Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection

Maximilian Muenchhoff1,2,3,4,5, Emily Adland1,5, Owen Karimanzira6, Carol Crowther6, Matthew Pace7,8,9, Anna Csala1,5, Ellen M. Leitman1,5, Angeline Moonsamy1,5, Callum McGregor1,3,5, Jacob Hurst10, Andreas Groll11, Masahiko Mori1,5, Smruti Sinmyee1,5, Christina Thobakgale3, Gareth Tudor‐Williams12, Andrew J. Prendergast13, Henrik N. Kløverpris14,15, Julia Roider1,3,15,5, Alasdair Leslie15, Delane Shingadia16, Thea Brits17, Samantha Daniel17, John Frater7,8,9, Christian B. Willberg8,9, Bruce D. Walker3,18, Thumbi Ndung’u3,15,19,18, Pieter Jooste17, Penny L. Moore20,6,21, Lynn Morris20,6,21, Philip Goulder16,1,3,5
1Department of Paediatrics, Peter Medawar Building for Pathogen Research, South Parks Road, University of Oxford, Oxford OX1 3SY, U.K.
2German Center for Infection Research (DZIF), Partner Site Munich, Ger-many.
3HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal (UKZN), Durban, South Africa.
4Max von Pettenkofer-Institute, Department of Virology, Ludwig-Maximilians-University Munich, Munich, Germany.
5University of Oxford, Oxford OX1 3SY, U.K.
6Centre for HIV and STIs, National Institute for Communicable Diseases of the Na-tional Health Laboratory Service, Johannesburg, South Africa.
7Institute for Emerging Infections, Oxford Martin School, University of Oxford, Oxford, U.K.
8Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, South Parks Road, Oxford OX1 3SY, U.K.
9Oxford National Institute of Health Research, Bio-medical Research Centre, Oxford, U.K.
10Institute of Cancer Research, Old Brompton Road, Lon-don SW7 3RP, U.K.
11Department of Mathematics, Ludwig-Maximilians-University Munich, Theresienstrasse 39, 80333 Munich, Germany.
12Department of Paediatrics, Imperial College London, London, U.K.
13Blizard Institute, Queen Mary University of London, London, U.K
14Department of Immunology and Micro-biology, University of Copenhagen, Copenhagen, Denmark.
15KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH), University of Kwa-Zulu-Natal (UKZN), 4001 Durban, South Africa.
16Department of Paediatric Infectious Diseases, Great Ormond Street Hospital for Children, London, U.K.
17Paediatric De-partment, Kimberley Hospital, Northern Cape, South Africa.
18Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139-4307, USA.
19Max Planck Institute for Infection Biology, Berlin, Germany
20Center for the AIDS Programme of Research in South Africa (CAPRISA), 4001 Durban, South Africa.
21Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Tóm tắt

Pediatric HIV patients who do not rapidly develop AIDS are shown to have immunological features similar to nonhuman primates that experience nonpathogenic SIV infection.

Từ khóa


Tài liệu tham khảo

10.1086/374786

10.1086/524143

10.1001/jama.2012.6698

10.1016/B978-0-12-407707-2.00002-3

10.1038/nm0295-129

10.1182/blood-2003-09-3333

10.1016/S1074-7613(03)00060-8

10.1128/CMR.00009-06

10.1126/science.1217550

10.1038/nri.2016.19

10.1097/00042560-199704150-00008

10.1016/S0140-6736(04)17140-7

10.1097/QAD.0b013e3281a3bec2

10.1016/j.jaci.2004.11.054

10.1371/journal.ppat.1004345

10.1172/JCI45235

10.1016/j.jaci.2010.09.038

10.1086/522013

10.1086/526786

10.1371/journal.ppat.1004954

10.1016/j.immuni.2012.09.005

10.1182/blood-2005-12-4897

10.1038/nm.2395

10.1016/j.jaci.2003.07.003

Lugada E. S., Mermin J., Kaharuza F., Ulvestad E., Were W., Langeland N., Asjo B., Malamba S., Downing R., Population-based hematologic and immunologic reference values for a healthy Ugandan population. Clin. Diagn. Lab. Immunol. 11, 29–34 (2004).

10.7326/0003-4819-126-12-199706150-00003

10.1038/nm1511

10.1093/infdis/jiq118

10.1093/infdis/jiu238

10.1038/nri3862

10.1198/000313002533

P. McCullagh J. A. Nelder Generalized Linear Models (Chapman & Hall ed. 2 1989).

Tibshirani R., Regression shrinkage and selection via the lasso. J. R. Stat. Soc. B Methodol. 58, 267–288 (1996).

10.18637/jss.v033.i01

Goeman J. J., L1 penalized estimation in the Cox proportional hazards model. Biom. J. 52, 70–84 (2010).

10.1111/j.1467-9868.2007.00627.x

10.1128/JVI.00295-10

10.1128/JVI.01862-12

10.1128/JVI.01221-14

10.1128/JVI.02036-08

10.1128/JVI.00198-11

10.1038/nm.3565

10.1097/COH.0000000000000057

10.1038/nm1520

10.1371/journal.ppat.1003011

10.1371/journal.ppat.1003958

10.1128/JVI.03515-13

10.1038/nm.1972

10.1038/nm.3445

10.1371/journal.ppat.1003174

10.1016/j.cell.2013.09.020

10.7554/eLife.03821

10.1371/journal.ppat.1005472

10.1038/nature03113

10.1038/nature01470

10.1086/651144

10.1038/nri3277

10.1038/nm.2233

10.1038/nm.4063

10.1146/annurev-immunol-031210-101400

10.1038/nm.2004

10.1038/nm.1970

10.1038/8400

10.1016/j.jim.2004.06.010

Montefiori D. C., Evaluating neutralizing antibodies against HIV, SIV, and SHIV in luciferase reporter gene assays. Curr. Protoc. Immunol. Chapter 12, Unit 12.11 (2005).

10.1128/JVI.78.3.1160-1168.2004