Occupational exposure to chlorinated solvents and risk of head and neck cancer in men: a population-based case-control study in France
Tóm tắt
Few epidemiological studies have investigated the link between occupational exposure to solvents and head and neck cancer risk, and available findings are sparse and inconsistent. The objective of this study was to examine the association between occupational exposure to chlorinated solvents and head and neck cancer risk. We analyzed data from 4637 men (1857 cases and 2780 controls) included in a population-based case-control study, ICARE (France). Occupational exposure to five chlorinated solvents (perchloroethylene [PCE], trichloroethylene [TCE], methylene chloride [MC], chloroform [CF], and carbon tetrachloride [CT]) was assessed through job-exposure matrices. Odds ratios (ORs) and confidence intervals (95% CI) were estimated by unconditional logistic regression, adjusted for age, tobacco smoking, alcohol consumption, asbestos exposure, and other potential confounders. We observed no association between chlorinated solvent exposure and head and neck cancer risk, despite a non-significant increase in risk among subjects who had the highest cumulative level of exposure to PCE, (OR = 1.81; 95% CI = 0.68 to 4.82). In subsite analysis, the risk of laryngeal cancer increased with cumulative exposure to PCE (p for trend = 0.04). The OR was 3.86 (95% CI = 1.30 to 11.48) for those exposed to the highest levels of PCE. A non-significant elevated risk of hypopharyngeal cancer was also observed in subjects exposed to the highest levels of MC (OR = 2.36; 95% CI = 0.98 to 5.85). Our findings provide evidence that high exposure to PCE increases the risk of laryngeal cancer, and suggest an association between exposure to MC and hypopharyngeal cancer. Exposure to other chlorinated solvents was not associated with the risk of head and neck cancer.
Tài liệu tham khảo
Fevotte J, Dananche B, Delabre L, Ducamp S, Garras L, Houot M, et al. Matgene: A Program to Develop Job-Exposure Matrices in the General Population in France. Ann Occup Hyg. 2011;55:865–78.
Bakke B, Stewart PA, Waters MA. Uses of and exposure to trichloroethylene in U.S. industry: a systematic literature review. J Occup Environ Hyg. 2007;4:375–90.
Gold LS, Roos AJD, Waters M, Stewart P. Systematic Literature Review of Uses and Levels of Occupational Exposure to Tetrachloroethylene. J Occup Environ Hyg. 2008;5:807–39.
Gomez MR, Cocco P, Dosemeci M, Stewart PA. Occupational exposure to chlorinated aliphatic hydrocarbons: Job exposure matrix. Am J Ind Med. 1994;26:171–83.
Guha N, Loomis D, Grosse Y, Lauby-Secretan B, Ghissassi FE, Bouvard V, et al. Carcinogenicity of trichloroethylene, tetrachloroethylene, some other chlorinated solvents, and their metabolites. Lancet Oncol. 2012;13:1192–3.
Benbrahim-Tallaa L, Lauby-Secretan B, Loomis D, Guyton KZ, Grosse Y, El Ghissassi F, et al. Carcinogenicity of perfluorooctanoic acid, tetrafluoroethylene, dichloromethane, 1,2-dichloropropane, and 1,3-propane sultone. Lancet Oncol. 2014;15:924–5.
International Agency for Research on Cancer. Re-evaluation of some organic chemicals, hydrazine and hydrogen peroxide. Lyon: IARC; 1999.
Paget-Bailly S, Cyr D, Luce D. Occupational exposures to asbestos, polycyclic aromatic hydrocarbons and solvents, and cancers of the oral cavity and pharynx: a quantitative literature review. Int Arch Occup Environ Health. 2012;85:341–51.
Paget-Bailly S, Guida F, Carton M, Menvielle G, Radoï L, Cyr D, et al. Occupation and head and neck cancer risk in men: results from the ICARE study, a French population-based case–control study. J Occup Environ Med. 2013;55:1065–73.
Coble JB, Brown LM, Hayes RB, Huang W-Y, Winn DM, Gridley G, et al. Sugarcane Farming, Occupational Solvent Exposures, and the Risk of Oral Cancer in Puerto Rico: J. Occup Environ Med. 2003;45:869–74.
Berrino F, Richiardi L, Boffetta P, Estève J, Belletti I, Raymond L, et al. Occupation and larynx and hypopharynx cancer: a job-exposure matrix approach in an international case-control study in France, Italy, Spain and Switzerland. Cancer Causes Control CCC. 2003;14:213–23.
Elci OC, Akpinar-Elci M, Blair A, Dosemeci M. Risk of Laryngeal Cancer by Occupational Chemical Exposure in Turkey. J Occup Environ Med. 2003;45:1100–6.
