Nutrigenetics and Nutrigenomics Insights into Diabetes Etiopathogenesis

Georgoulis, 2014, Mediterranean diet and diabetes: Prevention and treatment, Nutrients, 6, 1406, 10.3390/nu6041406

International Diabetes Federation (2013). IDF Diabetes Atlas, International Diabetes Federation. [6th ed.].

Dib, 2009, Etiopathogenesis of type 1 diabetes mellitus: Prognostic factors for the evolution of residual beta cell function, Diabetol. Metab. Syndr., 1, 1, 10.1186/1758-5996-1-25

Hansen, 2005, Genetics of type 2 diabetes mellitus: Status and perspectives, Diabetes Obes. Metab., 7, 122, 10.1111/j.1463-1326.2004.00396.x

Schulze, 2005, Primary prevention of diabetes: What can be done and how much can be prevented?, Annu. Rev. Public Health, 26, 445, 10.1146/annurev.publhealth.26.021304.144532

Corella, 2009, Nutrigenomics in cardiovascular medicine, Circ. Cardiovasc. Genet., 2, 637, 10.1161/CIRCGENETICS.109.891366

Brennan, R.O. (1976). Nutrigenetics: New Concepts for Relieving Hypoglycemia, M. Evans and Company Inc.

Corella, 2013, Mediterranean diet reduces the adverse effect of the TCF7L2-rs7903146 polymorphism on cardiovascular risk factors and stroke incidence: A randomized controlled trial in a high-cardiovascular-risk population, Diabetes Care, 36, 3803, 10.2337/dc13-0955

Daar, 2007, Grand challenges in chronic non-communicable diseases, Nature, 450, 494, 10.1038/450494a

Scott, 1987, Molecular genetics of common diseases, Br. Med. J., 295, 769, 10.1136/bmj.295.6601.769

Sladek, 2007, A genome-wide association study identifies novel risk loci for type 2 diabetes, Nature, 445, 881, 10.1038/nature05616

Stratigopoulos, 2008, Regulation of FTO/FTM gene expression in mice and humans, Am. J. Physiol. Regul. Integr. Comp. Physiol., 294, R1185, 10.1152/ajpregu.00839.2007

Thorisson, 2003, The SNP Consortium website: Past, present and future, Nucleic Acid Res., 31, 124, 10.1093/nar/gkg052

Mitchell, 2005, On the probability that a novel variant is a disease-causing mutation, Genome Res., 15, 960, 10.1101/gr.3761405

Wilson, 2011, Linkage analysis in the next generation sequencing era, Hum. Hered., 72, 228, 10.1159/000334381

Zanda, 2014, A genome-wide assessment of the role of untagged copy number variants in type 1 diabetes, PLoS Genet., 29, e1004367, 10.1371/journal.pgen.1004367

Ziegler, 2010, Prediction and pathogenesis in type 1 diabetes, Immunity, 32, 468, 10.1016/j.immuni.2010.03.018

Virtanen, 2003, Nutritional risk predictors of beta-cell autoimmunity and type 1 diabetes at a young age, Am. J. Clin. Nutr., 78, 1053, 10.1093/ajcn/78.6.1053

Knip, 2011, Early feeding risk of type 1 diabetes: Experiences from the Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk (TRIGR), Am. J. Clin. Nutr., 94, 1814S, 10.3945/ajcn.110.000711

Norris, 2003, Timing of initial cereal exposure in infancy and risk of islet autoimmunity, JAMA, 290, 1713, 10.1001/jama.290.13.1713

Reunanen, 2001, Intake of vitamin D and risk of type 1 diabetes: A birth-cohort study, Lancet, 358, 1500, 10.1016/S0140-6736(01)06580-1

Sildorf, 2012, Remission without insulin therapy on gluten-free diet in a 6-year old boy with type 1 diabetes mellitus, BMJ Case Rep., 2012, bcr0220125878, 10.1136/bcr.02.2012.5878

