Leow C. C., Curr. Top. Microbiol. Immunol. 228, 273 (1998).
10.1146/annurev.cellbio.13.1.333
Bray S., Semin. Cell. Dev. Biol. 9, 591 (1998);
Weinmaster G., Curr. Opin. Genet. Dev. 8, 436 (1998).
Muskavitch M. A., Dev. Biol. 166, 415 (1994).
Moohr O. L., Genetics 4, 252 (1919).
Poulson D. F., Proc. Natl. Acad. Sci. U.S.A. 23, 133 (1937);
; J. Exp. Zool. 83 271 (1940).
Wright T. R., Adv. Genet. 15, 261 (1970);
Lehmann R., Jimenez F., Dietrich U., Campos-Ortega J. A., Roux's Arch. Dev. Biol. 192, 62 (1983).
Wharton K. A., Johansen K. M., Xu T., Artavanis-Tsakonas S., Cell 43, 567 (1985);
Kidd S., Kelley M. R., Young M. W., Mol. Cell. Biol. 6, 3094 (1986).
Joutel A., et al., Nature 383, 707 (1996).
Li L., et al., Nature Genet. 16, 243 (1997).
T. Oda et al. ibid. p. 235.
Gu Y., Hukriede N. A., Fleming R. J., Development 121, 855 (1995);
Zeng C., Younger-Shepherd S., Jan L. Y., Jan Y. N., Genes Dev. 12, 1086 (1998).
M. Lecourtois and F. Schweisguth ibid. p. 2598.
Oellers N., Dehio M., Knust E., Mol. Gen. Genet. 244, 465 (1994);
Heitzler P., Bourouis M., Ruel L., Carteret C., Simpson P., Development 122, 161 (1996).
Couso J. P., Martinez Arias A., Cell 79, 259 (1994);
Baker N. E., Zitron A. E., Mech. Dev. 49, 173 (1995);
Lee E. C., Baker N. E., Biochem. Biophys. Res. Commun. 225, 720 (1996);
Martinez Arias A., Int. J. Dev. Biol. 42, 325 (1998).
Hing H. K., Sun X., Artavanis-Tsakonas S., Mech. Dev. 47, 261 (1994).
Blaumueller C. M., Qi H., Zagouras P., Artavanis-Tsakonas S., Cell 90, 281 (1997).
Hardy J., Israel A., Nature 398, 466 (1999);
; M. S. Wolfe et al. ibid. p. 513; B. DeStrooper et al. ibid. p. 518; Y. Ye N. Lukinova M. E. Fortini ibid. p. 525.
G. Struhl and I. Greenwald ibid. p. 522.
Lieber T., Kidd S., Alcamo E., Corbin V., Young M. W., Genes Dev. 7, 1949 (1993);
Rebay I., Fehon R. G., Artavanis-Tsakonas S., Cell 74, 319 (1993).
10.1016/0092-8674(93)90424-O
Matsuno K., Go M. J., Sun X., Eastman D. S., Artavanis-Tsakonas S., Development 124, 4265 (1997).
Hubbard E. J. A., Dong Q., Greenwald I., Science 273, 112 (1996).
Diederich R. J., Matsuno K., Hing H., Artavanis-Tsakonas S., Development 120, 473 (1994).
Matsuno K., Diederich R. J., Go M. J., Blaumueller C. M., Artavanis-Tsakonas S., ibid. 121, 2633 (1995).
Tamura K., et al., Curr. Biol. 5, 1416 (1995).
Uemura T., Shepherd S., Ackerman L., Jan L. Y., Jan Y. N., Cell 58, 349 (1989);
Jan Y. N., Jan L. Y., Neuron 14, 1 (1995);
Spana E. P., Doe C. Q., ibid. 17, 21 (1996).
10.1016/S0896-6273(00)81007-7
Guan E., et al., J. Exp. Med. 183, 2025 (1996).
Jehn B. M., Bielke W., Pear W. S., Osborne B. A., J. Immunol. 162, 635 (1999).
Shawber C., et al., Development 122, 3765 (1996);
Wang S., Younger-Shepherd S., Jan L. Y., Jan Y. N., ibid. 124, 4435 (1997).
Brou C., et al., Genes Dev. 8, 2491 (1994).
10.1016/0092-8674(91)90263-X
Fehon R. G., Johansen K., Artavanis-Tsakonas S., J. Cell Biol. 113, 657 (1991).
Jacobsen T., Brennan K., Martinez Arias A., Muskavitch M., Development 125, 4531 (1998).
Fehon R., et al., Cell 61, 523 (1990).
10.1126/science.283.5398.91
Klueg K. M., Parody T. R., Muskavitch M. A., Mol. Biol. Cell 9, 1709 (1998).
10.1126/science.273.5279.1227
Pan D., Rubin G. M., Cell 90, 271 (1997);
Wen C., Metzstein M. M., Greenwald I., Development 124, 4759 (1997).
Sotillos S., Roch F., Campuzano S., Development 124, 4769 (1997).
