Nucleoside syntheses, XXII1)Nucleoside synthesis with trimethylsilyl triflate and perchlorate as catalysts
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For the use fo SnCl4for the synthesis of purine nucleosides compare.
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H.VorbrüggenandB.Bennua unpublishend. The composition of such a mixture varies. A Short reaction time and low tempreature during preparation of the O‐methyl‐2‐deoxyribose favors the kinetically controlled turanoside (28) whereas longer reaction times or failure to remove the last traces of acides after acylation withtuluoylchloride/pyridine leads gradually to increasing amounts of the undesired pyranosides 46.
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The discrepancies in the melting points should not be taken too seriously since many nucleosides occur in several crystalline modifications. Compare for exaple the melting points of the benzoylatedN‐1‐ andN‐3‐ribosides of 6‐methyluracil23and24for which we eventually obtained higher meltin crystals Another example is lumazine riboside34bwhich also occurred in two crystalline modifications.