Wu, 2011, Linking long-term dietary patterns with gut microbial enterocytes, Science, 334, 105, 10.1126/science.1208344

Patrick, 2013, Promotion of autoimmune diabetes by cereal diet in the presence or absence of microbes associated with gut immune activation, regulatory imbalance, and altered cathelicidin antimicrobial peptide, Diabetes, 62, 2036, 10.2337/db12-1243

Bobbala, 2012, Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse, Diabetologia, 55, 3010, 10.1007/s00125-012-2675-1

Sakaguchi, 2006, Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease, Immunol. Rev., 212, 8, 10.1111/j.0105-2896.2006.00427.x

Salmond, 2009, T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance, Immunol. Rev., 228, 9, 10.1111/j.1600-065X.2008.00745.x

Nijnik, 2009, Human cathelicidin peptide LL-37 modulates the effects of IFN-gamma on APCs, J. Immunol., 183, 5788, 10.4049/jimmunol.0901491

Phillips, 2013, Nutrigenetics and metabolic disease: Current status and implications for personalized nutrition, Nutrients, 5, 32, 10.3390/nu5010032

Vimaleswaran, 2010, Progress in the genetics of common obesity and type 2 diabetes, Expert Rev. Mol. Med., 12, e7, 10.1017/S1462399410001389

Stefanov, 2012, Lifestyle and genetics in obesity and type 2 diabetes, Exp. Clin. Endocrinol. Diabetes, 120, 1, 10.1055/s-0031-1285832

Kaput, 2007, Application of nutrigenomic concepts to type 2 diabetes mellitus, Nutr. Metab. Cardiovasc. Dis., 17, 89, 10.1016/j.numecd.2006.11.006

Flint, 2005, Strategies for mapping and cloning quantitative trait genes in rodents, Nat. Rev. Genet., 6, 271, 10.1038/nrg1576

Kaput, 2007, Complexity of type 2 diabetes mellitus data sets emerging from nutrigenomic research: A case for dimensionality reduction?, Mutat. Res., 622, 19, 10.1016/j.mrfmmm.2007.02.033

Hindorff, L.A., MacArthur, J., Morales, J., Junkins, H.A., Hall, P.N., Klemm, A.K., and Manolio, T.A. A Catalog of Published Genome-Wide Association Studies, Available online: http://www.genome.gov/gwastudies.

Dupuis, 2010, New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk, Nat. Genet., 42, 105, 10.1038/ng.520

McCarthy, 2010, Genomics, type 2 diabetes, and obesity, N. Engl. J. Med., 363, 2339, 10.1056/NEJMra0906948

Saxena, 2010, Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge, Nat. Genet., 42, 142, 10.1038/ng.521

Strawbridge, 2011, Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes, Diabetes, 60, 2624, 10.2337/db11-0415

Florez, 2008, Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: Where are the insulin resistance genes?, Diabetologia, 51, 1100, 10.1007/s00125-008-1025-9

Grant, 2006, Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes, Nat. Genet., 38, 320, 10.1038/ng1732

Zeggini, 2007, TCF7L2: The biggest story in diabetes genetics since HLA?, Diabetologia, 50, 1, 10.1007/s00125-006-0507-x

Chandak, 2007, Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population, Diabetologia, 50, 63, 10.1007/s00125-006-0502-2

Horikoshi, 2007, A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population, Diabetologia, 50, 747, 10.1007/s00125-006-0588-6

Lehman, 2007, Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans, Diabetes, 56, 389, 10.2337/db06-0860

Helgason, 2007, Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution, Nat. Genet., 39, 218, 10.1038/ng1960

Lyssenko, 2007, Mechanisms by which common variants in the TCF7L2 gene increase the risk of type 2 diabetes, J. Clin. Investig., 117, 2155, 10.1172/JCI30706

Cornelis, 2012, Gene-enviroment interactions in the development of type 2 diabetes: Recent progress and continuing challenges, Annu. Rev. Nutr., 32, 245, 10.1146/annurev-nutr-071811-150648

