Nonmotor Symptoms and Cognitive Decline in de novo Parkinson’s Disease

Canadian Journal of Neurological Sciences - Tập 41 Số 5 - Trang 597-602 - 2014
Kyum‐Yil Kwon1, Sung Hoon Kang1, Minjik Kim1, Hye Mi Lee1, Ji Wan Jang1, Ju Yeon Kim2, Seon-Min Lee1, Seong‐Beom Koh1
11Department of Neurology and Parkinson's Disease Centre,Korea University Guro Hospital,Korea University College of Medicine,Seoul,Korea.
22Parkinson/Alzheimer Center,Department of Neurology,Asan Medical Center,University of Ulsan College of Medicine,Seoul,Korea.

Tóm tắt

AbstractBackgroundCognitive impairments are common in Parkinson’s disease (PD). Despite its clinical importance, the development of dementia is still difficult to predict. In this study, we investigated the possible associations between non-motor symptoms and the risk of developing dementia within a 2-year observation period in PD.MethodsA total of 80 patients with PD participated in this study. Nonmotor symptoms (the Nonmotor Symptoms Questionnaire), PD status (Unified Parkinson’s Disease Rating Scale), depression (Geriatric d Depression Scale or Montgomery-Asberg Depression Scale), stereopsis and severity of nonmotor symptoms (Non-motor symptoms scale) were assessed. Global cognitive function (Mini-Mental State Examination) were evaluated at baseline and 2 years later.ResultsPresence of depression, vivid dreaming, REM sleep behavior disorders, hyposmia, abnormal stereopsis, non-smoking and postural instability/ gait disturbance phenotype were associated with a significantly more rapid decline of Mini-Mental State Examination. Logistic regression analyses demonstrated that depression (odds ratio=13.895), abnormal stereopsis (odds ratio=10.729), vivid dreaming (odds ratio=4.16), REM sleep behavior disorders (odds ratio=5.353) and hyposmia (odds ratio=4.911) were significant independent predictors of dementia risk within 2 years. Postural instability/ gait disturbance phenotype and age >62 years were also independent predictors of dementia risk (odd ratio=38.333, odds ratio=10.625).ConclusionWe suggest that depression, vivid dreaming, REM sleep behavior disorders, hyposmia and abnormal stereopsis are closely associated with cognitive decline, and that presence of these nonmotor symptoms predict the subsequent development of Parkinson’s disease dementia.

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Thông tin
Thông tin xuất bản

Canadian Journal of Neurological Sciences

Tập 41 Số 5

597-602

Thông tin tác giả