Occurrence of fibrates and their metabolites in source and drinking water in Shanghai and Zhejiang, China

Scientific Reports - Tập 7 Số 1
Akiko Ido1, Youhei Hiromori1, Liping Meng2, Haruki Usuda1, Hisamitsu Nagase1, Min Yang3, Jianying Hu2, Tsuyoshi Nakanishi1
1Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu, Gifu 501-1196, Japan
2College of Urban and Environmental Sciences, Peking University, No. 5 Yiheyuan Road Haidian District, Beijing, 100871, China
3Key Laboratory of Aquatic Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, 18 Shuangqing Road, Haidian District, Beijing, 100085, China

Tóm tắt

AbstractFibrates, which are widely used lipidaemic-modulating drugs, are emerging environmental pollutants. However, fibrate concentrations in the environment have not been thoroughly surveyed. Here, we determined concentrations of the most commonly used fibrates and their metabolites in source water and drinking water samples from ten drinking water treatment plants in Shanghai and Zhejiang, China, using solid-phase extraction and liquid chromatography–tandem mass spectrometry. All the target compounds were detected in at least some of the source water samples, at concentrations ranging from 0.04 ng/L (fenofibrate) to 1.53 ng/L (gemfibrozil). All the compounds except fenofibrate were also detected in at least some of the drinking water samples, at recoveries ranging from 35.5% to 91.7%, suggesting that these compounds are poorly removed by typical drinking water treatment processes. In a peroxisome proliferator-activated receptor α agonistic activity assay, the target compounds showed no significant activity at nanogram per litre concentrations; therefore, our results suggest that the fibrate concentrations in drinking water in Shanghai and Zhejiang, China do not significantly affect human health. However, because of the increasing westernization of the Chinese diet, fibrate use may increase, and thus monitoring fibrate concentrations in aquatic environments and drinking water in China will become increasingly important.

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Tài liệu tham khảo

Weston, A., Caminada, D., Galicia, H. & Fent, K. Effects of lipid-lowering pharmaceuticals bezafibrate and clofibric acid on lipid metabolism in fathead minnow (Pimephales promelas). Environ. Toxicol. Chem. 28, 2648–2655 (2009).

Hernando, M. D., Agueera, A. & Fernandez-Alba, A. R. LC-MS analysis and environmental risk of lipid regulators. Anal. Bioanal. Chem. 387, 1269–1285 (2007).

European Commission. Technical Guidance Document on Risk assessment (TGD) in support of Commission Directive 93/67/ECC, Commission Regulation (EC) No 1488/94 and Directive 98/8/EC, Institute for Health and Consumer Protection, European Chemicals Bureau, Ispra, Italy Available at https://echa.europa.eu/documents/10162/16960216/tgdpart2_2ed_en.pdf (accessed 10 February 2017) (2003).

Sanderson, H. et al. Ranking and prioritization of environmental risks of pharmaceuticals in surface waters. Regul. Toxicol. Pharmacol. 39, 158–183 (2004).

Daughton, C. G. & Ternes, T. A. Pharmaceuticals and personal care products in the environment: agents of subtle change? Environ. Health Perspect. Suppl. 107, 907–938 (1999).

Kubota, R., Suzuki, T., Tahara, M., Shimizu, K. & Nishimura, T. Monitoring of PPCPs in Aquatic Environments in Japan and Evaluation of Removal Efficiency on Assumption of Water Purification Process. Journal of Japan Society on Water Environment 31, 643–649 (2008).

Qiao, T., Yu, Z., Zhang, X. & Au, D. W. T. Occurrence and fate of pharmaceuticals and personal care products in drinking water in southern China. J. Environ. Monit. 13, 3097–3103 (2011).

Stolker, A. A. M. et al. Liquid chromatography with triple-quadrupole or quadrupole-time of flight mass spectrometry for screening and confirmation of residues of pharmaceuticals in water. Anal. Bioanal. Chem. 378, 955–963 (2004).

Sui, Q., Huang, J., Deng, S. B. & Yu, G. Rapid determination of pharmaceuticals from multiple therapeutic classes in wastewater by solid-phase extraction and ultra-performance liquid chromatography tandem mass spectrometry. Chin. Sci. Bull. 54, 4633–4643 (2009).

Chen, M. et al. Pharmaceuticals and endocrine disruptors in wastewater treatment effluents and in the water supply system of Calgary, Alberta, Canada. Water Qual. Res. J. Can. 41, 351–364 (2006).

Heberer, T. Tracking persistent pharmaceutical residues from municipal sewage to drinking water. J. Hydrol. (Amsterdam, Neth.) 266, 175–189 (2002).

Mompelat, S., Le Bot, B. & Thomas, O. Occurrence and fate of pharmaceutical products and by-products, from resource to drinking water. Environ. Int. 35, 803–814 (2009).

Carmona, E., Andreu, V. & Pico, Y. Occurrence of acidic pharmaceuticals and personal care products in Turia River Basin: From waste to drinking water. Sci. Total Environ. 484, 53–63 (2014).

Vulliet, E., Cren-Olive, C. & Grenier-Loustalot, M.-F. Occurrence of pharmaceuticals and hormones in drinking water treated from surface waters. Environ. Chem. Lett. 9, 103–114 (2011).

Yi, L., Jiao, W., Chen, X. & Chen, W. An overview of reclaimed water reuse in China. J Environ Sci (China) 23, 1585–1593 (2011).

Quintana, J. B. & Reemtsma, T. Sensitive determination of acidic drugs and triclosan in surface and wastewater by ion-pair reverse-phase liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 18, 765–774 (2004).

Pyper, S. R., Viswakarma, N., Yu, S. & Reddy, J. K. PPARα: energy combustion, hypolipidemia, inflammation and cancer. Nucl. Recept. Signaling 8 (2010).

Raldua, D., Andre, M. & Babin, P. J. Clofibrate and gemfibrozil induce an embryonic malabsorption syndrome in zebrafish. Toxicol. Appl. Pharmacol. 228, 301–314 (2008).

Guyton, K. Z. et al. A reexamination of the PPAR-α activation mode of action as a basis for assessing human cancer risks of environmental contaminants. Environ. Health Perspect. 117, 1664–1672 (2009).

Nakanishi, T. et al. Trialkyltin compounds bind retinoid X receptor to alter human placental endocrine functions. Mol. Endocrinol. 19, 2502–2516 (2005).

Kawagoshi, Y., Fujita, Y., Kishi, I. & Fukunaga, I. Estrogenic chemicals and estrogenic activity in leachate from municipal waste landfill determined by yeast two-hybrid assay. J. Environ. Monit. 5, 269–274 (2003).

Inoue, D. et al. Contamination with retinoic acid receptor agonists in two rivers in the Kinki region of Japan. Water Res. 44, 2409–2418 (2010).

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