On the Synergistic Effects of Ligand-Mediated and Phage-Intrinsic Properties During In Vivo Selection

Arap, 2002, Steps toward mapping the human vasculature by phage display, Nat. Med., 8, 121, 10.1038/nm0202-121 Barbas, 2001 Brown, 2004, Drug identification through in vivo screening of chemical libraries, Chembiochem, 5, 871, 10.1002/cbic.200300824 Caravan, 2007, Collagen-targeted MRI contrast agent for molecular imaging of fibrosis, Angew. Chem. Int. Ed. Engl., 46, 8171, 10.1002/anie.200700700 Cardo-Vila, 2010, From combinatorial peptide selection to drug prototype (II): Targeting the epidermal growth factor receptor pathway, Proc Natl Acad Sci USA, 107, 5118, 10.1073/pnas.0915146107 Christianson, 2007, Techniques to decipher molecular diversity by phage display, Methods Mol. Biol., 357, 385 De Mestre, 1975, Low-Reynolds-number translation of a slender cylinder near a plane wall, J. Eng. Math., 9, 81, 10.1007/BF01535390 Decuzzi, 2008, The receptor-mediated endocytosis of nonspherical particles, Biophys. J., 94, 3790, 10.1529/biophysj.107.120238 Decuzzi, 2005, A theoretical model for the margination of particles within blood vessels, Ann. Biomed. Eng., 33, 179, 10.1007/s10439-005-8976-5 Decuzzi, 2006, The effective dispersion of nanovectors within the tumor microvasculature, Ann. Biomed. Eng., 34, 633, 10.1007/s10439-005-9072-6 Decuzzi, 2009, Intravascular delivery of particulate systems: Does geometry really matter?, Pharm. Res., 26, 235, 10.1007/s11095-008-9697-x Dickson, 2004, Key factors in the rising cost of new drug discovery and development, Nat. Rev. Drug. Discov., 3, 417, 10.1038/nrd1382 Evans, 2007, Forces and bond dynamics in cell adhesion, Science, 316, 1148, 10.1126/science.1137592 Fang, 2003, Factors and mechanism of "EPR" effect and the enhanced antitumor effects of macromolecular drugs including SMANCS, Adv. Exp. Med. Biol., 519, 29, 10.1007/0-306-47932-X_2 Forgacs, 1959, Particle motions in sheared suspensions: IX. Spin and deformation of threadlike particles, J. Colloid Sci., 14, 457, 10.1016/0095-8522(59)90012-1 Forgacs, 1959, Particle motions in sheared suspensions: X. Orbits of flexible threadlike particles, J. Colloid Sci., 14, 473, 10.1016/0095-8522(59)90013-3 Geng, 2007, Shape effects of filaments versus spherical particles in flow and drug delivery, Nat. Nanotechnol., 2, 249, 10.1038/nnano.2007.70 Gestwicki, 2002, Influencing receptor-ligand binding mechanisms with multivalent ligand architecture, J. Am. Chem. Soc., 124, 14922, 10.1021/ja027184x Giordano, 2010, From combinatorial peptide selection to drug prototype (I): Targeting the vascular endothelial growth factor receptor pathway, Proc. Natl. Acad. Sci. USA, 107, 5112, 10.1073/pnas.0915141107 Goncalves, 2005, Binding of oligoarginine to membrane lipids and heparan sulfate: Structural and thermodynamic characterization of a cell-penetrating peptide, Biochemistry, 44, 2692, 10.1021/bi048046i Hajitou, 2006, Vascular targeting: Recent advances and therapeutic perspectives, Trends Cardiovasc. Med., 16, 80, 10.1016/j.tcm.2006.01.003 Helms, 2009, High-affinity peptide-based collagen targeting using synthetic phage mimics: From phage display to dendrimer display, J. Am. Chem. Soc., 131, 11683, 10.1021/ja902285m Hoffman, 2009, Tumor-targeting amino acid auxotrophic Salmonella typhimurium, Amino Acids, 37, 509, 10.1007/s00726-009-0261-8 Houghten, 2008, Strategies for the use of mixture-based synthetic combinatorial libraries: Scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods, J. Comb. Chem., 10, 3, 10.1021/cc7001205 Iyer, 2006, Exploiting the enhanced permeability and retention effect for tumor targeting, Drug Discov. Today, 11, 812, 10.1016/j.drudis.2006.07.005 Johns, 2000, In vivo selection of sFv from phage display libraries, J. Immunol. Methods, 239, 137, 10.1016/S0022-1759(00)00152-6 Khalil, 2007, Single M13 bacteriophage tethering and stretching, Proc. Natl. Acad. Sci. USA, 104, 4892, 10.1073/pnas.0605727104 Kiessling, 2006, Synthetic multivalent ligands as probes of signal transduction, Angew. Chem. Int. Ed. Engl., 45, 2348, 10.1002/anie.200502794 Kolonin, 2006, Synchronous selection of homing peptides for multiple tissues by in vivo phage display, FASEB J., 20, 979, 10.1096/fj.05-5186fje Krag, 2006, Selection of tumor-binding ligands in cancer patients with phage display libraries, Cancer Res., 66, 7724, 10.1158/0008-5472.CAN-05-4441 Lesko, 2007, Paving the critical path: How can clinical pharmacology help achieve the vision?, Clin. Pharmacol. Ther., 81, 170, 