Nitric oxide and aneurysm formation in Kawasaki disease

Wiley - Tập 86 Số 5 - Trang 470-473 - 1997
Tadashi Iizuka1, Ko Oishi2, Mitsuyo Sasaki3, Y Hatanaka3, Yohsuke Minatogawa4, Shigeru Uemura2, Masato Koike2
1Kihoku Hospital, Wakayama Medical College, Japan.
2Department of Paediatrics Kawasaki Medical School, Okaxmna, Japan
3Kihoku Hospital Kawasaki Medical School, Okaxmna, Japan
4Wakayama Medical College, Wakuyama, and Department of Biochemistry Kawasaki Medical School, Okaxmna, Japan

Tóm tắt

The objective of this study is to show that nitric oxide plays a role in the development of coronary artery abnormalities in Kawasaki disease. We examined nitrite + nitrate, biopterin and neopterin in 316 urine samples of 34 patients with Kawasaki disease, those of 24 patients with other diseases, and those of 25 healthy children acting as a control group, because urinary nitrite + nitrate are reportedly useful as markers of nitric oxide generation in vivo, and pathways for neopterin‐biopterin synthesis and nitric oxide generation are tightly coupled. In our study, the children with Kawasaki disease excreted more urinary nitrite + nitrate and neopterin than did the healthy control group children and excreted abnormally high quantities more often than did the patients with other diseases. Good relationships were found between the urinary nitrite + nitrate levels and the urinary biopterin levels, and between these biopterin levels and the urinary neopterin levels. Nitric oxide is therefore thought to be generated in abnormally high quantities, and to be closely related to the pathology of Kawasaki disease and to the development of coronary artery abnormalities. The role of nitric oxide in Kawasaki disease should be further studied to elucidate the pathophysiology of the disease and to aid in the development of new treatments.

Từ khóa


Tài liệu tham khảo

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Thông tin
Thông tin xuất bản

Wiley

Tập 86 Số 5

470-473

Thông tin tác giả