Oesophageal squamous cell carcinoma: I. A critical review of surgery

British Journal of Surgery - Tập 67 Số 6 - Trang 381-390 - 2005
Richard Earlam1, José Renan Cunha-Melo1
1The London Hospital, Whitechapel, London E1

Tóm tắt

Summary

Authors writing on oesophageal cancer include adenocarcinoma to a variable extent–between 1 and 75 per cent–but the true incidence of this histological type is about 1 per cent. Most adenocarcinomas are gastric in origin, involving the lower oesophagus, have a lower operative mortality than in the middle or upper one-third of the oesophagus and poorer prognosis than squamous cell carcinoma, but there is no alternative treatment to surgery. Squamous cell carcinoma of the oesophagus, separated incompletely but as far as possible, has been analysed by reviewing data on 83 783 patients in 122 papers. After trying to standardize the data, it appears that of 100 patients with the condition, 58 will be explored and 39 have the tumour resected, of whom 13 will die in hospital. Of the 26 patients leaving hospital with the tumour excised, 18 will survive for 1 year, 9 for 2 years and 4 for 5 years. Oesophageal resection for squamous cell carcinoma has the highest operative mortality of any routinely performed surgical procedure today.

Từ khóa


Tài liệu tham khảo

Adams, 1965, The surgical treatment of carcinoma of the esophagus; need for a more aggressive attitude, J. Thorac. Cardiovasc. Surg., 50, 141, 10.1016/S0022-5223(19)33247-7

Akakura, 1970, Surgery of carcinoma of the esophagus with preoperative radiation, Chest, 57, 47, 10.1378/chest.57.1.47

American Joint Committee, 1975, Clinical staging system for carcinoma of the esophagus, CA, 25, 50

Amman, 1971, Palliative intubation of the esophagus. Analysis of 59 cases, J. Thorac. Cardiovasc. Surg., 61, 863, 10.1016/S0022-5223(19)42148-X

Anabtawi, 1964, Carcinoma of the esophagus treated by continued radiation and surgery, J. Thorac. Cardiovasc. Surg., 48, 205, 10.1016/S0022-5223(19)32785-0

Angorn, 1978, Carcinoma of the Oesophagus, 248

Appelquist, 1972, Carcinoma of the oesophagus and gastric cardia. A retrospective study based on statistical and clinical material from Finland, Acta Chir. Scand., 1

Beattie, 1967, Treatment of carcinoma of the esophagus, Am. Surg., 33, 100

Belsey, 1974, An exclusive right thoracic approach for cancer of the middle third of esophagus, Ann. Thorac. Surg., 18, 1, 10.1016/S0003-4975(10)65712-8

Block, 1964, Adenocarcinoma of the cardioesophageal junction, Arch. Surg., 88, 852, 10.1001/archsurg.1964.01310230128025

Boyd, 1958, Carcinoma of the esophagus, N. Engl. J. Med., 258, 271, 10.1056/NEJM195802062580604

Buck, 1973, Esophageal cancer: results of therapy in an indigent population, J. Surg. Oncol., 5, 101, 10.1002/jso.2930050206

Burn, 1971, Cancer of the stomach and oesophagus. Data concerning management and results, Br. J. Surg., 58, 798, 10.1002/bjs.1800581024

Buschke, 1954, Surgical and radiological results in the treatment of esophageal carcinoma, Am. J. Roentgenol. Radium Ther. Nucl. Med., 71, 9

Carey, 1972, Esophagogastrectomy. Superiority of the combined abdominal-right thoracic approach (Lewis Operation), Ann. Thorac. Surg., 14, 59, 10.1016/S0003-4975(10)65200-9

Cederquist, 1978, Cancer of the esophagus II. Therapy and outcome, Acta Chir. Scand., 144, 233

Clark, 1968, Comparative study of symptom relief in esophageal cancer, with development of useful index of palliation, Radiology, 90, 971, 10.1148/90.5.971

Cliffton, 1960, Preoperative irradiation for cancer of the esophagus, Cancer, 13, 37, 10.1002/1097-0142(196001/02)13:1<37::AID-CNCR2820130108>3.0.CO;2-6

Coetze, 1966, Carcinoma of the esophagus, S. Afr. J. Surg., 4, 107

Collis, 1971, Surgical treatment of carcinoma of the oesophagus and cardia, Br. J. Surg., 58, 801, 10.1002/bjs.1800581025

