Optical imaging for the detection of cervical cancers in vivo

R. Drezek1, M. Follen2, R. Richards-Kortum3
1Bioengineering Department, Rice University, Houston, TX, USA
2Biomedical Engineering Center, M.D. Anderson Cancer Center, Houston, TX, USA
3Biomedical Engineering Department, University of Texas, Austin, Austin, TX, USA

Tóm tắt

The objective of our research is the development of fast, noninvasive automated optical technologies for the detection of the molecular-specific signatures of cervical precancers. Potential technologies are evaluated using a five-part paradigm including biological plausibility, technical feasibility, intermediate outcomes, patient acceptance, and societal outcomes. Results of ongoing clinical trials of fluorescence and reflectance spectroscopy will be discussed. In addition, the biological basis of each technology is discussed. Because the biologic basis of the technologies differ, a combination of more than one optical approach may provide more accurate assessment of tissue physiological state than would be possible using any one technique alone.

Từ khóa

#Optical imaging #Cancer detection #Cervical cancer #In vivo #Biomedical optical imaging #Clinical trials #Fluorescence #Reflectivity #Spectroscopy #Biological tissues

Tài liệu tham khảo

10.1002/lsm.1900170403 10.1016/S1011-1344(96)00008-5 10.1364/AO.35.005211 zuclich, 1994, Nie Lasers in the Life Sciences, 6, 39 10.1366/0003702991946695 ramanujam, 1996, Spectroscopic Diagnosis of Cervical Intraepithelial Neoplasia (CIN), In Vivo Using Laser Induced Fluorescence Spectra at Multiple Excitation Wavelengths Lasers in Surgery and Medicine, 19, 63 10.1002/(SICI)1096-9101(1996)19:1<46::AID-LSM7>3.0.CO;2-Q 10.1002/(SICI)1096-9101(1999)24:1<29::AID-LSM6>3.3.CO;2-8 10.1111/j.1751-1097.1996.tb03130.x 10.1002/(SICI)1096-9101(1997)21:2<166::AID-LSM8>3.0.CO;2-O 10.1002/lsm.1900120111 10.1073/pnas.91.21.10193 10.1002/lsm.1900130609 tromberg, 1997, Detection of Cervical Pre-Cancer using Reflectance Spectroscopy Talk Office of Women's Health Symposium on Biomedical Optical Diagnostics and Imaging