Opposite effects of centrally administered neuropeptide Y (NPY) on locomotor activity of spontaneously hypertensive (SH) and normal rats
Tóm tắt
Centrally administered neuropeptide Y has been shown to produce sedation manifested by a suppression of locomotor activity and a synchronizing effect on the EEG pattern in normal rats. It has been suggested that this sedative effect of NPY is largely due to a facilitation of the α2‐adrenergic transmission line. In the spontaneously hypertensive (SH) rat, the NPY‐induced up‐regulation of α2‐adrenoceptors observed in normal rats is absent, and NPY produces a desynchronization of the EEG. In the present study, we have therefore examined the effects of NPY on locomotor activity of SH rats and of inbred controls of the Wistar‐Kyoto (WKy) strain, in both morning and evening sessions. In morning sessions, NPY (0.2–5.0 nmol intracerebroventricularly, i. c.v.) increased locomotor activity of SH rats in a dosc‐related manner. WKy rats were largelj inactive
Từ khóa
Tài liệu tham khảo
Drew G.M., 1979, Alpha‐2‐adrenoceptors mediate clonidine‐induced sedation in the rat, Br J Pharmacol, 67, 133, 10.1111/j.1476-5381.1979.tb16116.x
Heilig M. Söderpalm B. Engel J.A.&Widerlöv E.1989.Centrally administered neuropeptide Y (NPY) produces anxiolytic‐like effects in animal anxiety models.Psychopharmacology(In press).