Notch Signaling: Cell Fate Control and Signal Integration in Development

American Association for the Advancement of Science (AAAS) - Tập 284 Số 5415 - Trang 770-776 - 1999
Spyros Artavanis‐Tsakonas1, Matthew D. Rand1, Robert J. Lake1
1Massachusetts General Hospital Cancer Center, Department of Cell Biology, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA.

Tóm tắt

Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development. Signals exchanged between neighboring cells through the Notch receptor can amplify and consolidate molecular differences, which eventually dictate cell fates. Thus, Notch signals control how cells respond to intrinsic or extrinsic developmental cues that are necessary to unfold specific developmental programs. Notch activity affects the implementation of differentiation, proliferation, and apoptotic programs, providing a general developmental tool to influence organ formation and morphogenesis.

Từ khóa


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We thank L. Grimm K. Mishra S. Fre and P. Mourikis for critical comments. Special thanks to J. Unternaehrer who as a rotation student studied in vivo activated Notch expression. S.A.T. is supported by NIH grant NS26084 and the Massachusetts General Hospital.