Novel plasmid-mediated colistin resistance mcr-4 gene in Salmonella and Escherichia coli, Italy 2013, Spain and Belgium, 2015 to 2016

Eurosurveillance - Tập 22 Số 31 - 2017
Alessandra Carattoli1, Laura Villa1, Claudia Feudi1,2, Ludovica Curcio3, Serenella Orsini3, Andrea Luppi4, Giovanni Pezzotti3, Chiara Francesca Magistrali3
1Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy
2Institute of Microbiology and Epizootics, Centre for Infection Medicine, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany
3Istituto Zooprofilattico Sperimentale dell’Umbria e delle Marche, Perugia, Italy
4Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna, Reggio Emilia, Italy

Tóm tắt

A novel mcr colistin resistance gene was identified in a strain of Salmonella enterica, monophasic variant of serovar Typhimurium (4,5,12:i:- ), isolated from a pig at slaughter in Italy in 2013, and in Escherichia coli strains collected during routine diagnostic of post-weaning diarrhoea in pigs from Spain and Belgium in 2015 and 2016. Immediate implementation of mcr-screening including this novel gene variant is required for Salmonella and E. coli from humans and food-producing animals in Europe.

Từ khóa


Tài liệu tham khảo

Rhouma, 2016, Resistance to colistin: what is the fate for this antibiotic in pig production?, Int J Antimicrob Agents, 48, 119, 10.1016/j.ijantimicag.2016.04.008

Pesciaroli, 2017, Association between pigs with high caecal Salmonella loads and carcass contamination., Int J Food Microbiol, 242, 82, 10.1016/j.ijfoodmicro.2016.11.021

European Committee on Antimicrobial Susceptibility Testing (EUCAST). Clinical Breakpoints. Växjö: EUCAST. Jun 2017. Available from: http://eucast.org/clinical_breakpoints

Zankari, 2012, Identification of acquired antimicrobial resistance genes., J Antimicrob Chemother, 67, 2640, 10.1093/jac/dks261

Carattoli, 2014, In silico detection and typing of plasmids using PlasmidFinder and plasmid multilocus sequence typing., Antimicrob Agents Chemother, 58, 3895, 10.1128/AAC.02412-14

Liu, 2016, Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study., Lancet Infect Dis, 16, 161, 10.1016/S1473-3099(15)00424-7

Xavier, 2016, Identification of a novel plasmid-mediated colistin-resistance gene, mcr-2, in Escherichia coli, Belgium, June 2016., Euro Surveill, 21, 30280, 10.2807/1560-7917.ES.2016.21.27.30280

Poirel, 2017, Polymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance Mechanisms Encoded by Plasmids or Chromosomes., Clin Microbiol Rev, 30, 557, 10.1128/CMR.00064-16

Yin, 2017, Novel Plasmid-Mediated Colistin Resistance Gene mcr-3 in Escherichia coli., MBio, 8, e00543-17, 10.1128/mBio.00543-17

Kearse, 2012, Geneious Basic: an integrated and extendable desktop software platform for the organization and analysis of sequence data., Bioinformatics, 28, 1647, 10.1093/bioinformatics/bts199

Thông tin
Thông tin xuất bản

Eurosurveillance

Tập 22 Số 31

Thông tin tác giả