.x

10.1681/ASN.2012050505

10.3109/10409238909086396

S. F. Gilbert Ed. Developmental Biology (Sinauer Associates Sunderland MA ed. 6 2000).

10.1038/nrg2902

10.1038/nrn1702

10.1073/pnas.46.9.1177

10.1016/0014-4827(61)90122-7

L. Wolpert Ed. Principles of Development (Oxford University Press Oxford ed. 3 2007).

M. S. Steinberg in Cellular Membranes in Development M. Locke Ed. (Academic Press New York 1964) pp. 321–366.

10.1242/dev.122.5.1611

10.1242/dev.110.1.97

10.1016/0896-6273(90)90108-R

10.1146/annurev.cellbio.042308.113259

10.1016/j.neuron.2005.09.030

10.1016/S0166-2236(00)02036-1

10.1016/0304-3940(86)90019-4

10.1098/rspb.1997.0179

10.1007/s100249900089

10.1002/bdra.10133

10.1038/nrm3190

Weitzer G., Embryonic stem cell-derived embryoid bodies: An in vitro model of eutherian pregastrulation development and early gastrulation. Handbook Exp. Pharmacol. 2006, 21–51 (2006).

10.1016/0092-8674(91)90115-F

10.1098/rstb.1998.0250

10.1073/pnas.84.1.136

10.1038/nature12517

10.1016/j.stem.2013.11.010

10.1016/S0070-2153(10)90004-5

10.1016/j.mod.2005.10.001

10.1242/dev.001230

10.1038/nature09691

10.1038/nature07935

10.1038/nm.2695

10.1016/j.stem.2009.11.013

10.1016/j.cell.2013.09.008

10.1038/srep03224

10.1038/nrg837

10.1038/nature11826

10.1038/nature12271

10.3389/fnmol.2011.00030

10.1146/annurev-cellbio-092910-154026

10.1016/j.conb.2012.04.003

10.1508/cytologia.31.89

10.1038/nrn2938

10.1126/science.1553558

10.1101/gad.1616208

10.1038/nbt1201-1129

10.1038/nature07287

10.1038/488444a

10.1038/nn1402

10.1038/nbt1310

10.1016/j.stem.2008.09.002

10.1073/pnas.1315710110

10.1523/JNEUROSCI.5128-10.2011

10.1016/j.ydbio.2005.11.010

10.1038/nn.2638

10.1073/pnas.0803078105

10.1101/cshperspect.a008391

Stefanelli A., Zacchei A. M., Ceccherini V., Retinal reconstitution in vitro after disaggregation of embryonic chicken eyes. Acta Embryol. Morphol. Exp. 4, 47–55 (1961).

10.1002/jcp.1030600407

10.1016/S0012-1606(03)00320-8

10.1038/nature09941

10.1016/j.stem.2012.05.009

10.1101/cshperspect.a008300

10.1038/ncb2904

10.1038/ncb2872

10.1038/ncb2894

10.1038/nature11525

10.1016/j.cell.2013.12.039

10.1242/dev.096628

10.1038/nature10637

10.1038/nature12298

F. Prop G. J. Wiepjes in Tissue Culture: Methods and Applications P. F. Kruse Jr. and M. K. Patterson Jr. Eds. (Academic Press New York 1973) pp. 21–24.

10.1126/science.140.3573.1273

Moscona A., Moscona H., The dissociation and aggregation of cells from organ rudiments of the early chick embryo. J. Anat. 86, 287–301 (1952).12980879

10.1007/978-1-60327-009-0_13

10.1038/nature09637

10.1073/pnas.1201652109

10.1128/mBio.00159-12

10.1128/IAI.01131-12

10.1073/pnas.0915135107

10.1073/pnas.1221926110

10.1172/JCI71471

10.1038/nm.3201

10.1016/j.copbio.2013.08.015

10.1242/dev.092270

10.1016/j.stem.2013.09.015

10.1007/BF00335651

10.1016/S0014-4827(66)80115-5

10.1016/j.stem.2012.01.019

10.1016/j.stem.2012.01.018

10.1073/pnas.58.6.2227

10.1126/science.1058866

10.1038/nbt1259

10.3727/000000004783984016

10.1111/j.1440-169X.1993.00033.x

10.1016/0012-1606(83)90209-9

10.1016/j.diff.2010.09.182

D. A. Fischman A. A. Moscona in Cardiac Hypertrophy N. K. Alpert Ed. (Academic Press New York 1971) pp. 125–139.

10.1084/jem.133.4.677

10.1161/01.RES.0000027865.61704.32

10.1073/pnas.0908381106

10.1126/scitranslmed.3003541

van der Schaft D. W. J., van Spreeuwel A. C., Boonen K. J., Langelaan M. L., Bouten C. V., Baaijens F. P., Engineering skeletal muscle tissues from murine myoblast progenitor cells and application of electrical stimulation. J. Vis. Exp. 2013, e4267 (2013). 23542531

10.1089/107632700300003323

10.1089/ten.2004.10.1518

10.1038/79439

10.1016/j.bbrc.2011.12.071

10.1038/ncomms2378

10.1073/pnas.0500010102

10.1073/pnas.0601990103

Sobel H., The behaviour in vitro of dissociated embryonic pituitary tissue. J. Embryol. Exp. Morphol. 6, 518–526 (1958).13575665

10.1038/nmeth1015

10.1016/0012-1606(68)90088-2

10.1073/pnas.2334503100

10.1016/S0960-9822(03)00296-3

10.1126/science.25.649.912

Holtfreter J., Experimental studies on the development of the pronephros. Rev. Can. Biol. 3, 220–250 (1944).

10.1002/1097-0142(196109/10)14:5<1017::AID-CNCR2820140516>3.0.CO;2-P

10.1530/jrf.0.0620625

10.1073/pnas.78.12.7634

10.1016/0167-4889(87)90200-X

10.1126/science.282.5391.1145

Thông tin
Thông tin xuất bản

American Association for the Advancement of Science (AAAS)

Tập 345 Số 6194

Thông tin tác giả