On the invasion of the central nervous system by nematodes: II. Invasion of the nervous system in ascariasis

Parasitology - Tập 45 Số 1-2 - Trang 41-55 - 1955
J. F. A. Sprent1
1University of Queensland Veterinary School

Tóm tắt

1. Experimental infections in mice showed that the larvae ofToxocara canis, T. mystax, Ascaris devosi, A. columnarisandToxascaris transfugareached the brain of mice; the larvae ofAscaris lumbricoides, A. suum, Parascaris equorumandToxascaris leoninawere not recovered from the brain. The larvae ofT. canis, T. mystax, T. transfugaandA. columnarisremained hi the brain of mice for several months.2. Larvae reaching the brain produced characteristic haemorrhages on the surface of the cerebral hemispheres in the early stages of infection. It was concluded that the larvae reach the brain via the arterial blood stream, leave the arteries at the point where their diameter approximates that of the larvae, i.e. mostly on the surface of the brain, and penetrate into the brain from the subarachnoid space and chorioidal tissues.3. The larvae ofT. caniswere found to occur in the brain of mice in relatively greater numbers than the larvae of other species, but only very rarely caused nervous symptoms. The larvae ofT. canisandT. mystaxshowed no growth in the brain.4. The larvae ofA. columnaris(skunk) frequently caused nervous symptoms in mice, the effect appeared to result from traumatic damage due to the relatively large size attained by these larvae about 3 weeks after infection.5. The brain of infected mice showed very slight changes consequent upon infection with larvae ofT. canis. These larvae moved actively through the tissues; they incited little or no cellular reaction, but left haemorrhagic tracks. The larvae ofA. columnarisalso moved actively; when in the extended state they were usually found in normal tissue; when coiled, they were often associated with a necrotic focus infiltrated with leucocytes.6. After experimental infections of dogs with larvae ofT. canis, two out of twelve infected animals harboured larvae in the brain. No natural infections with these larvae were found in the brains of dogs and cats. After experimental infection, larvae ofT. caniswere found in the brain of mice, rats and guinea-pigs, but not of rabbits.7. Larvae ofA. suumwere recovered from the cerebrum of one pig suffering from posterior paralysis, but not in an experimentally infected pig.8. No larvae ofP. equorumwere found in the brain of foals in natural and experimental infections.

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Tài liệu tham khảo

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Sprent, 1954, On the invasion of the central nervous system by nematodes. I. The incidence and pathological significance of nematodes in the central nervous system, Parasitology

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Parasitology

Tập 45 Số 1-2

41-55

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