X. Sun and S. Artavanis-Tsakonas ibid. p. 3439.
Fitzgerald K., Greenwald I., ibid. 121, 4275 (1995);
10.1182/blood.V91.11.4084
Blobel C. P., Cell 90, 589 (1997).
Artavanis-Tsakonas S., Nature Genet. 16, 212 (1997).
T. Xu thesis Yale University (1990);
Artavanis-Tsakonas S., Delidakis C., Fehon R. G., Annu. Rev. Cell Biol. 7, 427 (1991);
Stifani S., Blaumueller C. M., Redhead N. J., Hill R. E., Artavanis-Tsakonas S., Nature Genet. 2, 119 (1992);
; I. Rebay thesis Yale University (1993);
Kopan R., Nye J. S., Weintraub H., Development 120, 2385 (1994);
; J. S. Nye R. Kopan R. Axel ibid. p. 2421.
10.1016/0925-4773(95)00425-4
10.1016/S0960-9822(98)70300-8
10.1016/S0092-8674(00)81193-9
Pear W. S., et al., J. Exp. Med. 183, 2283 (1996).
Fortini M. E., Artavanis-Tsakonas S., Cell 79, 273 (1994);
Kidd S., Lieber T., Young M. W., Genes Dev. 12, 3728 (1998).
Gho M., Lecourtois M., Geraud G., Posakony J. W., Schweisguth F., Development 122, 1673 (1996).
Spana E. P., Kopczynski C., Goodman C. S., Doe C. Q., ibid. 121, 3489 (1995).
Frise E., Knoblich J. A., Younger-Shepherd S., Jan L. Y., Jan Y. N., Proc. Natl. Acad. Sci. U.S.A. 93, 11925 (1996);
Guo M., Jan L. Y., Jan Y. N., Neuron 17, 27 (1996).
Fanto M., Mlodzik M., Nature 397, 523 (1999);
; M. T. Cooper and S. J. Bray ibid. p. 526.
Seydoux G., Greenwald I., Cell 57, 1237 (1989).
Huppert S. S., Jacobsen T. L., Muskavitch M. A., Development 124, 3283 (1997).
Paroush Z., et al., Cell 79, 805 (1994);
Fisher A. L., Ohsako S., Caudy M., Mol. Cell. Biol. 16, 2670 (1996);
Baratz A., Stifani S., J. Biol. Chem. 272, 26604 (1997).
Kunisch M., Haenlin M., Campos-Ortega J. A., Proc. Natl. Acad. Sci. U.S.A. 91, 10139 (1994).
Seugnet L., Simpson P., Haenlin M., Development 124, 2015 (1997).
Verheyen E. M., PurCell K. J., Fortini M. E., Artavanis-Tsakonas S., Genetics 144, 1127 (1996).
Hartenstein A. Y., Rugendorff A., Tepass U., Hartenstein V., Development 116, 1203 (1992).
S. Kurata M. Go S. Artavanis-Tsakonas W. Gehring unpublished data.
Go M. J., Eastman D. S., Artavanis-Tsakonas S., Development 125, 2031 (1998).
Cagan R., Ready D., Genes Dev. 3, 1099 (1989).
Dominguez M., de Celis J. F., Nature 396, 276 (1998).
Batterham P., Davies A. G., Game A. Y., McKenzie J. A., Bioassays 18, 841 (1996);
Davies A. G., et al., Genetics 143, 1321 (1996);
Chen C. W., Jung H. S., Jiang T. X., Chuong C. M., Dev. Biol. 188, 181 (1997);
Chen Z., Newsome T., McKenzie J. A., Batterham P., Insect Biochem. Mol. Biol. 28, 601 (1998).
P. Batterham personal communication.
Diaz-Benjumea F. J., Cohen S. M., Development 121, 4215 (1995).
10.1016/0092-8674(95)90476-X
Rulifson E. J., Blair S. S., Development 121, 2813 (1995);
Doherty D., Feger G., Younger-Shepherd S., Jan L. Y., Jan Y. N., Genes Dev. 10, 421 (1996);
Axelrod J. D., Matsuno K., Artavanis-Tsakonas S., Perrimon N., Science 271, 1826 (1996).
10.1126/science.281.5375.409
Deftos M. L., He Y. W., Ojala E. W., Bevan M. J., Immunity 9, 777 (1998).
Shelly L., Fuchs C., Miele L., J. Cell. Biochem. 73, 164 (1999).
Johnston L. A., Edgar B. A., Nature 394, 82 (1998).
de Celis J. F., Tyler D. M., de Celis J., Bray S. J., Development 125, 4617 (1998).
Berry L. W., Westlund B., Schedl T., ibid. 124, 925 (1997).
J. Unternaehrer and S. Artavanis-Tsakonas unpublished data. The generation of transgenic flies expressing N act a membrane tethered constitutively activated form of Notch and N nuc a nuclear activated form of Notch has been described in (57).
We thank L. Grimm K. Mishra S. Fre and P. Mourikis for critical comments. Special thanks to J. Unternaehrer who as a rotation student studied in vivo activated Notch expression. S.A.T. is supported by NIH grant NS26084 and the Massachusetts General Hospital.