Lee, 2011, A database of gene-enviroment interactions pertaining to blood lipid traits, cardiovascular disease and type 2 diabetes, J. Data Mining Genomics Proteomics, 2, 106, 10.4172/2153-0602.1000106

Harrington, 2014, Nutrigenetics: Bridging two worlds to understand type 2 diabetes, Curr. Diabetes Rep., 14, 477, 10.1007/s11892-014-0477-1

Gouda, 2010, The association between the peroxisome proliferator-activated-receptor gamma 2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: HuGe review and meta-analysis, Am. J. Epidemiol., 171, 645, 10.1093/aje/kwp450

Lamri, 2012, Dietary fat intake and polymorphisms at the PPARG locus modulate BMI and type 2 diabetes risk in the D.E.S.I.R. prospective study, Int. J. Obes., 36, 218, 10.1038/ijo.2011.91

Luan, 2001, Evidence for gene-nutrient interaction at the PPARgamma locus, Diabetes, 50, 686, 10.2337/diabetes.50.3.686

Ruchat, 2009, Evidence of interaction between type 2 diabetes susceptibility genes and dietary fat intake for adiposity and glucose homeostasis-related phenotypes, J. Nutrigenet. Nutrigenomics, 2, 225

Cornelis, 2009, TCF7L2, dietary carbohydrate, and risk of type 2 diabetes in US women, Am. J. Clin. Nutr., 89, 1256, 10.3945/ajcn.2008.27058

Asensio, 2012, Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low, Cardiovasc. Diabetol., 11, 137, 10.1186/1475-2840-11-137

Steemburgo, 2013, The rs9939609 polymorphism in the FTO gene is associated with fat and fiber intakes in patients with type 2 diabetes, J. Nutrigenet. Nutrigenomics, 6, 97

Kanoni, 2011, Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: A 14-cohort meta-analysis, Diabetes, 60, 2407, 10.2337/db11-0176

Hruby, 2013, Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE Consortium Studies, J. Nutr., 143, 345, 10.3945/jn.112.172049

Patel, 2013, Systematic identification of interactions effects between genome- and environment-wide associations in type 2 diabetes mellitus, Hum. Genet., 132, 495, 10.1007/s00439-012-1258-z

Zheng, 2014, Circulating 25-hydroxyvitamin D, IRS1 variant rs2943641, and insulin resistance: Replication of a gene-nutrient interaction in 4 populations of different ancestries, Clin. Chem., 60, 186, 10.1373/clinchem.2013.215251

Nettleton, 2010, Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: A meta-analysis of 14 cohort studies, Diabetes Care, 33, 2684, 10.2337/dc10-1150

Hwang, 2013, Carbohydrate intake interacts with SNP276G > T polymorphism in the adiponectin gene to affect fasting blood glucose, HbA1C, and HDL cholesterol in Korean patients with type 2 diabetes, J. Am. Coll. Nutr., 32, 143, 10.1080/07315724.2013.791795

Hara, 2002, Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population, Diabetes, 51, 536, 10.2337/diabetes.51.2.536

Yang, 2007, Adiponectin SNP276 is associated with obesity, metabolic syndrome, and diabetes in the elderly, Am. J. Clin. Nutr., 86, 509, 10.1093/ajcn/86.2.509

Jang, 2006, The SNP276 G > T polymorphism in the adiponectin (ACDC) gene is more strongly associated with insulin resistance and cardiovascular disease risk than SNP45 T > G in nonobese/nondiabetic Korean men independent of abdominal adiposity and circulating plasma adiponectin, Metabolism, 55, 59, 10.1016/j.metabol.2005.07.007

Alsaleh, 2013, Adiponectin gene variant interacts with fish oil supplementation to influence serum adiponectin in older individuals, J. Nutr., 143, 1021, 10.3945/jn.112.172585

