Orexins: a role in medullary sympathetic outflow

Regulatory Peptides - Tập 96 - Trang 65-70 - 2000
Nae J. Dun1, Siok Le Dun,1, Chiung-Tong Chen1, Ling Ling Hwang1, Ernest H. Kwok1, Jaw-Kang Chang2
1Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, P.O. Box 70577, Johnson City, TN 37614 USA
2Phoenix Pharmaceuticals, Inc. Mountain View, CA 94043, USA

Tài liệu tham khảo

Sakurai, 1998, Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior, Cell, 92, 573, 10.1016/S0092-8674(00)80949-6 De Lecea, 1998, The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity, Proc Natl Acad Sci USA, 95, 322, 10.1073/pnas.95.1.322 Chemelli, 1999, Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation, Cell, 98, 437, 10.1016/S0092-8674(00)81973-X Lin, 1999, The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene, Cell, 98, 365, 10.1016/S0092-8674(00)81965-0 Chen, 1999, Orexin A-like immunoreactivity in the rat brain, Neurosci Lett, 260, 161, 10.1016/S0304-3940(98)00977-X Peyron, 1998, Neurons containing hypocretin (orexin) project to multiple neuronal systems, J Neurosci, 18, 9996, 10.1523/JNEUROSCI.18-23-09996.1998 Date, 1999, Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems, Proc Natl Acad Sci USA, 96, 748, 10.1073/pnas.96.2.748 Van den Pol, 1999, Hypothalamic hypocretin (orexin): robust innervation of the spinal cord, J Neurosci, 19, 3171, 10.1523/JNEUROSCI.19-08-03171.1999 Cutler, 1999, Differential distribution of orexin-A and orexin-B immunoreactivity in the rat brain and spinal cord, Peptides, 20, 1455, 10.1016/S0196-9781(99)00157-6 Harrison, 1999, Hypothalamic orexin A-immunoreactive neurons project to the rat dorsal medulla, Neurosci Lett, 273, 17, 10.1016/S0304-3940(99)00611-4 Ross, 1984, Rostral ventrolateral medulla: selective projections to the thoracic autonomic cell column from the region containing Cl adrenaline neurons, J Comp Neurol, 228, 168, 10.1002/cne.902280204 Chen, 2000, Pressor effects of orexins injected intracisternally and to rostral ventrolateral medulla of anesthetized rat, Am J Physiol, 278, R692 Samson, 1999, Cardiovascular regulatory actions of the hypocretins in brain, Brain Res, 831, 248, 10.1016/S0006-8993(99)01457-2 Shirasaka, 1999, Sympathetic and cardiovascular actions of orexins in conscious rats, Am J Physiol, 46, R1780 Lin, 1998, GABA- and glycine-mediated inhibitory postsynaptic potentials in neonatal rat rostral ventrolateral medulla neurons in vitro, Neurosci, 82, 429, 10.1016/S0306-4522(97)00294-7 Hwang, 1999, 5-HT modulates multiple conductances in immature rat rostral ventrolateral medulla neurones in vitro, J Physiol (Lond), 517, 217, 10.1111/j.1469-7793.1999.0217z.x Hagan, 1999, Orexin A activates locus coeruleus cell firing and increases arousal in the rat, Proc Nail Acad Sci USA, 96, 10911, 10.1073/pnas.96.19.10911 Van den Pol, 1998, Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalalmic peptide, hypocretin/orexin, J Neurosci, 18, 7962, 10.1523/JNEUROSCI.18-19-07962.1998 Smart, 1999, Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell-line using FLIPR, Br J Pharmacol, 128, 1, 10.1038/sj.bjp.0702780 Dun, 1993, Hemorrhage induces Fos immunoreactivity in rat medullary catecholaminergic neurons, Brain Res, 608, 223, 10.1016/0006-8993(93)91462-2 Dun, 1995, c-Fos expression as a marker of central cardiovascular neurons, Biol Signals, 4, 117, 10.1159/000109431 Bemardis, 1996, The lateral hypothalamic area revisited: ingestive behavior, Neurosci Biobehav Rev, 20, 189, 10.1016/0149-7634(95)00015-1 Trivedi, 1998, Distribution of orexin receptor mRNA in the rat brain, FEBB Lett, 438, 71, 10.1016/S0014-5793(98)01266-6 DeLecea, 1999, The hypocretins/orexins: novel hypothalamic neuropeptides involved in different physiological systems, Cell Mol Life Sci, 56, 473, 10.1007/s000180050446 Sakurai, 1999, Orexins and orexin receptors: implication in feeding behavior, Reg Pept, 85, 25, 10.1016/S0167-0115(99)00076-2 Rumantir, 1999, Neural mechanisms in human obesity-related hypertension, J Hyper, 17, 1125, 10.1097/00004872-199917080-00012