Tín hiệu Notch là một yếu tố điều tiết quan trọng trong phản ứng của tế bào T CD4+ đồng loại dẫn đến bệnh ghép chống chủ

Ferrara, 2009, Graft-versus-host disease., Lancet, 373, 1550, 10.1016/S0140-6736(09)60237-3 Socie, 2009, Acute graft-versus-host disease: from the bench to the bedside., Blood, 114, 4327, 10.1182/blood-2009-06-204669 Welniak, 2007, Immunobiology of allogeneic hematopoietic stem cell transplantation., Annu Rev Immunol, 25, 139, 10.1146/annurev.immunol.25.022106.141606 Zeiser, 2006, Acute graft-versus-host disease-challenge for a broader application of allogeneic hematopoietic cell transplantation., Curr Stem Cell Res Ther, 1, 203, 10.2174/157488806776956896 Wu, 2006, Induction of tumor immunity following allogeneic stem cell transplantation., Adv Immunol, 90, 133, 10.1016/S0065-2776(06)90004-2 Das, 2009, Interleukin-23 secretion by donor antigen-presenting cells is critical for organ-specific pathology in graft-versus-host disease., Blood, 113, 2352, 10.1182/blood-2008-08-175448 Yi, 2009, Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease., Blood, 114, 3101, 10.1182/blood-2009-05-219402 Murphy, 1998, Differential effects of the absence of interferon-gamma and IL-4 in acute graft-versus-host disease after allogeneic bone marrow transplantation in mice., J Clin Invest, 102, 1742, 10.1172/JCI3906 Yang, 1998, Donor-derived interferon gamma is required for inhibition of acute graft-versus-host disease by interleukin 12., J Clin Invest, 102, 2126, 10.1172/JCI4992 Kappel, 2009, IL-17 contributes to CD4-mediated graft-versus-host disease., Blood, 113, 945, 10.1182/blood-2008-08-172155 Schmaltz, 2001, Differential use of Fas ligand and perforin cytotoxic pathways by donor T cells in graft-versus-host disease and graft-versus-leukemia effect., Blood, 97, 2886, 10.1182/blood.V97.9.2886 Graubert, 1997, Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation., J Clin Invest, 100, 904, 10.1172/JCI119606 Kopan, 2009, The canonical Notch signaling pathway: unfolding the activation mechanism., Cell, 137, 216, 10.1016/j.cell.2009.03.045 Maillard, 2004, Mastermind critically regulates Notch-mediated lymphoid cell fate decisions., Blood, 104, 1696, 10.1182/blood-2004-02-0514 Osborne, 2007, Notch signalling during peripheral T-cell activation and differentiation., Nat Rev Immunol, 7, 64, 10.1038/nri1998 Amsen, 2009, The different faces of Notch in T-helper-cell differentiation., Nat Rev Immunol, 9, 116, 10.1038/nri2488 Sandy, 2009, Notch signaling in the hematopoietic system., Expert Opin Biol Ther, 9, 1383, 10.1517/14712590903260777 Radtke, 2010, Notch signaling in the immune system., Immunity, 32, 14, 10.1016/j.immuni.2010.01.004 Amsen, 2004, Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells., Cell, 117, 515, 10.1016/S0092-8674(04)00451-9 Tu, 2005, Notch signaling is an important regulator of type 2 immunity., J Exp Med, 202, 1037, 10.1084/jem.20050923 Tanigaki, 2004, Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling., Immunity, 20, 611, 10.1016/S1074-7613(04)00109-8 Amsen, 2007, Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch., Immunity, 27, 89, 10.1016/j.immuni.2007.05.021 Yvon, 2003, Over expression of the Notch ligand, Jagged-1 induces alloantigen-specific human regulatory T cells., Blood, 102, 3815, 10.1182/blood-2002-12-3826 Mukherjee, 2009, Regulation of T cell activation by Notch ligand, DLL4, promotes IL-17 production and Rorc activation., J Immunol, 182, 7381, 10.4049/jimmunol.0804322 Minter, 2005, Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21., Nat Immunol, 6, 680, 10.1038/ni1209x Maekawa, 