Oesophageal aspergillosis in a case of acute lymphoblastic leukaemia successfully treated with caspofungin alone due to liposomal amphotericin B induced severe hepatotoxicity

Mycoses - Tập 52 Số 1 - Trang 84-86 - 2009
Alev Akyol Erikçi1, İlker Taşçı2, Hakan Terekeci3, Akın Öztürk1, Özlem Karabudak4, Kemal Öncü5
1Department of Hematology
2Department of Microbiology
3Department of Internal Medicine
4Department of Dermatology
5Department of Gastroenterology, GATA Haydarpasa Training Hospital, Uskudar, Istanbul

Tóm tắt

SummaryAspergillosis is one of the most common invasive fungal infections in immunocompromised patients. Sinonasal region and upper respiratory tract are commonly involved regions whereas oesophagus is seldom involved. We present an 18‐year‐old male with acute lymphoblastic leukaemia with aspergillosis of oesophagus which is a rare region of involvement. The diagnosis was confirmed by the examination of the cultures of endoscopic biopsy material. The patient was already receiving empirical liposomal amphotericin B, due to severe hepatotoxicity the therapy was switched to another antifungal (caspofungin). Here we report a case of successful treatment of invasive oesophageal aspergillosis by caspofungin.

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