Novel hyaluronic acid–methotrexate conjugate suppresses joint inflammation in the rat knee: efficacy and safety evaluation in two rat arthritis models

Tatsuya Tamura1, Y. Higuchi1, Hidetomo Kitamura1, Naoaki Murao1, Ryoichi Saitoh1, Takao Morikawa2, Haruhiko Sato1
1Research Division, Chugai Pharmaceutical Co. Ltd, 1–135 Komakado, Gotemba, Shizuoka 412-8513, Japan
2New Business Planning Department, Denka Co., Ltd., 2-1-1 Nihonbashi-Muromachi, Chuo-ku, Tokyo, 103-8338, Japan

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