2008, Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity., Nat Immunol, 9, 1140, 10.1038/ni.1649 Cho, 2009, Notch regulates cytolytic effector function in CD8+ T cells., J Immunol, 182, 3380, 10.4049/jimmunol.0802598 Maekawa, 2003, delta1-Notch3 interactions bias the functional differentiation of activated CD4+ T cells., Immunity, 19, 549, 10.1016/S1074-7613(03)00270-X Maillard, 2006, The requirement for Notch signaling at the beta-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor., J Exp Med, 203, 2239, 10.1084/jem.20061020 Zakrzewski, 2006, Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantation., Nat Med, 12, 1039, 10.1038/nm1463 Zhang, 2002, Preterminal host dendritic cells in irradiated mice prime CD8+ T cell-mediated acute graft-versus-host disease., J Clin Invest, 109, 1335, 10.1172/JCI0214989 Cooke, 1996, An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin., Blood, 88, 3230, 10.1182/blood.V88.8.3230.bloodjournal8883230 Shulman, 1988, A coded histologic study of hepatic graft-versus-host disease after human bone marrow transplantation., Hepatology, 8, 463, 10.1002/hep.1840080305 Anderson, 2008, Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells., Blood, 111, 5242, 10.1182/blood-2007-09-107953 Zhang, 2004, Dendritic cell-activated CD44hiCD8+ T cells are defective in mediating acute graft-versus-host disease but retain graft-versus-leukemia activity., Blood, 103, 3970, 10.1182/blood-2003-09-3135 Lefrancois, 2001, Isolation of mouse small intestinal intraepithelial lymphocytes, Peyer's patch, and lamina propria cells., Curr Protoc Immunol, 10.1002/0471142735.im0319s17 Jedema, 2004, New CFSE-based assay to determine susceptibility to lysis by cytotoxic T cells of leukemic precursor cells within a heterogeneous target cell population., Blood, 103, 2677, 10.1182/blood-2003-06-2070 Suchin, 2001, Quantifying the frequency of alloreactive T cells in vivo: new answers to an old question., J Immunol, 166, 973, 10.4049/jimmunol.166.2.973 Benedito, 2009, The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis., Cell, 137, 1124, 10.1016/j.cell.2009.03.025 Ostroukhova, 2006, Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-beta., J Clin Invest, 116, 996, 10.1172/JCI26490 Asano, 2008, Notch1 signaling and regulatory T cell function., J Immunol, 180, 2796, 10.4049/jimmunol.180.5.2796 Adler, 2003, Notch signaling augments T cell responsiveness by enhancing CD25 expression., J Immunol, 171, 2896, 10.4049/jimmunol.171.6.2896 Li, 2001, IL-15 and IL-2: a matter of life and death for T cells in vivo., Nat Med, 7, 114, 10.1038/83253 van den Brink, 2002, Cytolytic pathways in haematopoietic stem-cell transplantation., Nat Rev Immunol, 2, 273, 10.1038/nri775 Nishimura, 2008, In vivo trafficking and survival of cytokine-induced killer cells resulting in minimal GVHD with retention of antitumor activity., Blood, 112, 2563, 10.1182/blood-2007-06-092817 Zheng, 2009, Central memory CD8+ T cells induce graft-versus-host disease and mediate graft-versus-leukemia., J Immunol, 182, 5938, 10.4049/jimmunol.0802212 Hari, 2004, Temporal discordance between graft-versus-leukemia and graft-versus-host responses: a strategy for the separation of graft-versus-leukemia/graft-versus-host reactivity?, Biol Blood Marrow Transplant, 10, 743, 10.1016/j.bbmt.2004.07.006 Real, 2009, gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia., Nat Med, 15, 50, 10.1038/nm.1900 Wu, 2010, Therapeutic antibody targeting of individual Notch receptors., Nature, 464, 1052, 10.1038/nature08878 Cullion, 2009, Targeting the Notch1 and mTOR pathways in a mouse T-ALL model., Blood, 113, 6172, 10.1182/blood-2008-02-136762