Oral microbiome homogeneity across diverse human groups from southern Africa: first results from southwestern Angola and Zimbabwe

BMC Microbiology - Tập 23 Số 1
Vı́tor Araújo1,2,3, Anne-Maria Fehn1,3, Admire Phiri4, Jeffrey Wills5, Jorge Rocha1,2,3, Magdalena Gayà-Vidal1,3
1Centro de Investigação em Biodiversidade e Recursos Genéticos, CIBIO, InBIO Laboratório Associado, Universidade do Porto, Vairão, Portugal
2Departamento de Biologia, Faculdade de Ciências, Universidade do Porto, Porto, Portugal
3Program in Genomics, Biodiversity and Land Planning, CIBIO, BIOPOLIS, Vairão, Portugal
4Department of Linguistics and Language Practice, University of Free State, Bloemfontein, South Africa
5University of Zimbabwe, Harare, Zimbabwe

Tóm tắt

Abstract Background While the human oral microbiome is known to play an important role in systemic health, its average composition and diversity patterns are still poorly understood. To gain better insights into the general composition of the microbiome on a global scale, the characterization of microbiomes from a broad range of populations, including non-industrialized societies, is needed. Here, we used the portion of non-human reads obtained through an expanded exome capture sequencing approach to characterize the saliva microbiomes of 52 individuals from eight ethnolinguistically diverse southern African populations from Angola (Kuvale, Kwepe, Himba, Tjimba, Kwisi, Twa, !Xun) and Zimbabwe (Tshwa), including foragers, food-producers, and peripatetic groups (low-status communities who provide services to their dominant neighbors). Results Our results indicate that neither host genetics nor livelihood seem to influence the oral microbiome profile, with Neisseria, Streptococcus, Prevotella, Rothia, and Porphyromonas being the five most frequent genera in southern African groups, in line with what has been shown for other human populations. However, we found that some Tshwa and Twa individuals display an enrichment of pathogenic genera from the Enterobacteriaceae family (i.e. Enterobacter, Citrobacter, Salmonella) of the Proteobacteria phylum, probably reflecting deficient sanitation and poor health conditions associated with social marginalization. Conclusions Taken together, our results suggest that socio-economic status, rather than ethnolinguistic affiliation or subsistence mode, is a key factor in shaping the salivary microbial profiles of human populations in southern Africa.

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BMC Microbiology

Tập 23 Số 1

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