COORDINATING GROUP FOR RESEARCH ON ESOPHAGEAL CANCER, 1976, Early diagnosis and surgical treatment of esophageal cancer under rural conditions, Chin. Med. J., 2, 113

Curto-Cardus, 1970, Findings and results in surgery of cancer of the esophagus, Rev. Esp. Enferm. Apar. Dig., 32, 505

Dor, 1963, 1 year of esophageal surgery. Statistics of the Marseilles Thoracic Surgical Clinic, Arch. Fr. Mal. App. Dig., 53, 458

Dunlop, 1961, Carcinoma of the oesophagus–reflections upon surgical treatment, Ann. R. Coll. Surg. Engl., 29, 28

Efskind, 1965, Carcinoma of the lower portion of the esophagus, Acta Chir. Scand., 110

El-Domeiri, 1970, Esophageal reconstruction by colon interposition, Arch. Surg., 100, 358, 10.1001/archsurg.1970.01340220034006

Ellis, 1960, Treatment of carcinoma of the esophagus and cardia, Mayo Clin. Proc., 35, 653

Franklin, 1964, Carcinoma of the oesophagus. A review of 129 treated patients, Br. J. Surg., 51, 178, 10.1002/bjs.1800510305

Garlock, 1954, The surgical treatment of carcinoma of the esophagus and cardia. An analysis of 457 cases, Ann. Surg., 139, 19, 10.1097/00000658-195401000-00003

Gary-Bobo, 1978, Le traitement radio-chirurgical du cancer de l-'oesophage thoracique. A propos de 143 cases, J. Radiol. Electrol. Med. Nucl., 59, 343

Giuli, 1972, Bilan de 135 interventions pour cancer du cardia: valeur de la gastrectomie totale, Sem. Hop. Paris, 26, 849

Goodner, 1959, Surgical and radiation treatment of cancer of the thoracic esophagus, Am. J. Roentgenol. Radium Ther. Nucl. Med., 105, 523, 10.2214/ajr.105.3.523

Groves, 1965, Carcinoma of the esophagus. 1965: evaluation of treatment, Ann. Thorac. Surg., 1, 416, 10.1016/S0003-4975(10)66777-X

Guernsey, 1969, Combined treatment of cancer of the esophagus, Am. J. Surg., 117, 157, 10.1016/0002-9610(69)90299-2

Guinn, 1971, Appraisal of therapy for carcinoma of the esophagus, Am. J. Surg., 122, 703, 10.1016/0002-9610(71)90305-9

Gunnlaugsson, 1970, Analysis of the records of 1,657 patients with carcinoma of the esophagus and cardia of the stomach, Surg. Gynecol. Obstet., 130, 997

Gutgemann, 1953, Zur Frage der radikalen und palliativen Operation des Oesophaguscarcinoms, Langenbecks Arch. Chir., 276, 357, 10.1007/BF02443200

Hankins, 1972, Carcinoma of the esophagus. The philosophy for palliation, Ann. Thorac. Surg., 14, 189, 10.1016/S0003-4975(10)65217-4

Humphrey, 1968, Carcinoma of the distal part of esophagus and cardia of the stomach, Surg. Gynecol. Obstet., 127, 737

Hunt, 1978, Carcinoma of the Oesophagus, 17

Inberg, 1971, Anastomostic leakage after excision of esophageal and high gastric carcinoma, Am. J. Surg., 122, 540, 10.1016/0002-9610(71)90484-3

Jackson, 1979, The surgical management of malignant tumours of the oesophagus and cardia: a review of the results in 292 patients treated over a 15-year period (1961–1975), Br. J. Surg., 66, 98, 10.1002/bjs.1800660207

Johnson, 1962, The surgical treatment of carcinoma of the esophagus and cardiac end of the stomach, Surg. Clin. North Am., 42, 1397, 10.1016/S0039-6109(16)36828-1

Just-Viera, 1976, Long-term survival of patients with carcinoma of the oesophagus in Puerto Rico, Am. Surg., 42, 62

Kasai, 1978, Follow-up results after resection of thoracic esophageal carcinoma, World J. Surg., 2, 543, 10.1007/BF01563699

Kays, 1963, A ten year appraisal of the treatment of squamous cell carcinoma of the esophagus, Surg. Gynecol. Obstet., 117, 167

