Nitric oxide production, systemic inflammation and lipid metabolism in periodontitis patients: possible gender aspect

Journal of Clinical Periodontology - Tập 40 Số 10 - Trang 916-923 - 2013
Oleh Andrukhov1, Hady Haririan2, Kristina Bertl3, Wolf‐Dieter Rausch4, Hans‐Peter Bantleon5, Andreas Moritz2, Xiaohui Rausch‐Fan6,7,1,5,8,9
1Central Research Unit, Bernhard Gottlieb School of Dentistry, Medical University of Vienna, Vienna, Austria
2Division of Conservative Dentistry, Periodontology and Prophylaxis, Bernhard Gottlieb School of Dentistry, Medical University of Vienna, Vienna, Austria
3Division of Oral Surgery, Bernhard Gottlieb School of Dentistry, Medical University of Vienna, Vienna, Austria
4Department of Biomedical Sciences, Institute for Chemistry and Biochemistry, University of Veterinary Medicine, Vienna, Austria
5Division of Orthodontics, Bernhard Gottlieb School of Dentistry, Medical University of Vienna, Vienna, Austria
6Address:
7Austria
8Division of Orthodontics, Bernhard Gottlieb School of Dentistry, Sensengasse 2a, 1090 Vienna
9Xiaohui Rausch-Fan

Tóm tắt

AbstractAimNitric oxide (NO) plays a crucial role in vascular tone regulation and is involved in pathogenesis of periodontitis. In this cross‐sectional study, we investigated the serum and saliva levels of NO metabolites in periodontal disease and their relationship with serum C‐reactive protein (CRP) levels, lipids metabolism and periodontal disease severity.Material and MethodsSerum and saliva were collected from non‐smoking patients with generalized severe periodontitis (n = 89) and healthy controls (n = 56). Serum and salivary levels of NO metabolites, serum levels of high density lipoproteins (HDL), low density lipoproteins (LDL), triglycerides, cholesterol and CRP were measured. Data were analysed in whole population and in different gender groups.ResultsPeriodontitis patients exhibited significantly lower serum and saliva levels of NO metabolites and significantly higher LDL, cholesterol and CRP levels than control group. Similar findings were observed within male but not within female population. Serum NO metabolites levels exhibited significant negative correlation with CRP in whole population and in male population. Significant positive correlation of serum NO metabolite levels with HDL levels was observed in whole population.ConclusionNO production is reduced in periodontitis, especially in male population. Gender might be an important factor in assessing risk of cardiovascular disease in periodontitis.

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10.1902/jop.1993.64.5.323

10.1161/01.ATV.0000078603.90302.4A

10.1902/annals.1999.4.1.1

10.1161/01.CIR.0000131512.50667.46

10.1034/j.1600-051x.2001.028006565.x

10.1002/(SICI)1097-0347(199807)20:4<304::AID-HED4>3.0.CO;2-2

10.1097/00000441-200506000-00009

10.1016/j.ejim.2006.12.003

Bodis S., 1994, Significantly reduced salivary nitric oxide levels in smokers, Annals of Oncology, 5, 371, 10.1093/oxfordjournals.annonc.a058845

10.1111/j.1600-051X.2009.01430.x

10.1038/sj.ijir.3901209

10.1182/blood-2004-03-0880

10.1902/jop.1999.70.12.1429

10.1161/01.STR.0000136767.71518.36

10.1111/j.1600-0722.2004.00153.x

10.1038/nm0695-546

10.1093/humrep/16.7.1334

10.1902/jop.2009.097001

10.1038/288373a0

10.1016/j.lfs.2008.06.010

10.1006/bbrc.1995.2364

10.1111/j.1600-0765.1993.tb01049.x

10.1161/HYPERTENSIONAHA.107.101535

10.1177/0022034510375281

10.1034/j.1601-0825.2001.70102.x

10.1016/S0891-5849(03)00406-4

10.1038/sj.bjp.0705323

10.1159/000026342

10.1385/IR:34:3:177

10.4103/0972-124X.55842

Moncada S., 1991, Nitric oxide: physiology, pathophysiology, and pharmacology, Pharmacological Reviews, 43, 109

10.1093/clinchem/41.6.892

10.1111/j.1600-051X.2007.01133.x

10.1016/S0002-9149(97)00189-6

10.1902/jop.2010.100199

10.1111/j.1601-5037.2011.00508.x

10.1172/JCI200318921

10.1046/j.1365-2362.2001.00903.x

10.2334/josnusd.49.271

10.1006/bbrc.1995.1541

10.1016/S0008-6363(01)00388-1

10.1006/bbrc.1994.2107

10.1111/jcpe.12060

10.1902/jop.2010.100044

10.1902/jop.2010.100045

10.1073/pnas.98.1.355

10.1056/NEJMoa063186

10.1111/jcpe.12089

10.1161/hc1002.105935

10.1016/j.cca.2005.10.018

10.1136/heart.85.3.342

10.1136/bmj.309.6952.453

10.1161/01.ATV.17.11.3147

10.1016/S0009-8981(00)00340-5

10.3109/08037059409102274

10.1111/j.1743-6109.2008.01141.x

10.1111/j.1743-6109.2011.02361.x

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Journal of Clinical Periodontology

Tập 40 Số 10

916-923

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