Gomez, 2005, The Ala54Thr polymorphism of the fatty acid-binding protein 2 gene is associated with a change in insulin sensitivity after a change in the type of dietary fat, Am. J. Clin. Nutr., 82, 196, 10.1093/ajcn/82.1.196

Fisher, 2011, A two-step association study identifies CAV2 rs2270188 single nucleotide polymorphism interaction with fat intake in type 2 diabetes risk, J. Nutr., 141, 177, 10.3945/jn.110.124206

Corella, 2006, Perilipin gene variation determines higher susceptibility to insulin resistance in Asian women when consuming a high-saturated fat, low-carbohydrate diet, Diabetes Care, 29, 1313, 10.2337/dc06-0045

Philipis, 2013, A gene variation (rs12691) in the CCAT/enhancer binding protein α modulates glucose metabolism in metabolic syndrome, Nutr. Metab. Cardiovasc., 23, 417, 10.1016/j.numecd.2011.09.008

Garaulet, 2014, Beneficial effect of CLOCK gene polymorphism rs1801260 in combination with low-fat diet on insulin metabolism in patients with metabolic syndrome, Chronobiol. Int., 31, 401, 10.3109/07420528.2013.864300

Dashti, 2014, CRY1 circadian gene variants interacts with carbohydrate intake for insulin resistance in two independent populations: Mediterranean and North American, Chronobiol. Int., 31, 660, 10.3109/07420528.2014.886587

Botden, 2012, Variants in the SIRT1 gene may affect diabetes risk in interaction with prenatal exposure to famine, Diabetes Care, 35, 424, 10.2337/dc11-1203

Lazar, 2005, PPAR gamma, 10 years later, Biochimie, 87, 9, 10.1016/j.biochi.2004.10.021

Fisher, 2009, Whole-grain consumption and transcription factor-7-like 2 (TCF7L2) rs7903146: Gene-diet interaction in modulating type 2 diabetes risk, Br. J. Nutr., 101, 478, 10.1017/S0007114508020369

Florez, 2006, TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program, N. Engl. J. Med., 355, 241, 10.1056/NEJMoa062418

Haupt, 2010, Gene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a population at risk for type 2 diabetes, GDiabetes, 59, 747, 10.2337/db09-1050

Reinehr, 2008, Evidence for an influence of TCF7L2 polymorphism rs7903146 on insulin resistance and sensitivity indices in overweight children and adolescents during a lifestyle intervention, Int. J. Obes., 32, 1521, 10.1038/ijo.2008.146

Chimienti, 2013, Zinc, pancreatic islet function and diabetes: New insights into an old story, Nutr. Res. Rev., 26, 1, 10.1017/S0954422412000212

Shan, 2014, Interactions between zinc transporter-8 gene (SLC30A8) and plasma zinc concentrations for impaired glucose regulation and type 2 diabetes, Diabetes, 63, 1796, 10.2337/db13-0606

Marcheva, 2010, Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes, Nature, 466, 627, 10.1038/nature09253

Zheng, 2013, Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits, PLoS One, 8, e77442, 10.1371/journal.pone.0077442

Babu, 2013, Recent advances in understanding the anti-diabetic actions of dietary flavonoids, J. Nutr. Biochem., 11, 1777, 10.1016/j.jnutbio.2013.06.003

Wedick, 2012, Dietary flavonoid intakes and risk of type 2 diabetes in US men and women, Am. J. Clin. Nutr., 95, 925, 10.3945/ajcn.111.028894

Hanhineva, 2010, Impact of dietary polyphenols on carbohydrate metabolism, Int. J. Mol. Sci., 11, 1365, 10.3390/ijms11041365

Cai, 2009, Epigallocatechingallate (EGCG) and rutin suppress the glucotoxicity through activating IRS2 and AMPK signaling in rat pancreatic beta cells, J. Agric. Food Chem., 57, 9817, 10.1021/jf902618v

