Nitric oxide production, systemic inflammation and lipid metabolism in periodontitis patients: possible gender aspect

Journal of Clinical Periodontology - Tập 40 Số 10 - Trang 916-923 - 2013
Oleh Andrukhov1, Hady Haririan2, Kristina Bertl3, Wolf‐Dieter Rausch4, Hans‐Peter Bantleon5, Andreas Moritz2, Xiaohui Rausch‐Fan6,7,1,5,8,9
1Central Research Unit, Bernhard Gottlieb School of Dentistry, Medical University of Vienna, Vienna, Austria
2Division of Conservative Dentistry, Periodontology and Prophylaxis, Bernhard Gottlieb School of Dentistry, Medical University of Vienna, Vienna, Austria
3Division of Oral Surgery, Bernhard Gottlieb School of Dentistry, Medical University of Vienna, Vienna, Austria
4Department of Biomedical Sciences, Institute for Chemistry and Biochemistry, University of Veterinary Medicine, Vienna, Austria
5Division of Orthodontics, Bernhard Gottlieb School of Dentistry, Medical University of Vienna, Vienna, Austria
6Address:
7Austria
8Division of Orthodontics, Bernhard Gottlieb School of Dentistry, Sensengasse 2a, 1090 Vienna
9Xiaohui Rausch-Fan

Tóm tắt

AbstractAim

Nitric oxide (NO) plays a crucial role in vascular tone regulation and is involved in pathogenesis of periodontitis. In this cross‐sectional study, we investigated the serum and saliva levels of NO metabolites in periodontal disease and their relationship with serum C‐reactive protein (CRP) levels, lipids metabolism and periodontal disease severity.

Material and Methods

Serum and saliva were collected from non‐smoking patients with generalized severe periodontitis (n = 89) and healthy controls (n = 56). Serum and salivary levels of NO metabolites, serum levels of high density lipoproteins (HDL), low density lipoproteins (LDL), triglycerides, cholesterol and CRP were measured. Data were analysed in whole population and in different gender groups.

Results

Periodontitis patients exhibited significantly lower serum and saliva levels of NO metabolites and significantly higher LDL, cholesterol and CRP levels than control group. Similar findings were observed within male but not within female population. Serum NO metabolites levels exhibited significant negative correlation with CRP in whole population and in male population. Significant positive correlation of serum NO metabolite levels with HDL levels was observed in whole population.

Conclusion

NO production is reduced in periodontitis, especially in male population. Gender might be an important factor in assessing risk of cardiovascular disease in periodontitis.

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Tài liệu tham khảo

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Journal of Clinical Periodontology

Tập 40 Số 10

916-923

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