Oral Disease in Relation to Future Risk of Dementia and Cognitive Decline: Prospective Cohort Study Based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (Advance) Trial

European Psychiatry - Tập 28 Số 1 - Trang 49-52 - 2013
G. David Batty1,2,3,4, Qing Li4, Rachel Huxley4, Sophia Zoungas5,4, Beth A. Taylor6, Bruce Neal4, Bastiaan E. de Galan7,4, Mark Woodward8,4, Stephen Harrap9, Stephen Colagiuri10, Anushka Patel4, John Chalmers4
1Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
2Department of Epidemiology and Public Health, University College of London, Torrington Place, London, UK
3Medical Research Council, Social and Public Health Sciences Unit, Glasgow, UK
4The George Institute for International Health, University of Sydney, Sydney, Australia
5School of Public Health, Monash University, Melbourne, Australia
6Department of Oral Biology, University of Oslo, Oslo, Norway
7Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
8Mount Sinai School of Medicine, New York, United States
9Department of Physiology, University of Melbourne, Melbourne, Australia
10Institute of Obesity, Nutrition and Exercise, University of Sydney, Sydney, Australia

Tóm tắt

AbstractObjective

Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes.

Methods

A total of 11,140 men and women aged 55–88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up.

Results

Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95% confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes.

Conclusions

Tooth loss was associated with an increased risk of both dementia and cognitive decline.

Từ khóa


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European Psychiatry

Tập 28 Số 1

49-52

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