Online study partner‐reported cognitive decline in the Brain Health Registry

Alzheimer's and Dementia: Translational Research and Clinical Interventions - Tập 4 - Trang 565-574 - 2018
Rachel L. Nosheny1,2, Monica R. Camacho2, Philip S. Insel2,3, Derek Flenniken2, Juliet Fockler2, Diana Truran2, Shannon Finley2, Aaron Ulbricht2, Paul Maruff4, Kristine Yaffe1,2, R. Scott Mackin1,2, Michael W. Weiner1,2,3
1UCSF Department of Psychiatry, San Francisco, CA, USA
2San Francisco Veteran's Administration Medical Center, San Francisco, CA, USA
3UCSF Department of Radiology and Biomedical Imaging, San Francisco, CA, USA
4Cogstate Ltd., Melbourne, Australia

Tóm tắt

AbstractIntroductionMethods for efficiently identifying cognitive decline and Alzheimer's disease (AD) are a critical unmet need. The goal of this work was to validate novel online study partner (SP)‐reported outcomes to identify cognitive decline in older adults.MethodsIn older adults enrolled in the Brain Health Registry, we analyzed associations between SP‐reported cognitive decline, measured by the Everyday Cognition Scale, and either (1) participant cognition, assessed by Cogstate Brief Battery or (2) participant‐reported diagnosis of mild cognitive impairment or AD.ResultsWe found strong associations between SP‐reported Everyday Cognition Scale and both Cogstate scores and participant diagnosis. The associations were cognitive domain specific, dependant on participant diagnosis, and were stronger in spouse dyads and those who knew each other longer.DiscussionCollecting SP‐reported data online from a large cohort is feasible. Results support the construct validity of our approach, which has the potential to facilitate clinical AD and aging research.

Tài liệu tham khảo

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Alzheimer's and Dementia: Translational Research and Clinical Interventions

Tập 4

565-574

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