Zhang, 2011, Epigallocatechin-3-gallate protects pro-inflammatory cytokine induced injuries in insulin-producing cells through the mitochondrial pathway, Eur. J. Pharmacol., 670, 311, 10.1016/j.ejphar.2011.08.033

Ortsater, 2012, Diet supplementation with green tea extract epigallocatechingallate prevents progression to glucose intolerance in db/db mice, Nutr. Metab., 9, 11, 10.1186/1743-7075-9-11

Jung, 2006, Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice, Int. J. Biochem. Cell Biol., 38, 1134, 10.1016/j.biocel.2005.12.002

Sharma, 2011, Up-regulation of PPARgamma, heat shock protein-27 and -72 by naringin attenuates insulin resistance, beta-cell dysfunction, hepatic steatosis and kidney damage in a rat model of type 2 diabetes, Br. J. Nutr., 106, 1713, 10.1017/S000711451100225X

Takikawa, 2010, Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice, J. Nutr., 140, 527, 10.3945/jn.109.118216

Tsuda, 2003, Dietary cyanidin 3-O-beta-d-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice, J. Nutr., 133, 2125, 10.1093/jn/133.7.2125

Kobori, 2009, Dietary quercetin alleviates diabetic symptoms and reduces streptozotocin-induced disturbance of hepatic gene expression in mice, Mol. Nutr. Food Res., 53, 859, 10.1002/mnfr.200800310

Kim, 2007, Flavonoids protect against cytokine-induced pancreatic beta-cell damage through suppression of nuclear factor kappa B activation, Pancreas, 35, e1, 10.1097/mpa.0b013e31811ed0d2

Fu, 2010, Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice, Endocrinology, 151, 3026, 10.1210/en.2009-1294

Castellano, 2013, Biochemical basis of the antidiabetic activity of oleanolic acid and related pentacyclic triterpenes, Diabetes, 62, 1791, 10.2337/db12-1215

Zhao, 2012, Sustained antidiabetic effects of a berberine-containing Chinese herbal medicine through regulation of hepatic gene expression, Diabetes, 61, 933, 10.2337/db11-1164

Chatuphonprasert, W., Lao-Ong, T., and Jarukamjorn, K. (2013). Improvement of superoxide dismutase and catalase in streprozotocin-nicotinamide-induced type 2 diabetes in mice by berberine and glibenclamide. Pharm. Biol., in press.

Gysemans, 2005, 1,25-Dihydroxyvitamin D3 modulates expression of chemokines and cytokines in pancreatic islets: Implications for prevention of diabetes in nonobese diabetic mice, Endocrinology, 146, 1956, 10.1210/en.2004-1322

Rondas, 2014, Discovery of molecular pathways mediating 1,25-dihydroxyvitamin D3 protection against cytokine-induced inflammation and damage of human and male mouse islets of Langerhans, Endocrinology, 155, 736, 10.1210/en.2013-1409

Larrieta, 2013, Effects of biotin supplementation in the diet on insulin secretion, islet gene expression, glucose homeostasis and beta-cell proportion, J. Nutr. Biochem., 24, 169, 10.1016/j.jnutbio.2012.03.020

Cobianchi, 2008, Riboflavin inhibits IL-6 expression and p38 activation in islet cells, Cell Transplant., 17, 559, 10.3727/096368908785096060

Ye, 2006, MafA expression and insulin promoter activity are induced by nicotinamide and related compounds in INS-1 pancreatic beta-cells, Diabetes, 55, 742, 10.2337/diabetes.55.03.06.db05-0653

Xu, 2001, Metabolic regulation by leucine of translation initiation through the mTOR signaling pathway by pancreatic beta-cells, Diabetes, 50, 353, 10.2337/diabetes.50.2.353

Carneiro, 2009, Taurine supplementation modulates glucose homeostasis and islet function, J. Nutr. Biochem., 20, 503, 10.1016/j.jnutbio.2008.05.008

