Non‐coding RNAs in cancer initiation and progression and as novel biomarkers

Molecular Oncology - Tập 5 Số 6 - Trang 483-491 - 2011
S. Patrick Nana‐Sinkam1,2, Carlo M. Croce3,2
1Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, The Ohio State University, 473 West 12th Avenue, Columbus, OH 43210, USA
2James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
3Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, 410 West 10th Avenue, Columbus, OH 43210, USA

Tóm tắt

Cancer represents a complex group of heterogeneous diseases. While many cancers share fundamental biological processes (hallmarks of cancer) necessary for their development and progression, cancers also distinguish themselves by their dependence on distinct oncogenic pathways. Over the last decade, targeted therapies have been introduced to the clinic with variable success. In truth, single targeted therapies may be successful in only a subset of malignancies but insufficient to address malignancies that often rely on multiple pathways, thus evading single targeted agents. Investigators have recently identified potentially functional components of the human genome that were previously thought to have no biological function. This discovery has added to the already established complexity of gene regulation in the pathogenesis of cancer. Non‐coding RNAs represent key regulators of gene expression. Improved knowledge of their biogenesis and function may in turn lead to a better understanding of the heterogeneity of malignancies and eventually be leveraged as diagnostic, prognostic and therapeutic targets. MicroRNAs (miRNAs or miRs) for example, have the capacity for the regulation of multiple genes and thus redirection or reprogramming of biological pathways. However, several other members of the non‐coding RNA family may be of equal biological relevance. In this review, we provide a perspective on emerging concepts in the clinical application of miRNA and other non‐coding RNAs as biomarkers in cancer with an eye on the eventual integration of both miRNA and other non‐coding RNA biology into our understanding of cancer pathogenesis and treatment.

Từ khóa


Tài liệu tham khảo

10.1073/pnas.1019055108

10.1126/science.1098119

10.1073/pnas.1100048108

10.1128/MCB.10.1.28

10.1038/349038a0

10.1038/nrc1997

10.1073/pnas.242606799

10.1056/NEJMoa050995

10.1016/j.ccr.2007.07.027

10.1038/nm1111-1521a

10.1038/mt.2010.136

10.1158/0008-5472.CAN-06-3533

10.1371/journal.pone.0018108

10.1016/j.semcdb.2011.01.001

10.1038/nrg2634

10.1038/nrg1527

10.1016/j.cub.2010.08.052

10.1038/modpathol.3800937

10.1101/gr.082701.108

10.1038/nrd3179

10.1038/sj.bjc.6606076

10.1186/1476-4598-10-38

10.1158/0008-5472.CAN-11-0241

10.1016/j.molcel.2007.06.017

10.1038/nature08975

10.1016/j.ccr.2010.08.013

10.1073/pnas.0307981100

10.1634/theoncologist.2010-0103

10.4161/rna.7.5.13216

10.1371/journal.pone.0003694

Izzotti A., 2010, Dose-responsiveness and persistence of microRNA expression alterations induced by cigarette smoke in mouse lung, Mutat. Res.

10.1038/sj.onc.1206928

10.1158/0008-5472.CAN-10-4460

Kim C.W., 2002, Extracellular membrane vesicles from tumor cells promote angiogenesis via sphingomyelin, Cancer Res., 62, 6312

10.1158/0008-5472.CAN-11-1021

10.1002/hep.24504

10.1038/ng2003

10.1016/j.mrfmmm.2011.03.008

Lai M.C., 2011, Long non-coding RNA MALAT-1 overexpression predicts tumor recurrence of hepatocellular carcinoma after liver transplantation, Med. Oncol.

10.1126/science.1178178

10.1517/14712598.7.9.1363

10.1016/0092-8674(93)90529-Y

10.1007/s00281-011-0250-3

10.1373/clinchem.2011.165068

Lopez-Serra P., 2011, DNA methylation-associated silencing of tumor-suppressor microRNAs in cancer, Oncogene

10.1038/onc.2010.361

10.1038/ncb2024

10.1097/MEG.0b013e328306a3a2

10.1016/j.ccr.2010.09.007

10.1073/pnas.0804549105

10.1038/onc.2008.373

10.1038/ng.786

10.1053/j.gastro.2006.08.026

10.1016/S1470-2045(11)70044-4

10.1007/978-1-61779-289-2_13

10.1016/j.cell.2007.05.022

10.4161/cc.5.19.3340

10.1001/jama.299.4.425

10.1371/journal.pgen.1002071

10.1186/1471-2407-11-374

10.1038/ncb1800

10.1158/1078-0432.CCR-11-1712

10.1016/j.febslet.2010.10.008

10.1038/onc.2009.445

10.1038/mt.2011.48

10.1126/science.1192002

10.1038/ncb1596

10.1016/j.cell.2009.03.047

10.1101/gr.098046.109

10.1093/nar/gkq285

10.1038/nnano.2011.147

10.1093/carcin/bgp209

10.1021/mp2002076

10.1261/rna.1034808

10.1016/j.ccr.2006.01.025

10.1186/1476-4598-10-117

10.1093/carcin/bgm290

10.1245/s10434-011-1581-y

Thông tin
Thông tin xuất bản

Molecular Oncology

Tập 5 Số 6

483-491

Thông tin tác giả