Keith, 1960, Carcinoma of the esophagus, Arch. Surg., 80, 434, 10.1001/archsurg.1960.01290200078012

Killen, 1964, Carcinoma of the esophagus, J. Thorac. Cardiovasc. Surg., 48, 491, 10.1016/S0022-5223(19)33547-0

Kock, 1967, Carcinoma of the thoracic esophagus and cardia. A review of 146 cases, Acta Chir. Scand., 133, 375

Kraft-Kinz, 1969, Experiences with the surgical therapy of esophagus carcinoma, Langenbecks Arch. Chir., 324, 285, 10.1007/BF01238556

Kyllonen, 1965, On operative treatment of carcinoma of the esophagus, Acta Chir. Scand., 117

Lawler, 1969, Carcinoma of the esophagus, J. Thorac. Cardiovasc. Surg., 58, 609, 10.1016/S0022-5223(19)42577-4

Lederman, 1966, Carcinoma of the esophagus with special reference to the upper third. I. Clinical considerations, Br. J. Radiol., 39, 193, 10.1259/0007-1285-39-459-193

Leon, 1971, Carcinoma of the esophagus. A disaster, Ann. Thorac. Surg., 11, 583, 10.1016/S0003-4975(10)65078-3

Leroux, 1961, An analysis of 700 cases of carcinoma of the hypopharynx, the oesophagus and the proximal stomach, Thorax, 16, 226, 10.1136/thx.16.3.226

Leverment, 1974, Oesophagogastrectomy in the treatment of malignancy of the thoracic oesophagus and cardia, Br. J. Surg., 61, 683, 10.1002/bjs.1800610903

Loeb, 1965, Carcinoma of esophagus, Lancet, 85, 425

Logan, 1963, The surgical treatment of carcinoma of the esophagus and cardia, J. Thorac. Cardiovasc. Surg., 46, 150, 10.1016/S0022-5223(20)31564-6

Lortat-Jacob, 1969, Surgical treatment of esophageal cancer. Record of 23 years of experience, Bull Acad. Nat. Med. (Paris), 153, 17

Lowe, 1972, Survival with carcinoma of the esophagus, Ann. Intern. Med., 77, 915, 10.7326/0003-4819-77-6-915

Marchand, 1978, Carcinoma of the Oesophagus, 217

Marcial, 1966, The role of radiation therapy in esophageal cancer, Radiology, 87, 231, 10.1148/87.2.231

Marks, 1976, Preoperative radiation therapy for cancer of the esophagus, Cancer, 38, 84, 10.1002/1097-0142(197607)38:1<84::AID-CNCR2820380115>3.0.CO;2-S

Martinez, 1964, Cancer of esophagus in Puerto Rico. Mortality and incidence analysis, 1950–1961, Cancer, 17, 1278, 10.1002/1097-0142(196410)17:10<1279::AID-CNCR2820171010>3.0.CO;2-I

McKeown, 1978, Carcinoma of the oesophagus, Ann. R. Coll. Surg. Engl., 60, 301

Millburn, 1968, Curative treatment of epidermoid carcinoma of the esophagus, Am. J. Roentgenol. Radium Ther. Nucl. Med., 103, 291, 10.2214/ajr.103.2.291

Miller, 1962, Carcinoma of thoracic oesophagus and cardia. A review of 405 cases, Br. J. Surg., 49, 507, 10.1002/bjs.18004921704

Milne, 1978, Carcinoma of the Oesophagus, 428

Mohansingh, 1976, Mortality of oesophageal surgery in the elderly, Br. J. Surg., 63, 579, 10.1002/bjs.1800630804

Moor, 1968, Preliminary report of survey conducted by the Johannesburg Group of Hospitals on cancer of the oesophagus in the African. Aims, policies and results, S. Afr. Med. J., 42, 892

Morrison, 1959, The treatment of carcinoma of the esophagus; a comparison of surgery and X-ray, Surgery, 46, 516

Moseley, 1968, Squamous carcinoma of the esophagus, Surg. Gynecol. Obstet., 126, 1242

Mullard, 1960, Carcinoma of oesophagus treated by excision, Lancet, 1, 677, 10.1016/S0140-6736(60)90564-X

Mustard, 1956, Carcinoma of the esophagus. A review of 381 cases admitted to Toronto General Hospital 1937–1953 inclusive, Ann. Surg., 144, 927, 10.1097/00000658-195612000-00001

