Noradrenaline uptake inhibition increases melatonin secretion, a measure of noradrenergic neurotransmission, in depressed patients

Psychological Medicine - Tập 22 Số 2 - Trang 309-315 - 1992
Eleni Palazidou1,2, A. Papadopoulos1,2, Helen Ratcliff1,2, Sheila Dawling1,2, Stuart Checkley1,2
1Department of Psychiatry, Institute of Psychiatry
2Poisons Unit, New Cross Hospital, London

Tóm tắt

SYNOPSISEight patients with endogenous depression who had received no antidepressant treatment for the previous year were treated with the noradrenaline (NA) uptake inhibitor, desipramine (DMI). Pre-treatment plasma melatonin concentrations were normal. After one day of DMI treatment plasma melatonin concentrations were increased but the response was impaired compared to normal subjects. The acute effect of DMI on plasma melatonin persisted after six weeks of treatment. These findings question the hypothesis that beta adrenoceptors are supersensitive in depression and that antidepressant drugs act by down-regulating these receptors.

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