Corless, 2006, Glutamine regulates expression of key transcription factor, signal transduction, metabolic gene, and protein expression in a clonal pancreatic beta-cell line, J. Endocrinol., 190, 719, 10.1677/joe.1.06892

Meda, 1999, Glucose-induced preproinsulin gene expression is inhibited by the free fatty acid palmitate, Endocrinology, 140, 4005, 10.1210/endo.140.9.6953

Hagman, 2005, Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans, J. Biol. Chem., 16, 32413, 10.1074/jbc.M506000200

Qiu, 2005, Differentially expressed proteins in the pancreas of diet-induced diabetic mice, Mol. Cell Proteomics, 4, 1311, 10.1074/mcp.M500016-MCP200

Dreja, 2010, Diet-induced gene expression of isolated pancreatic islets from a polygenic mouse model of the metabolic syndrome, Diabetologia, 53, 309, 10.1007/s00125-009-1576-4

Kluth, 2011, Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: Role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure, Diabetologia, 54, 605, 10.1007/s00125-010-1973-8

Castro, 2014, Lipoic acid prevents fructose-induced changes in liver carbohydrate metabolism: Role of oxidative stress, Biochim. Biophys. Acta, 1840, 1145, 10.1016/j.bbagen.2013.12.005

Obici, 2002, Central administration of oleic acid inhibits glucose production and food intake, Diabetes, 51, 271, 10.2337/diabetes.51.2.271

Morgan, 2004, Hypothalamic responses to long-chain fatty acids are nutritionally regulated, J. Biol. Chem., 279, 31139, 10.1074/jbc.M400458200

Trojan, 2009, Pentacyclictriterpene distribution in various plant-rich sources for a new group of multi-potent plant extracts, Molecules, 14, 2016, 10.3390/molecules14062016

Guinda, 2010, Pentacyclictriterpenoids from olive fruit and leaf, J. Agric. Food Chem., 58, 9685, 10.1021/jf102039t

Dong, 2012, Berberine in the treatment of type 2 diabetes mellitus: A systemic review and meta-analysis, Evid. Based Complement. Altern. Med., 2012, 591654, 10.1155/2012/591654

Costa, 2013, β-Carotene, α-tocopherol and ascorbic acid: Differential profile of antioxidant, inflammatory status and regulation of gene expression in human mononuclear cells of diabetic donors, Diabetes Metab. Rev. Res., 29, 636, 10.1002/dmrr.2439

Latorraca, 2011, Mechanisms of insulin secretion in malnutrition: Modulation by amino acids in rodent models, Amino Acids, 40, 1027, 10.1007/s00726-010-0716-y

Dickson, 2004, Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: A role for protein kinase B in the Akt?, Am. J. Physiol. Endocrinol. Metab., 287, E192, 10.1152/ajpendo.00031.2004

Kwon, 2004, Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets, Diabetes, 53, S225, 10.2337/diabetes.53.suppl_3.S225

Newsholme, 2005, New insights into amino acid metabolism, beta-cell function and diabetes, Clin. Sci., 108, 185, 10.1042/CS20040290

Newsholme, 2007, Amino acid metabolism, insulin secretion and diabetes, Biochem. Soc. Trans., 35, 1180, 10.1042/BST0351180

Peltonen, 2006, Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: Follow-up of the Finnish Diabetes Prevention Study, Lancet, 11, 1673

Imai, 2008, Analysis of gene expression in pancreatic islets from diet-induced obese mice, Physiol. Genomics, 12, 43, 10.1152/physiolgenomics.00050.2008

Marchetti, 2012, The pancreatic beta cells in human type 2 diabetes, Adv. Exp. Med. Biol., 771, 288, 10.1007/978-1-4614-5441-0_22

Udupa, 2013, A comparative study of effects of omega-3 fatty acids, alpha lipoic acid and vitamin E in type 2 diabetes mellitus, Ann. Med. Health Sci. Res., 3, 442, 10.4103/2141-9248.117954

Marselli, 2010, Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes, Diabetologia, 53, 1395, 10.1007/s00125-010-1707-y