Nakayama, 1974, Gastroenterology, 3rd, 307

Nealon, 1967, Combined radiation and surgery to treat carcinoma of the esophagus, Am. J. Gastroenterol., 48, 380

Ogilvie, 1960, The surgery of the oesophagus, Br. J. Surg., 47, 457, 10.1002/bjs.18004720502

Ong, 1969, The Lewis-Tanner operation for cancer of the oesophagus, J. R. Coll. Surg. Edinb., 14, 3

Parker, 1976, Carcinoma of the esophagus. Long term results, JAMA, 235, 1018, 10.1001/jama.1976.03260360020018

Parrochia, 1970, Cancer of the esophagus. Review of 196 cases, Rev. Invest. Clin., 22, 261

Pearson, 1969, The value of radiotherapy in the management of esophageal cancer, Am. J. Roentgenol. Radium Ther. Nucl. Med., 105, 500, 10.2214/ajr.105.3.500

Pelletier, 1972, Cancer of the esophagus: therapeutic results, Can. J. Surg., 15, 30

Petrov, 1967, Resection of the thoracic esophagus for cancer, Cancer, 20, 789, 10.1002/1097-0142(1967)20:5<789::AID-CNCR2820200533>3.0.CO;2-4

Petrovsky, 1967, Our experience in the surgical treatment of malignant and benign esophageal tumours, Surgery, 62, 833

Pettit, 1957, Carcinoma of esophagus; statistical study, Am. J. Roentgenol. Radium Ther. Nucl. Med., 77, 818

Piccone, 1979, Reappraisal of esophagogastrectomy for esophageal malignancy, Am. J. Surg., 137, 32, 10.1016/0002-9610(79)90007-2

Pinch, 1966, Carcinoma of the esophagus. A twenty year study, Am. J. Surg., 111, 704, 10.1016/0002-9610(66)90045-6

Pizzocaro, 1970, Surgical treatment of carcinoma of the esophagus and of the cardia; evaluation of the immediate and remote results, Tumori, 56, 279, 10.1177/030089167005600503

Plested, 1968, A philosophy of treatment of esophageal carcinoma, Am. Surg., 34, 650

Postlethwait, 1957, Squamous cell carcinoma of the esophagus, Surg. Gynecol. Obstet., 105, 465

Procter, 1968, Carcinoma of the oesophagus. A review of 523 cases, S. Afr. J. Surg., 6, 137

Rambo, 1975, Carcinoma of the esophagus, J. Surg. Oncol., 7, 355, 10.1002/jso.2930070506

Rappaport, 1964, One stage colonic interposition following total esophagectomy, Surg. Gynecol. Obstet., 118, 602

Robertson, 1967, The results of radical surgery compared with radical radiotherapy in the treatment of squamous carcinoma of the thoracic esophagus. The case for preoperative radiotherapy, J. Thorac. Cardiovasc. Surg., 53, 430, 10.1016/S0022-5223(19)43210-8

Rodriguez-Antunez, 1969, High-dose preoperative irradiation of esophageal cancer, Radiology, 92, 377, 10.1148/92.2.377

Ross, 1974, Radiotherapy of carcinoma of the oesophagus, Proc. R. Soc. Med., 67, 395

Rossetti, 1972, Erfahrungen bei der chirurgischen Behandlung des Oesophaguscarcinoma, Chirurg, 43, 489

Roussel, 1977, Esophageal cancer in Western France. Retrospective analysis of 1400 cases, Bull. Cancer (Paris), 64, 61

Sanfelippo, 1973, Celestin tube palliation for malignant esophageal obstruction, Surg. Clin. North Am., 53, 921, 10.1016/S0039-6109(16)40097-6

Segol, 1977, Traitement radiochirurgical du cancer limite de l'oesophage, Chirurgie, 103, 791

Seitz, 1973, Clinical aspects and therapy of esophageal carcinoma, Zentralbl. Chir., 98, 721

Seymour, 1965, Preoperative X-ray therapy in cancer of the esophagus, Radiology, 85, 952, 10.1148/85.5.952

Shedd, 1955, A ten year study of carcinoma of the esophagus, Surg. Gynecol. Obstet., 101, 55

Skinner, 1976, Esophageal malignancies, experience with 110 cases, Surg. Clin. North Am., 56, 137, 10.1016/S0039-6109(16)40842-X

