Occurrence of paratesticular ganglioneuroma 18 years after concurrent adrenal ganglioneuroma and papillary thyroid carcinoma – a case report
Tóm tắt
Ganglioneuromas (GNs) are composed of mature ganglion cells and Schwann cells with a fibrous stroma; GNs are most often observed in children and young adults. The majority of non-cranial GNs are located in the retroperitoneum and posterior mediastinum. Other reported rare sites include the adrenal gland, small intestine, colon and urinary bladder. However, para-testicular GNs are even more rare. Herein, we report the case of a patient with concurrent adrenal GN and thyroid papillary carcinoma who developed paratesticular GN eighteen years later. We conclude that there is an association among papillary thyroid carcinoma, GN and MEN2 syndromes. This case report may provide important information for the proposed association. However, further studies are required.
Tài liệu tham khảo
Enzinger FM, Weiss SW. Soft tissue tumours. St Louis: Mosby; 1995. p. 929–64.
Ichikawa T, Ohtomo K, Araki T, et al. GN: CT and MR features. Br J Radiol. 1996;69:114–21.
Hanna SJ, Muneer A, Cohill SB, Miller MA. GNs in the adult scrotum. J R Soc Med. 2005;98:63.
Linos D, Tsirlis T, Kapralou A, et al. Adrenal GNs: incidentalomas with misleading clinical and imaging features. Surgery. 2011;149(1):99–105.
Soccorso G, Puls F, Richards C, et al. A GN of the sigmoid colon presenting as leading point of intussusception in a child: a case report. J Pediatr Surg. 2009;44(1):e17–20.
Scheithauer BW, Santi M, Richter ER, et al. Diffuse GNtosis and plexiform neurofibroma of the urinary bladder: report of a pediatric example and literature review. Hum Pathol. 2008;39(11):1708–12.
Thway K, Fisher C. Diffuse GNtosis in small intestine associated with neurofibromatosis type 1. Ann Diagn Pathol. 2009;13(1):50–4.
Roman Birmingham PI, Navarro Sebastian FJ, Garcia Gonzalez J, et al. Paratesticular tumors. Description of our case series through a period of 25 years. Arch Esp Urol. 2012;65(6):609–15.
Jaiprakash P. Rao AC primary paratesticular GN: a rare case in an adult. Turk Patoloji Derg. 2012;28(2):165–7.
Thwalni A, Kumar R, Shergill I. GNs in the adult scrotum. Letter to the ed J R Soc Med. 2005;98:295.
Joshi VV. Peripheral neuroblastic tumors: pathologic classification based on recommendations of international neuroblastoma pathology committee (modification of Shimada classification). Pediatr Dev Pathol. 2000;3:184–99.
De Arriba-Villamor C, Martinez-Mata A. Espinosa- Morgo H, et al: Ganglion cell tumors. Rev Neurol. 1998;27:1008–11.
Rhondeau G, Nolet S, Latour M, et al. Clinical and biochemical features of seven adult adrenal ganglioneuromas. J Clin Endocrinol Metab. 2010;95:3118–25.
Qing Y, Bin X, Jian W, et al. Adrenal GNs: a 10-year experience in a Chinese population. Surgery. 2010;147(6):854–60.
Tarantino RM, de Lacerda AM, da Cunha Neto SH, et al. Adrenal ganglioneuroma. Arq Bras Endocrinol Metab. 2012;56(4):270–4.
de Chadarévian JP, MaePascasio J, Halligan GE, et al. Malignant peripheral nerve sheath tumor arising from an adrenal ganglioneuroma in a 6-year-old boy. Pediatr Dev Pathol. 2004;7(3):277–84.
Ghali VS, Gold JE, Vincent RA, et al. Malignant peripheral nerve sheath tumor arising spontaneously from retroperitoneal ganglioneuroma: a case report, review of the literature, and immunohistochemical study. Hum Pathol. 1992 Jan;23(1):72–5.
Jung HR, Kang KJ, Kwon JH, et al. Adrenal ganglioneuroma with hepatic metastasis. J Korean Surg Soc. 2011;80(4):297–300.
Holloway KB, Flowers FP. Multiple endocrine neoplasia 2B (MEN 2B)/MEN 3. Dermatol Clin. 1995;13:99–103.
Charfi S, Ayadi L, Ellouze S, et al. Composite pheochromocytoma associated with multiple endocrine neoplasia type 2B. Ann Pathol. 2008;28:225–8.
Moline J, Eng C. Multiple endocrine neoplasia type 2: an overview. Genet Med. 2011;13:755–64.
Febrero B, Rodríguez JM, Ríos A, et al. Papillary thyroid carcinoma and multiple endocrine neoplasia type 2. J Endocrinol Investig. 2015;38(11):1233–7.
Ahn J, Lee SE, Chung YJ, Cli KC, Kim MK, Oh YS, et al. A case of papillary thyroid cancer and phrochromocytoma with ganglioneuroma. Korean J Med. 2009;76:88–9.
Marotta V, Guerra A, Sapio MR, et al. RET/PTC rearrangement in benign and malignant thyroid diseases: a clinical standpoint. Eur J Endocrinol. 2011 Oct;165(4):499–507.
Ito T, Shirahama S, Ogura K, et al. The RET gene in multiple endocrine neoplasia type 2 (MEN 2). Nihon Rinsho. 2004 May;62(5):883–8.
Lora MS, Waguespack SG, Moley JF, et al. Adrenal ganglioneuromas in children with multiple endocrine neoplasia type 2: a report of two cases. J Clin Endocrinol Metab. 2005;90:4383–7.