Choi, 2012, Genome-wide identification of palmitate-regulated immediate early genes and target genes in pancreatic beta-cells reveals a central role of NF-κB, Mol. Biol. Rep., 39, 6781, 10.1007/s11033-012-1503-5

Kharroubi, 2004, Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: Role of nuclear factor-kappaB and endoplasmic reticulum stress, Endocrinology, 145, 5087, 10.1210/en.2004-0478

Konstantinidou, 2009, Time course of changes in the expression of insulin sensitivity-related genes after an acute load of virgin olive oil, OMICS, 13, 431, 10.1089/omi.2008.0085

Kallio, 2007, Dietary carbohydrate modification induces alterations in gene expression in abdominal subcutaneous adipose tissue in persons with the metabolic syndrome: The FUNGENUT Study, Am. J. Clin. Nutr., 85, 1417, 10.1093/ajcn/85.5.1417

Crujeiras, 2008, Differential expression of oxidative stress and inflammation related genes in peripheral blood mononuclear cells in response to a low-calorie diet: A nutrigenomics study, OMICS, 12, 251, 10.1089/omi.2008.0001

Okamoto, 2004, Transgenic rescue of insulin receptor-deficient mice, J. Clin. Investig., 114, 214, 10.1172/JCI200421645

Bruning, 2000, Role of brain insulin receptor in control of body weight and reproduction, Science, 289, 2122, 10.1126/science.289.5487.2122

Duca, F.A., and Yue, J.T. (2014). Fatty acid sensing in the gut and the hypothalamus: In vivo and in vitro perspectives. Mol. Cell Endocrinol., in press.

Fick, 2010, Nutrient sensing and insulin signaling in neuropeptide-expressing immortalized, hypothalamic neurons, Cell Cycle, 16, 3186

Bird, 2007, Perceptions of epigenetics, Nature, 447, 396, 10.1038/nature05913

Ambors, 2004, The function of animals micro RNAs, Nature, 431, 350, 10.1038/nature02871

Kim, 2008, MicroRNA-directed transcriptional gene silence in mammalian cells, Proc. Natl. Acad. Sci. USA, 105, 16230, 10.1073/pnas.0808830105

2013, The emerging role of micro RNAs in the regulation of gene expression by nutrients, J. Nutrigenet. Nutrigenomics, 6, 16

Roseboom, 2006, The Dutch famine and its long-term consequences for adult health, Early Hum. Dev., 82, 485, 10.1016/j.earlhumdev.2006.07.001

Painter, 2006, Glucose tolerance at age 58 and the decline of glucose tolerance in comparison with age 50 in people prenatally exposed to the Dutch famine, Diabetologia, 49, 637, 10.1007/s00125-005-0136-9

Ng, 2010, Chronic high-fat diet in fathers programs beta-cell dysfunction in female rat offspring, Nature, 467, 963, 10.1038/nature09491

Inoue, 2009, Effect of intrauterine undernutrition during late gestation on pancreatic beta cell mass, BioMed. Res., 30, 325, 10.2220/biomedres.30.325

Volkmar, 2012, DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients, EMBO J., 21, 1405, 10.1038/emboj.2011.503

Taft, 2011, Micro RNAs in β cell biology, insulin resistance, diabetes and its complications, Diabetes, 60, 1825, 10.2337/db11-0171

Frost, 2011, Control of glucose homeostasis and insulin sensitivity by the Let-7 family of micro RNAs, Proc. Natl. Acad. Sci. USA, 108, 21075, 10.1073/pnas.1118922109

2013, miRNAS, polyphenols and chronic disease, Mol. Nutr. Food Res., 57, 58, 10.1002/mnfr.201200454

Palmer, J.D., Soule, B.P., Simone, B.A., Zaorsky, N.G., Jin, L., and Simone, N.L. (2014). Micro RNA expression altered by diet: Can food be medicinal?. Ageing Res. Rev.