Smith, 1975, Carcinoma of the oesophagus: preoperative irradiation followed by planned resection for lesions in the middle and lower thirds. An interim report, Aust. NZ J. Surg., 45, 176, 10.1111/j.1445-2197.1975.tb05755.x

Spath, 1970, Present surgical possibilities in thoracic esophageal neoplasms and prognosis, Brun's Beitr. Klin. Chir., 218, 289

Stoller, 1977, Carcinoma of the esophagus; a new proposal for the evaluation of treatment, Can. J. Surg., 20, 454

Stone, 1977, Carcinoma of the gastroesophageal junction. A ten year experience with esophagogastrectomy, Am. J. Surg., 134, 70, 10.1016/0002-9610(77)90286-0

Sweet, 1954, Late results of surgical treatment of carcinoma of the esophagus, JAMA, 155, 422, 10.1001/jama.1954.03690230006002

Takita, 1977, Squamous cell carcinoma of the esophagus. A study of 153 cases, J. Surg. Oncol., 9, 547, 10.1002/jso.2930090604

Turnbull, 1968, Primary adenocarcinoma of the esophagus, Cancer, 22, 915, 10.1002/1097-0142(196811)22:5<915::AID-CNCR2820220503>3.0.CO;2-3

Van Houtte, 1977, Radiotherapy of oesophagus cancer. A review of 136 cases treated at the Institut Bordet, Acta Gastroenterol. Belg., 40, 121

Vander-Vennet, 1965, Epidermoid carcinoma of esophagus: review of 150 cases, Am. Surg., 31, 487

Wahlers, 1975, Radiotherapy of esophageal neoplasms, Strahlentherapie, 149, 252

Watson, 1963, Radiation treatment of cancer of the esophagus, Surg. Gynecol. Obstet., 117, 346

Webb, 1975, Adenocarcinoma of the oesophagus and of the oesophagogastric junction, Br. J. Surg., 65, 475, 10.1002/bjs.1800650709

Wilkins, 1975, Colon esophageal bypass, Am. J. Surg., 129, 394, 10.1016/0002-9610(75)90183-X

Wilson, 1970, Esophagogastrectomy versus radiation therapy for mid-esophageal carcinoma, Ann. Thorac. Surg., 10, 195, 10.1016/S0003-4975(10)65587-7

Wosornu, 1970, Carcinoma of the thoracic oesophagus and cardia. A 7-year review of 66 cases, Br. J. Surg., 57, 42, 10.1002/bjs.1800570110

Younghusband, 1970, Carcinoma of the oesophagus: factors influencing survival, Br. J. Surg., 57, 422, 10.1002/bjs.1800570606

Zacho, 1965, Surgical treatment of malignancies of the oesophagogastric junction, Acta Chir. Scand., 121

Zenker, 1966, Ergebnisse der chirurgischen Behandlung des Oesophaguskarcinoms, Thoraxchir. Vasc. Chir., 14, 247

Ansari, 1971, Carcinoma of the esophagus. Diagnosis and treatment, Geriatrics, 26, 98

Collis, 1966, Carcinoma of the esophagus and cardia, Acta Chir. Belg., 2, 77

McKeown, 1976, Total three-stage oesophagectomy for cancer of the oesophagus, Br. J. Surg., 63, 259, 10.1002/bjs.1800630403

Ong, 1978, Factors influencing morbidity and mortality in esophageal carcinoma, J. Thorac. Cardiovasc. Surg., 76, 745, 10.1016/S0022-5223(19)39550-9

Nakayama, 1959, Statistical review of 5 year survivals after surgery for carcinoma of the esophagus and cardiac portion of the stomach, Surgery, 45, 883

McKeown, 1972, Trends in oesophageal resection for carcinoma, Ann. R. Coll. Surg. Engl., 51, 213

Day, 1975, Some aspects of the epidemiology of esophageal cancer, Cancer Res., 35, 3304

Earlam, 1979, The epidemiology of oesophageal cancer

Hunt, 1978, Carcinoma of the Oesophagus, 287

Gillis, 1978, Carcinoma of the Oesophagus, 60

Audigier, 1975, Epidemiology of oesophageal cancer in France. Increasing mortality and persistent correlation with alcoholism, Digestion, 13, 209, 10.1159/000197710

