Nuclear Activity of MLA Immune Receptors Links Isolate-Specific and Basal Disease-Resistance Responses

American Association for the Advancement of Science (AAAS) - Tập 315 Số 5815 - Trang 1098-1103 - 2007
Qian‐Hua Shen1,2,3, Yusuke Saijo1,2,3, Stefan Mauch1,2,3, Christoph Biskup1,2,3, Stéphane Bieri1,2,3, Beat Keller1,2,3, Hikaru Seki1,2,3, Bekir Ülker1,2,3, Imre E. Somssich1,2,3, Paul Schulze‐Lefert1,2,3
1Department of Plant Microbe Interactions, Max-Planck-Institut für Züchtungsforschung, Carl-von-Linné-Weg 10, D-50829 Köln, Germany.
2Institute of Physiology II, Friedrich-Schiller-University of Jena, Teichgraben 8, D-07740 Jena, Germany.
3Institute of Plant Biology, University of Zürich, Zollikerstrasse 107, 8008 Zürich, Switzerland.

Tóm tắt

Plant immune responses are triggered by pattern recognition receptors that detect conserved pathogen-associated molecular patterns (PAMPs) or by resistance (R) proteins recognizing isolate-specific pathogen effectors. We show that in barley, intracellular mildew A (MLA) R proteins function in the nucleus to confer resistance against the powdery mildew fungus. Recognition of the fungal avirulence A10 effector by MLA10 induces nuclear associations between receptor and WRKY transcription factors. The identified WRKY proteins act as repressors of PAMP-triggered basal defense. MLA appears to interfere with the WRKY repressor function, thereby de-repressing PAMP-triggered basal defense. Our findings reveal a mechanism by which these polymorphic immune receptors integrate distinct pathogen signals.

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Materials and methods are available as supporting material on Science Online.

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We thank C. Ridout and C. Jansson for providing various plasmids; Z. Chen (Purdue University) for providing Arabidopsis wrky single and triple mutants; and E. Schmelzer E. Logemann A. Reinstaedler M. Hallstein and H. Häweker for technical support. This work was supported by funds from the Max Planck Society a Deutsche Forschungsgemeinschaft grant (SFB670) to Q.-H. S. and a European Union–BIOEXPLOIT grant to Y.S.

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American Association for the Advancement of Science (AAAS)

Tập 315 Số 5815

1098-1103

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