Occurrence of status epilepticus in persons with epilepsy is determined by sex, epilepsy classification, and etiology: a single center cohort study

Deutsche Zeitschrift für Nervenheilkunde - Tập 268 - Trang 4816-4823 - 2021
Lisa Langenbruch1, Christine Strippel1, Dennis Görlich2, Christian E. Elger1, Gabriel Möddel1, Sven G. Meuth3, Christoph Kellinghaus4, Heinz Wiendl1, Stjepana Kovac1
1Department of Neurology with Institute of Translational Neurology, University of Münster, University Hospital Münster, Münster, Germany
2Institute of Biostatistics and Clinical Research, University of Münster, Münster, Germany
3Department of Neurology, University of Düsseldorf, Düsseldorf, Germany
4Department of Neurology, Klinikum Osnabrück, Osnabrück, Germany

Tóm tắt

Status epilepticus (SE) can occur in persons with or without epilepsy and is associated with high morbidity and mortality. This survey aimed to record self-reported frequency of SE in persons with epilepsy, its association with clinical characteristics and patient level of information on SE and rescue medication. 251 persons with epilepsy at a tertiary epilepsy center were included in the study. 87 (35%) had a history of SE defined as seizure duration of more than 5 min. These patients were less likely to be seizure-free, and had a higher number of present and past anti-seizure medication. Female sex, cognitive disability, younger age at epilepsy onset, defined epilepsy etiology, and focal epilepsy were associated with a history of SE. On Cox regression analysis, female sex, defined etiology and focal classification remained significant. 67% stated that they had information about prolonged seizures, and 75% knew about rescue medication. 85% found it desirable to receive information about SE at the time of initial diagnosis of epilepsy, but only 16% had been offered such information at the time. SE is frequent among persons with epilepsy and there remain unmet needs regarding patient education.

Tài liệu tham khảo

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