Occurrence of co-existing bla VIM-2 and bla NDM-1 in clinical isolates of Pseudomonas aeruginosa from India

Patel G, Bonomo RA. “Stormy waters ahead”: global emergence of carbapenemases. Front Microbiol. 2013;48:1–17.

Cornaglia G, Giamarellou H, Rossolini GM. Metallo-β-lactamase: a last frontier for β lactams? Lancet Infect Dis. 2011;11:381–93.

Tato M, Coque TM, Baquero F, Canton R. Dispersal of carbapenemase bla VIM-1 gene associated with different Tn402 variants, mercury transposons and conjugative plasmids in enterobacteriaceae and Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2010;54:320–7.

Yong D, Toleman MA, Giske CG, Cho HS, Sundman K, Lee K. Characterization of a New Metallo-β-Lactamase Gene, bla NDM-1, and a Novel Erythromycin Esterase Gene Carried on a Unique Genetic Structure in Klebsiella pneumoniae Sequence Type 14 from India. Antimicrob Agents Chemother. 2009;53:5046–54.

Castanheira M, Bell JM, Turnidge JD, Mathai D, Jones RN. Carbapenem resistance among Pseudomonas aeruginosa strains from India: evidence for nationwide endemicity of multiple metallo-beta-lactamase clones (VIM-2,-5,-6, and -11 and the newly characterized VIM-18). Antimicrob Agents Chemother. 2009;53:1225–7.

Kumarasamy KK, Toleman MA, Walsh TR, Bagaria J, Butt F, Balakrishnan R, Chaudhary U, Doumith M, Giske CG, Irfan S, Krishnan P, Kumar AV, Maharjan S, Mushtaq S, Noorie T, Paterson D, Pearson A, Perry C, Pike R, Rao B, Ray U, Sarma JB, Sharma M, Sheridan E, Thirunarayan MA, Turton J, Upadhyay S, Warner M, Welfare W, Livermore DM, Woodford N. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect Dis. 2010;10:597–602.

Colee JG, Diguid JP, Mackie Fraser AG, Microbiology McCartney Practical Medical. 14th edn. Edinburgh: Churchill, Livingstone; 1996.

Jh Y. Yi K, Lee H, Yong D, Lee K, Kim JM, Rossolini GM, Chong Y. Molecular characterization of metallo-β-lacatamase-producing Acinetobacter baumannii and Acinetbacter genomospecies 3 from Korea: identification of two new integrons carrying the bla VIM-2 gene cassettes. J Antimicrob Chemother. 2002;49:837–40.

Lee S, Park YJ, Kim M, Lee HK, Han K, Kang CS. Prevalence of Ambler class A and D β- lactamases among clinical isolates of Pseudomonas aeruginosa in Korea. J Antimicrob Chemother. 2005;56:122–7.

Koeleman JGM, Stoof J, Der Bijl MWV, Vandenbroucke-grauls CMJE, Savelkoul PHM. Identification of Epidemic Strains of Acinetobacter baumannii by Integrase Gene PCR. J Clin Microbiol. 2001;39:8–13.

Toleman MA, Spencer J, Jones L, Walsh TR. bla NDM-1 is a chimera likely constructed in Acinetobacter baumannii. Antimicrob Agents Chemother. 2012;56:2773.

Carattoli A, Bertini A, Villa L, Falbo V, Hopkins KL, Threlfall EJ. Identification of plasmids by PCR-based replicon typing. J Microbiol Methods. 2005;63:219–28.

Clinical Laboratory Standard Institute. Performance Standards for Antimicrobial Susceptibility Testing; Twenty-Third Informational Supplement. 2013; M100-S23. CLSI, Wayne.

Locke JB, Rahawi S, LaMarre J, Mankin LS, Shawa KJ. Genetic Environment and Stability of cfr in Methicillin-resistant Staphylococcus aureus CM05. Antimicrob Agents and Chemother. 2012;56:332–40.

Tato M, Coque TM, Ruiz-Garbajosa P, Pintado V, Cobo J, Sader HS, Jones RN, Baquero F. Complex clonal and plasmid epidemiology in the first outbreak of enterobacteriaceae infection involving VIM-1 metallo-β-lactamase in Spain: towards endemicity? Clin Infect Dis. 2007;45:1171–8.

Toleman MA, Vinodh H, Sekar U, Kamat V, Walsh TR. bla VIM-2- harboring integrons isolated in India, Russia, and the United States arise from an ancestral class 1 integron predating the formation of the 3/conserved sequence. Antimicrob Agents and Chemother. 2007;51:2636–8.

Jovcic B, Lepsanovic Z, Suljagic V, Rackov G, Begovic J, Topisirovic L, Kojic M. Emergence of NDM-1 metallo-β-lactamase in Pseudomonas aeruginosa clinical isolates from Servia. Antimicrob Agents Chemother. 2011;55:3929–31.

Jovcic B, Lepsanovic Z, Begovic J, Rakonjac B, Perovanovic J, Topisirovic L, Kojic M. The clinical isolate Pseudomonas aeruginosa MMA83 carries two copies of the bla NDM-1 gene in a novel genetic context. Antimicrob Agents Chemother. 2013;57:3405–7.

Mishra S, Upadhyay S, Sen MR, Maurya AP, Choudhury D, Bhattacharjee A. Genetic Acquisition of NDM Gene Offers Sustainability among Clinical Isolates of Pseudomonas aeruginosa in Clinical Settings. PLoS ONE. 2015;10(1):e0116611. doi: 10.1371/journal.pone.0116611 .

Paul D, Dhar Chanda D, Maurya AP, Mishra S, Chakravarty A, Sharma GD, Bhattacharjee A. Co-Carriage of bla KPC-2 and bla NDM-1 in Clinical Isolates of Pseudomonas aeruginosa Associated with Hospital Infections from India. PLoS ONE. 2015;10(12):e0145823. doi: 10.1371/journal.pone.0145823 .