10.1038/sj.clpt.6100045 Levitan, 1998, Stochastic modeling and optimization of phage display, J. Mol. Biol., 277, 893, 10.1006/jmbi.1997.1555 Li, 2002, Microtubule structure at 8 A resolution, Structure, 10, 1317, 10.1016/S0969-2126(02)00827-4 Maeda, 2001, The enhanced permeability and retention (EPR) effect in tumor vasculature: The key role of tumor-selective macromolecular drug targeting, Adv. Enzyme Regul., 41, 189, 10.1016/S0065-2571(00)00013-3 Maeda, 2001, SMANCS and polymer-conjugated macromolecular drugs: Advantages in cancer chemotherapy, Adv. Drug Deliv. Rev., 46, 169, 10.1016/S0169-409X(00)00134-4 Maeda, 2009, Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect, Eur. J. Pharm. Biopharm., 71, 409, 10.1016/j.ejpb.2008.11.010 Mammen, 1998, Polyvalent interactions in biological systems: Implications for design and use of multivalent ligands and inhibitors, Angew. Chem. Int. Ed. Engl., 37, 2754, 10.1002/(SICI)1521-3773(19981102)37:20<2754::AID-ANIE2754>3.0.CO;2-3 Matsumura, 1986, A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs, Cancer Res., 46, 6387 Merkel, 1999, Energy landscapes of receptor-ligand bonds explored with dynamic force spectroscopy, Nature, 397, 50, 10.1038/16219 Molenaar, 2002, Uptake and processing of modified bacteriophage M13 in mice: Implications for phage display, Virology, 293, 182, 10.1006/viro.2001.1254 Nakashima, 1975, Primary structure and sidechain interactions of PFL filamentous bacterial virus coat protein, Nature, 253, 68, 10.1038/253068a0 Ozawa, 2008, Beyond receptor expression levels: The relevance of target accessibility in ligand-directed pharmacodelivery systems, Trends Cardiovasc. Med., 18, 126, 10.1016/j.tcm.2008.03.001 Park, 2002, Anti-HER2 immunoliposomes: Enhanced efficacy attributable to targeted delivery, Clin. Cancer Res., 8, 1172 Park, 2009, Systematic surface engineering of magnetic nanoworms for in vivo tumor targeting, Small, 5, 694, 10.1002/smll.200801789 Pasqualini, 1996, Organ targeting in vivo using phage display peptide libraries, Nature, 380, 364, 10.1038/380364a0 Pasqualini, 2010, Leveraging molecular heterogeneity of the vascular endothelium for targeted drug delivery and imaging, Semin. Thromb. Hemost., 36, 343, 10.1055/s-0030-1253456 Qian, 2010, Macrophage diversity enhances tumor progression and metastasis, Cell, 141, 39, 10.1016/j.cell.2010.03.014 Smith, 1997, Phage display, Chem. Rev., 97, 391, 10.1021/cr960065d Stover, 1990, The motion of rodlike particles in the pressure-driven flow between two flat plates, Rheol. Acta, 29, 192, 10.1007/BF01331355 Tasciotti, 2008, Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications, Nat. Nanotechnol., 3, 151, 10.1038/nnano.2008.34 Tornberg, 2004, Simulating the dynamics and interactions of flexible fibers in stokes flows, J. Comput. Phys., 196, 8, 10.1016/j.jcp.2003.10.017 Trepel, 2008, Chapter 4: Screening phage-display peptide libraries for vascular targeted peptides, Methods Enzymol., 445, 83, 10.1016/S0076-6879(08)03004-8 Wang, 2006, The structure of a filamentous bacteriophage, J. Mol. Biol., 361, 209, 10.1016/j.jmb.2006.06.027 Wiseman, 1976, Different arrangements of protein subunits and single-stranded circular DNA in the filamentous bacterial viruses fd and Pf1, J. Mol. Biol., 102, 549, 10.1016/0022-2836(76)90333-8 Woodcock, 2008, The FDA critical path initiative and its influence on new drug development, Annu. Rev. Med., 59, 1, 10.1146/annurev.med.59.090506.155819 Woolley, 2001, Deposition and characterization of extended SIngle-stranded DNA molecules on surfaces, Nano Lett., 1, 345, 10.1021/nl0155476 Zhang, 2002, Force spectroscopy of the leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction, Biophys. J., 83, 2270, 10.1016/S0006-3495(02)73987-8 Zhao, 2005, Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium, Proc. Natl. Acad. Sci. USA, 102, 755, 10.1073/pnas.0408422102 Zhao, 2006, Targeted therapy with a Salmonella typhimurium leucine-arginine auxotroph cures orthotopic human breast tumors in nude mice, Cancer Res., 66, 7647, 10.1158/0008-5472.CAN-06-0716 Ziegler, 2003, Protein transduction domains of HIV-1 and SIV TAT interact with charged lipid vesicles. Binding mechanism and thermodynamic analysis, Biochemistry, 42, 9185, 10.1021/bi0346805 Zimmermann, 1986, The ionic properties of the filamentous bacteriophages Pf1 and fd, J. Biol. Chem., 261, 1653, 10.1016/S0021-9258(17)35990-2 Zou, 2004, Biodistribution of filamentous phage peptide libraries in mice, Mol. Biol. Rep., 31, 121, 10.1023/B:MOLE.0000031459.14448.af