Shangina O. Occupational Exposure and Laryngeal and Hypopharyngeal Cancer Risk in Central and Eastern Europe. Am J Epidemiol. 2006;164:367–75.
Vaughan TL, Stewart PA, Davis S, Thomas DB. Work in dry cleaning and the incidence of cancer of the oral cavity, larynx, and oesophagus. Occup Environ Med. 1997;54:692–5.
Luce D, Stücker I, Group I study. Investigation of occupational and environmental causes of respiratory cancers (ICARE): a multicenter, population-based case-control study in France. BMC Public Health. 2011;11:928.
Mattei F, Guida F, Matrat M, Cenee S, Cyr D, Sanchez M, et al. Exposure to chlorinated solvents and lung cancer: results of the ICARE study. Occup Environ Med. 2014;71:681–9.
Carton M, Barul C, Menvielle G. Occupational exposure to solvents and risk of head and neck cancer in women: a poppulation-based case-control study in France. BMJ Open. 2016;6:e012833.
International Labour Office. International Standard Classification of Occupations (ISCO). Geneva: International Labour Office; 1968.
Institut National de la Statistique et Des Etudes Economiques. Nomenclature d’activités française. Paris: INSEE; 2000.
Lacourt A, Leffondre K, Gramond C, Ducamp S, Rolland P, Gilg Soit Ilg A, et al. Temporal patterns of occupational asbestos exposure and risk of pleural mesothelioma. Eur Respir J. 2012;39:1304–12.
Paget-Bailly S, Cyr D, Luce D. Occupational exposures and cancer of the larynx-systematic review and meta-analysis. J Occup Environ Med Am Coll Occup Environ Med. 2012;54:71–84.
Purdue MP, Järvholm B, Bergdahl IA, Hayes RB, Baris D. Occupational exposures and head and neck cancers among Swedish construction workers. Scand J Work Environ Health. 2006;32:270–5.
Blair A, Hartge P, Stewart PA, McAdams M, Lubin J. Mortality and cancer incidence of aircraft maintenance workers exposed to trichloroethylene and other organic solvents and chemicals: extended follow up. Occup Environ Med. 1998;55:161–71.
Raaschou-Nielsen O. Cancer Risk among Workers at Danish Companies using Trichloroethylene: A Cohort Study. Am J Epidemiol. 2003;158:1182–92.
Hansen J, Sallmen M, Selden AI, Anttila A, Pukkala E, Andersson K, et al. Risk of Cancer Among Workers Exposed to Trichloroethylene: Analysis of Three Nordic Cohort Studies. JNCI J Natl Cancer Inst. 2013;105:869–77.
Radican L, Blair A, Stewart P, Wartenberg D. Mortality of Aircraft Maintenance Workers Exposed to Trichloroethylene and Other Hydrocarbons and Chemicals: Extended Follow-Up: J. Occup Environ Med. 2008;50:1306–19.
Boice JD, Marano DE, Cohen SS, Mumma MT, Blot WJ, Brill AB, et al. Mortality among Rocketdyne workers who tested rocket engines, 1948-1999. J Occup Environ Med Am Coll Occup Environ Med. 2006;48:1070–92.
Boice JD, Marano DE, Fryzek JP, Sadler CJ, McLaughlin JK. Mortality among aircraft manufacturing workers. Occup Environ Med. 1999;56:581–97.
Ruder AM, Ward EM, Brown DP. Mortality in dry-cleaning workers: An update. Am J Ind Med. 2001;39:121–32.
Blair A, Petralia SA, Stewart PA. Extended mortality follow-up of a cohort of dry cleaners. Ann Epidemiol. 2003;13:50–6.
Cooper GS, Scott CS, Bale AS. Insights from Epidemiology into Dichloromethane and Cancer Risk. Int J Environ Res Public Health. 2011;8:3380–98.
Hearne FT, Pifer JW. Mortality study of two overlapping cohorts of photographic film base manufacturing employees exposed to methylene chloride. J Occup Environ Med. 1999;41:1154–69.
Lanes SF, Rothman KJ, Dreyer NA, Soden KJ. Mortality update of cellulose fiber production workers. Scand J Work Environ Health. 1993;19:426–8.
Blair A, Stewart P, Lubin JH, Forastiere F. Methodological issues regarding confounding and exposure misclassification in epidemiological studies of occupational exposures. Am J Ind Med. 2007;50:199–207.
Ligier K, Belot A, Launoy G, Velten M, Bossard N, Iwaz J, et al. Descriptive epidemiology of upper aerodigestive tract cancers in France: Incidence over 1980–2005 and projection to 2010. Oral Oncol. 2011;47:302–7.