Johnson, 1964, End results in cancer of the esophagus, Natl Cancer Inst. Monogr., 15, 221

Leroux, 1962, The influence of resection on the natural history of carcinoma of the hypopharynx, oesophagus and proximal stomach, Surg. Gynecol. Obstet., 115, 162

Parker, 1970, Carcinoma of the esophagus, Ann. Surg., 171, 746, 10.1097/00000658-197005000-00014

Uys, 1978, Carcinoma of the Oesophagus, 149

Botha, 1978, Carcinoma of the Oesophagus, 117

Raphael, 1966, Primary adenocarcinoma of the esophagus, Ann. Surg., 164, 785, 10.1097/00000658-196611000-00002

Hankins, 1974, Adenocarcinoma involving the esophagus, J. Thorac. Cardiovasc. Surg., 68, 148, 10.1016/S0022-5223(19)41702-9

Japanese Society for Esophageal Diseases, 1976, Guide lines for the clinical and pathologic studies on carcinoma of the esophagus. Part 1. Clinical classification, Jap. J. Surg., 6, 69, 10.1007/BF02468889

Japanese Society for Esophageal Diseases, 1976, Guide lines for the clinical and pathologic studies on carcinoma of the esophagus. Part II. Pathologic classification, Jap. J. Surg., 6, 79, 10.1007/BF02468890

Dukes, 1932, The classification of cancer of the rectum, J. Pathol. Bacteriol, 35, 323, 10.1002/path.1700350303

Schultz, 1973, Clinical staging system for carcinoma of the esophagus. Report of the task force on carcinoma of the esophagus, American Joint Committee for Cancer Staging and End Results Reporting, Chicago

Broders, 1926, Carcinoma grading and practical application, Arch. Pathol., 2, 376

Smit, 1978, Carcinoma of the Oesophagus, 263

Nakayama, 1974, Cancer of the GI tract. II Esophagus; treatment localised and advanced. Surgical treatment combined with preoperative concentrated irradiation, JAMA, 227, 178, 10.1001/jama.1974.03230150030008

Endo, 1978, Carcinoma of the Oesophagus, 312

Goodner, 1974, Cancer of the gastrointestinal tract II. Esophagus; treatment localised and advanced. Surgical principles of resection and reconstruction, JAMA, 227, 176, 10.1001/jama.1974.03230150028007

Fleming, 1943, Carcinoma of the thoracic oesophagus. Some notes on its pathology and spread in relation to treatment, Br. J. Radiol., 16, 212, 10.1259/0007-1285-16-187-212

Fleming, 1947, Radiotherapy in cancer of the thoracic oesophagus, Thorax, 2, 206, 10.1136/thx.2.4.206

Rubin, 1974, Cancer of the gastrointestinal tract. II. Esophagus. Treatment–localised and advanced. Pretreatment laparotomy, JAMA, 227, 184, 10.1001/jama.1974.03230150036011

Kinoshima, 1978, Carcinoma of the Oesophagus, 417

Nicks, 1973, A clinico-pathological study of some factors influencing survival in cancer of the oesophagus. A survey of ten years' experience, Aust. NZ J. Surg., 43, 3, 10.1111/j.1445-2197.1973.tb05660.x

Pearson, 1971, Radiotherapy of oesophageal cancer, Mod. Trends Surg., 3, 33

Akiyama, 1972, The esophageal axis and its relationship to the resectability of carcinoma of the esophagus, Ann. Surg., 176, 30, 10.1097/00000658-197207000-00007

Mulder, 1977, Carcinoma of the esophagus: advantages of the prospective treatment protocol, Can. J. Surg., 20, 400

Murray, 1977, The assessment of operability of esophageal carcinoma, Ann. Thorac. Surg., 23, 393, 10.1016/S0003-4975(10)64155-0

Appelquist, 1975, Carcinoma of the oesophagus and gastric cardia at autopsy in Finland, Ann. Clin. Res., 7, 334

Cederquist, 1978, Cancer of the oesophagus I. 1002 cases, survey and survival, Acta Chir. Scand., 144, 227

Pearson, 1978, Carcinoma of the Oesophagus, 334

Shackleford, 1978, Surgery of the Alimentary Tract. I. Esophagus

Ong, 1975, Unresectable carcinoma of the oesophagus, Ann. R. Coll. Surg. Engl., 56, 3